A5023924786- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Blood Pressure and Hypertension Studies
- Colorectal Cancer Screening and Detection
- Tracheal and airway disorders
- Ultrasound and Hyperthermia Applications
- Cancer-related gene regulation
- Neuroendocrine Tumor Research Advances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatocellular Carcinoma Treatment and Prognosis
- Photoacoustic and Ultrasonic Imaging
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
Sun Yat-sen University
2010-2024
Sun Yat-sen University Cancer Center
2010-2024
State Key Laboratory of Oncology in South China
2010-2024
First Affiliated Hospital of Henan University
2009-2024
Key Laboratory of Guangdong Province
2024
Center for Excellence in Molecular Cell Science
2004-2021
Chinese Academy of Sciences
2004-2021
Fudan University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
First Hospital of Jilin University
2012-2019
Circulating tumor DNA methylation–based signatures are potential biomarkers for early diagnosis and prognosis of colorectal cancer.
During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Recently, we reported that zebularine [1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one] acts as an inhibitor of exhibits chemical stability minimal cytotoxicity both vitro vivo. Here show continuous application to T24 cells induces maintains p16 gene expression sustains demethylation the 5' region for over 40 days, preventing remethylation. In...
Chronic renal failure (CRF) is a major public health problem worldwide. Hydrogen sulfide (H2S) plays important roles in physiological and pathophysiological processes. However, whether H2S could protect against CRF rats remains unclear. In this study, we found that alleviated gentamicin-induced nephrotoxicity by reducing reactive oxygen species (ROS)-mediated apoptosis normal rat kidney-52E cells. We demonstrated significantly improved the kidney structure function of rats. decreased protein...
While methylcytosines serve as the fifth base encoding epigenetic information, they are also a dangerous endogenous mutagen due to their intrinsic instability. Methylcytosine undergoes spontaneous deamination, at rate much higher than cytosine, generate thymine. In mammals, two repair enzymes, thymine DNA glycosylase (TDG) and methyl-CpG binding domain 4 (MBD4), have evolved counteract mutagenic effect of methylcytosines. Both recognize G/T mismatches arising from methylcytosine deamination...
Propionylation has been identified recently as a new type of protein post-translational modification. Bacterial propionyl-CoA synthetase and human histone H4 are propionylated at specific lysine residues that have known previously to be acetylated. However, other proteins subject this modification remain identified, the modifying enzymes involved need characterized. In work, we report discovery H3 propionylation in mammalian cells. Lys(23) was detected leukemia cell line U937 by mass...
During spermiogenesis, round spermatids are converted into motile sperm in mammals. The mechanisms responsible for morphogenesis poorly understood. We have characterized a novel protein, RIM-BP3, with specialized function spermatid development mice. RIM-BP3 protein is associated the manchette, transient microtubular structure believed to be important during spermiogenesis. Targeted deletion of gene resulted male infertility owing abnormal heads, which by deformed nucleus and detached...
Chemotherapy remains the common therapeutic for patients with lung cancer. Novel, selective antitumor agents are pressingly needed. This study is first to investigate a different, however, effective drug candidate Wentilactone A (WA) its development as novel agent. In NCI-H460 and NCI-H446 cell lines, WA triggered G2/M phase arrest mitochondrial-related apoptosis, accompanying accumulation of reactive oxygen species (ROS). It also induced activation mitogen-activated protein kinase p53...
BackgroundThis study compared the performance of endoscopic ultrasonography (EUS) and multislice spiral computed tomography (MSCT) in preoperative staging gastric cancer. Methodology/Principal FindingsA total 610 patients participated this study, all whom had undergone surgical resection, confirmed cancer were evaluated with EUS MSCT. Tumor was using Tumor-Node-Metastasis (TNM) Japanese classification. The results from imaging modalities postoperative histopathological outcomes. overall...
AIM:To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in treatment patients with liver cancer. METHODS:HIFU was performed 100 cancer under general anesthesia and by a targeted ultrasound.Evaluation efficacy made on basis symptoms, function tests, AFP, MRI or CT before after treatment. RESULTS:After HIFU treatment, symptoms were relieved 86.6%(71/82) patients.The ascites disappeared 6 patients.ALT (95±44) U/L AST (114±58) reduced to normal 83.3%(30/36) 72.9%(35/48)...
Biological methylation is a fundamental enzymatic reaction for variety of substrates in multiple cellular processes. Mammalian N6amt1 was thought to be homologue bacterial N(6)-adenine DNA methyltransferases, but its substrate specificity and physiological importance remain elusive. Here, we demonstrate that functions as protein methyltransferase the translation termination factor eRF1 mammalian cells both vitro vivo. Mass spectrometry analysis indicated about 70% endogenous methylated at...
As an inflammatory disease afflicting the heart muscle, autoimmune myocarditis (AM) represents one of foremost causes failure. Accumulating evidence has implicated microRNAs (miRNAs) in process inflammation and autoimmunity. Hence, current study aimed to investigate mechanism by which miR-141-3p influences experimental AM (EAM). An EAM mouse model was established using 6-wk old male BALB/c mice, after expression STAT4 measured. Gain-of-function loss-of-function investigations were performed...
4016 Background: Challenges persist in the treatment of aEC, particularly for pts with esophageal stenosis and dysphagia, conditions that deteriorate nutrition status hinder anti-tumor therapies, leading to dismal prognosis. Building on promising activity improvement dysphagia a phase II single-arm trial, III DYNA-Esophagus03 trial assessed DVDMS, novel photosensitizer, -mediated PDT comparing TPC. Methods: Pts local recurrence or metastasis EC Stoller grade ≥2, stratified by previous lines...
The aim of this study was to evaluate our experience with the application endoscopic sonography in preoperative staging rectal cancer.Between April 2004 and May 2010, 192 patients cancer first underwent then surgery at hospital. None received neoadjuvant therapy. sonographic results were compared those postoperative pathologic staging.The accuracy overall T 86.5%, for T1, T2, T3, T4, rates 86.7%, 94.0%, 86.2%, 65.5%, respectively. ulcerated lesions significantly lower than that nonulcerated...
Abstract Zinc finger protein 154 (ZNF154) is hypermethylated at the promoter in many epithelial-derived solid tumors. However, its methylation status and function esophageal squamous carcinoma (ESCC) are poorly understood. We found that ZNF154 ESCC portends poor prognosis. In addition, functions as a tumor suppressor gene (TSG) ESCC, downregulated by hypermethylation. established targeted demethylation strategy based on CRISPR/dCas9 technology hypermethylation of repressed induction, which...
Abstract The ten-eleven translocation (Tet) family of dioxygenases convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Previous studies have shown that 5hmC-mediated epigenetic modifications play essential roles in diverse biological processes and diseases. Here, we show Tet proteins 5hmC display dynamic features during postnatal cardiac development Tet2 is the predominant dioxygenase present heart. knockout results abnormal function, progressive hypertrophy fibrosis....
This research aimed to examine the diagnostic accuracy and clinical significance of endoscopic ultrasonography (EUS) in context small rectal neuroendocrine neoplasms (NENs). A total 108 patients with subepithelial lesions (SELs) a diameter < 20 mm were included analysis. The diagnosis depth assessment EUS was compared histology findings. prevalence NENs SELs 78.7% (85/108). sensitivity detecting 98.9% (84/85), while specificity 52.2% (12/23). Overall, identifying 88.9% (96/108). overall...