A5100344420- Dialysis and Renal Disease Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Kidney Disease and Diabetes
- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Potassium and Related Disorders
- Gastric Cancer Management and Outcomes
- Bacterial Infections and Vaccines
- Gout, Hyperuricemia, Uric Acid
- Systemic Lupus Erythematosus Research
- Peptidase Inhibition and Analysis
- Acute Kidney Injury Research
- Central Venous Catheters and Hemodialysis
- Prostate Cancer Treatment and Research
- Esophageal Cancer Research and Treatment
- Heart Failure Treatment and Management
- Infectious Encephalopathies and Encephalitis
- Circular RNAs in diseases
- Healthcare professionals’ stress and burnout
- MRI in cancer diagnosis
- Renal Diseases and Glomerulopathies
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Ratio
2024
Beijing Drainage Group (China)
2024
Zhoushan Hospital
2024
Although the role of TGF-β in tumor progression has been studied extensively, its impact on drug delivery tumors remains far from understood. In this study, we examined effect blockade and efficacy conventional therapeutics nanotherapeutics orthotopic mammary carcinoma mouse models. We used both genetic (overexpression sTβRII, a soluble type II receptor) pharmacologic (1D11, neutralizing antibody) approaches to block signaling. two models (human MDA-MB-231 murine 4T1 cell lines),...
The relationship between physicians and nurses in the delivery of anesthesia care is politically financially charged, hotly debated. Against this backdrop, federal regulators have proposed dropping a Medicare requirement that nurse anesthetists be supervised by physician. Proponents note new regulations would resolve inconsistencies supervisory requirements state law, while opponents voice concerns for patient safety. This Issue Brief describes current controversy, summarizes newly published...
The prevalence of chronic kidney disease (CKD) at high altitude is not known. We conducted a population-based survey in Tibet to identify the and associated risk factors CKD subjects living altitudes > 3500 m.One thousand two hundred eighty-nine Tibetans (≥ 18 years) from four districts Lhasa city (altitude 3658 m) eight villages Dangxiong County 4200 were interviewed tested for haematuria, albuminuria estimated glomerular filtration rate (eGFR).The adjusted hypertension, albuminuria,...
Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway a metabolic route able to convert glucose into fructose. Here we show the detrimental role of endogenous fructose production by and its metabolism through fructokinase pathogenesis ischaemic acute (iAKI). Consistent elevated urinary AKI patients, mice undergoing iAKI significant activation cortex characterized levels aldose reductase, sorbitol Wild type but not knockout...
Epithelial–mesenchymal transition (EMT) is a crucial programme in cancer metastasis. Epidermal growth factor (EGF) key inducer of EMT, and Ezrin has an important role this process. However, how activated whether it mediates EGF-induced EMT tongue squamous cell carcinomas (TSCCs) through activating NF-κB remains obscure. We used two TSCC lines as model to study invasion vitro, nude mice xenografts evaluate metastasis cells. Finally, we evaluated the level pEzrin Tyr353, nuclear p65 markers...
Abstract Background Recent studies have shown that triglyceride glucose-body mass index (TyG-BMI) is associated with the risk of ischemic stroke and coronary artery disease. However, little attention has been given to association between TyG-BMI cardiovascular disease (CVD) mortality in patients undergoing peritoneal dialysis (PD). Therefore, this study aimed explore relationship CVD southern Chinese PD. Methods Incident receiving PD from January 1, 2006, December 31, 2018, baseline serum...
Abstract Decreased plasma spermine levels are associated with kidney dysfunction. However, the role of in disease remains largely unknown. Herein, it is demonstrated that oxidase (SMOX), a key enzyme governing polyamine metabolism, predominantly induced tubular epithelium human and mouse fibrotic kidneys, alongside reduction renal content mice. Moreover, SMOX expression positively correlated fibrosis function decline patients chronic disease. Importantly, supplementation exogenous or...
Proliferation and epithelial–mesenchymal transition (EMT) of lens epithelium cells (LECs) may contribute to anterior subcapsular cataract (ASC) posterior capsule opacification (PCO), which are important causes visual impairment. Histone deacetylases (HDACs)-mediated epigenetic mechanism has a central role in controlling cell cycle regulation, proliferation differentiation variety the pathogenesis some diseases. However, whether HDACs involved regulation EMT LECs remain unknown. In this...
Urgent-start peritoneal dialysis (PD) can help patients with end-stage renal diseases (ESRD) that are referred late to dialysis. However, catheter patency and related complications of urgent-start PD have not been thoroughly clarified. We investigated the clinical outcomes in a Chinese cohort. enrolled ESRD who received (starting within 14 days after insertion) our center from January 1, 2006 December 31, 2014, followed them up for 10 years. The primary outcome was failure. Secondary...
To investigate the role of calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) in colon cancer growth, migration and invasion.
ABSTRACT Aims To investigate the association of CYP2A6 genetic polymorphisms with smoking‐related phenotypes in Chinese smokers. Design Case‐only study. Setting Southern China. Participants A total 1328 Han smokers who participated a community‐based chronic disease screening project Guangzhou and Zhuhai from 2006 to 2007. Measurements All participants answered structured questionnaire about socio‐demographic status smoking behaviors informative alleles were genotyped for cytochrome P450 2A6...
The study was aimed at detecting the expression of a newly found oncogene, astrocyte elevated gene-1 (AEG-1), in renal cell carcinoma (RCC) and its correlation with histopathologic features survival patients. Real-time reverse transcription-PCR Western blot showed markedly higher AEG-1 8 cases RCC tissue compared paired normal from same patient. level also increased four lines contrast tubular epithelial human kidney cells 2 (HK-2) both mRNA protein levels. Furthermore, immunohistochemistry...
Abstract: Several studies have proved transrectal ultrasonography (TRUS) is efficient in the evaluation of patients with hematospermia, but numbers were less than 60 each previous reports. Herein, a total 270 hematospermia evaluated by TRUS to assess its efficacy etiologic diagnosis hematospermia. The age ranged from 15 75 years (x̄, 41.2 years), and duration symptoms was 1 day 8 3.4 months). Abnormalities revealed 256 (94.8%). percentages pathological conditions located seminal vesicles,...
Abstract We determined the mitogen-activated protein kinase (MAPK) gene expression profile of acquired resistance in sorafenib-sensitive hepatocellular carcinoma (HCC) cells and aimed to identify c-Jun as an important molecule mediating efficacy sorafenib. Differences MAPK signaling between untreated sorafenib-treated HCC cell lines were investigated using real-time polymerase chain reaction array. Western blot PCR further evaluated c-Jun. Pathological specimens from 50 patients with...
// Peizhan Chen 1, * , Bin Li 2, 3, Yan Zhu 4, Wei 5 Xin Liu Mian 1 Xiaohua Duan Yi 3 Jinghan Wang 6 Xiangji Luo Xiaoguang Jingquan Lijian Liang Xiaoyu Yin Hui 7, 8 Xiaoqing Jiang Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes Biological Chinese Academy University Shanghai, 200031, P. R. China 2 Biliary Tract Surgery Department I, Eastern Hepatobiliary Hospital, Secondary Military Medical University, 200433, Diagnosis and Treatment Center...