A5115593149- Spectroscopy and Laser Applications
- Gas Sensing Nanomaterials and Sensors
- Cancer Cells and Metastasis
- Advanced Chemical Sensor Technologies
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Metal Extraction and Bioleaching
- Analytical Chemistry and Sensors
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Minerals Flotation and Separation Techniques
- Liver Disease and Transplantation
- PARP inhibition in cancer therapy
- Advanced MRI Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Dam Engineering and Safety
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Atmospheric and Environmental Gas Dynamics
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
- Ectopic Pregnancy Diagnosis and Management
Union Hospital
2025
Renmin Hospital of Wuhan University
2017-2025
Second Affiliated Hospital of Zhejiang University
2020-2025
Chinese Academy of Sciences
2022-2025
Hebei Agricultural University
2024-2025
Nanjing University of Aeronautics and Astronautics
2025
Wuhan University
2017-2025
Huazhong University of Science and Technology
2025
Zhejiang University of Technology
2025
Institute of Tibetan Plateau Research
2025
Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are resistant to radiation and chemotherapy, contribute relapse. Although several BCSC markers been described, it is unclear whether these identify the same or independent BCSCs. Here, we show BCSCs exist in distinct mesenchymal-like (epithelial-mesenchymal transition [EMT]) epithelial-like (mesenchymal-epithelial [MET]) states. Mesenchymal-like characterized as CD24−CD44+ primarily quiescent localized...
This paper examines the architectural and landscape design strategies intentions for green, open spaces facilities targeting stress alleviation learning environments such as those of university campuses in a compact urban setting. Literature reviews provide three prevailing perspectives physical pedagogical operatives: healing gardens where greenery plants produce restorative effects; flexible that accommodate functional needs different activities; green buildings incorporate space catalyst...
Abstract Liposomes are the first and mostly explored nanocarriers for cancer drug delivery, which have shown great promise in clinical applications, but their limited accumulation penetration into tumor interstitial space, significantly reduce therapeutic efficacy. Here, a γ‐glutamyltranspeptidase (GGT)‐triggered charge‐switchable approach is reported that can trigger fast endocytosis transcytosis of liposome microenvironments to overcome harsh biological barriers tissues. The active...
Abstract Suffusion involves fine particles migration within the matrix of coarse fraction under seepage flow, which usually occurs in gap‐graded material dams and levees. Key factors controlling soil erodibility include confining pressure ( p ′) fines content F c ), coupling effect on suffusion still remains contradictory, as concluded from different studies considering narrow scope these factors. For this reason, a systematical numerical simulation that considers relative wide range ′ was...
Electrostatic dielectric capacitors with ultrahigh power densities are sought after for advanced electronic and electrical systems owing to their ultrafast charge-discharge capability. However, low energy density resulting from breakdown strength suppressed polarization still remains a daunting challenge practical applications. We propose microstructural strategy dendritic nanopolar (DNP) regions self-assembled into an insulator, which simultaneously enhances high-field polarizability...
Most cancers contain abundant tumor-associated macrophages (TAMs). TAMs usually display a tumor-supportive M2-like phenotype; they promote tumor growth and influence lymphocyte infiltration, leading to immunosuppression. These properties have made an attractive cancer immunotherapy target. One promising immunotherapeutic strategy involves switching the tumor-promoting immune suppressive microenvironment by reprogramming TAMs. However, clinical trials of macrophage yielded unsatisfactory...
A silica based amino stationary phase was prepared by immobilization of propargylamine on azide-silica via click chemistry. This readily demonstrated good selectivity in separation common inorganic anions under ion chromatography (IC) mode, and the triazole ring combination with free group observed to play a major role for examined. On other hand, also showed hydrophilic interaction liquid (HILIC) properties polar compounds including nucleosides, organic acids bases. The retention mechanism...
Calcification roasting-acid leaching were conducted to investigate the extraction behavior of vanadium and chromium from high-chromium slag (HCVS). The conditions optimized by response surface methodology (RSM). Results showed that when HCVS CaO mixed in m(CaO)/m(V2O5) 0.62, then roasted room temperature 840 °C maintained for 170 min, a maximum rate 87.74% was achieved. Additionally, 0.68% co-leached, achieving separation chromium. roasting factors affecting followed this order:...
// Lichao Sun 1, 2, * , Joseph Burnett Mari Gasparyan 1 Fangying Xu Hui Jiang 3 Chang-Ching Lin Ila Myers Hasan Korkaya 4 Yajing Liu 5 Jamie Connarn Huining He 6 Ning Zhang Max S. Wicha Duxin Department of Pharmaceutical Sciences, University Michigan, Ann Arbor, MI, 48109, USA 2 State Key Laboratory Molecular Oncology, Cancer Hospital, Chinese Academy Medical Peking Union College, Beijing, 100021, China Biostatistics, Biochemistry and Biology, Georgia Regents University, Augusta, GA, 30912,...
Abstract Ultrasound‐targeted microbubble destruction (UTMD) mediates gene transfection with high biosafety and thus has been promising toward treatment of type 1 diabetes. However, the potential application UTMD in 2 diabetes (T2D) is still limited, due to lack systematic design dynamic monitoring. Herein, an efficient delivery system constructed by plasmid deoxyribonucleic acid (DNA) encoding glucagon‐like peptide (GLP‐1) ultrasound‐induced microbubbles, T2D macaque. The as designed...
Biofilms are physical barriers composed of extracellular polymeric substances (EPS) that enable planktonic bacteria to resist host responses and antibacterial treatments, complicating efforts clear such as Pseudomonas aeruginosa (P. aeruginosa) thereby contributing persistently chronic infections. As such, it is critical develop a robust antimicrobial strategy capable effectively eradicating P. biofilms further address aggressive clinical infection. In this study, ultrasound-activatable...
This study aimed to identify patients with pathological complete response (pCR) and make better clinical decisions by constructing a preoperative predictive model based on tumoral peritumoral volumes of multiparametric magnetic resonance imaging (MRI) obtained before neoadjuvant chemotherapy (NAC).This investigated MRI NAC in 448 nonmetastatic invasive ductal breast cancer (Sun Yat-sen Memorial Hospital, Sun University, n = 362, training cohort; University Cancer Center, 86, validation...
Medical diagnostic imaging is essential for the differential diagnosis of cervical lymphadenopathy. Here we develop an ultrasound radiomics method accurately differentiating lymph node tuberculosis (LNTB), lymphoma, reactive hyperplasia, and metastatic nodes especially in multi-operator, cross-machine, multicenter context. The inter-observer intra-observer consistency parameters from region interest were 0.8245 0.9228, respectively. model showed good repeatable performance multiple...
Resistance to trastuzumab and the poor efficacy of subsequent chemotherapy have become major challenges for HER2-positive gastric cancer (GC). As resistance evolves, tumor cells may acquire a new drug susceptibility profile, profoundly impacting treatment selection patient survival. However, interplay between other types drugs in GC remains elusive. In our study, we utilized resistant cell lines tissue specimens map profile trastuzumab-resistant GC, discovering that induces collateral...
Abstract Tuberculosis (TB) stands as the second most fatal infectious disease after COVID‐19, effective treatment of which depends on accurate diagnosis and phenotyping. Metabolomics provides valuable insights into identification differential metabolites for However, TB phenotyping remain great challenges due to lack a satisfactory metabolic approach. Here, metabolomics‐based diagnostic method rapid detection is reported. Serum fingerprints are examined via an automated nanoparticle‐enhanced...