A5101704481- Pregnancy and preeclampsia studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Gastric Cancer Management and Outcomes
- Sperm and Testicular Function
- Endometrial and Cervical Cancer Treatments
- Telomeres, Telomerase, and Senescence
- Reproductive Biology and Fertility
- Glioma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Autophagy in Disease and Therapy
Hainan Medical University
2020-2025
Southern Medical University
2015-2025
Nanfang Hospital
2015-2025
Second Affiliated Hospital of Nanjing Medical University
2024-2025
Tianjin Medical University
2025
Guangzhou Institutes of Biomedicine and Health
2025
Institute of Biophysics
2025
University of Chinese Academy of Sciences
2025
Zhejiang University
2024
Nanjing Medical University
2022-2024
Immune checkpoint blockade has led to breakthroughs in the treatment of advanced gastric cancer. However, prominent heterogeneity cancer, notably tumor microenvironment, highlights idea that antitumor response is a reflection multifactorial interactions. Through transcriptomic analysis and dynamic plasma sample analysis, we identified metabolic "face-off" mechanism within as shown by dual prognostic significance nicotinamide metabolism. Specifically, macrophages fibroblasts expressing...
Abstract Myocardial ischemia-reperfusion injury (MIRI) is involved in the pathogenesis of multiple cardiovascular diseases. This study elucidated biological function lysine acetyltransferase 5 (KAT5) cardiomyocyte pyroptosis during MIRI. Oxygen-glucose deprivation/reoxygenation and left anterior descending coronary artery ligation were used to establish MIRI models. Here we show, KAT5 STIP1 homology U-box-containing protein 1 (STUB1) downregulated, while large tumor suppressor kinase 2...
Abstract Background Metastasis and recurrence, wherein circulating tumour cells (CTCs) play an important role, are the leading causes of death in colorectal cancer (CRC). Metastasis-initiating CTCs manage to maintain intravascular survival under anoikis, immune attack, importantly shear stress; however, underlying mechanisms remain poorly understood. Methods In view scarcity bloodstream, suspended were flowed into cyclic laminar stress (LSS) according previous studies. Then, we detected...
Abstract Glioma is one of the most lethal cancers with highly vascularized networks and growing evidences have identified glioma stem cells (GSCs) to account for excessive angiogenesis in glioma. Aberrant expression paired-related homeobox1 (Prrx1) has been functionally associated cancer including GSCs. In this study, Prrx1 was found be markedly upregulated specimens elevated inversely correlated prognosis patients. potentiated stemness acquisition non-stem tumor (NSTCs) maintenance GSCs,...
Idiopathic pulmonary hypertension (IPAH) is a condition that affects various tissues and organs the metabolic inflammatory systems. The most prevalent syndrome (MS), which involves insulin resistance, dyslipidemia, obesity. There may be connection between IPAH MS, based on plethora of studies, although underlying pathogenesis remains unclear. Through bioinformatics analyses machine learning algorithms, we identified 11 immune- metabolism-related potential diagnostic genes (EVI5L, RNASE2,...
Resistance to trastuzumab and the poor efficacy of subsequent chemotherapy have become major challenges for HER2-positive gastric cancer (GC). As resistance evolves, tumor cells may acquire a new drug susceptibility profile, profoundly impacting treatment selection patient survival. However, interplay between other types drugs in GC remains elusive. In our study, we utilized resistant cell lines tissue specimens map profile trastuzumab-resistant GC, discovering that induces collateral...
The gut microbiota has a significant impact on the development and function of intestinal epithelial cells (IECs) by modifying bile acid (BA) metabolites. Recently, specific microbiome-derived BAs, such as 7-oxo-deoxycholic (7-oxo-DCA) isodeoxycholic (isoDCA), have been identified to be shifted inversely in colitis hepatic liver diseases. Although responsible microbes identified, metabolites’ effects IECs remain largely unclear. We found that although high-fat diet treatment mice elevated...
Stomatin-like protein 2 (SLP-2, also known as STOML2) is a stomatin homologue of uncertain function. SLP-2 overexpression has been suggested to be associated with cancer progression, resulting in adverse clinical outcomes patients. Our study aim investigate expression epithelial ovarian cells and its correlation patient survival.SLP-2 mRNA levels were analysed five cell lines normal using real-time PCR western blotting analysis. was investigated eight matched-pair samples adjacent...
Smoking is an important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), which commonly characterised by cellular senescence and inflammation. Recently, miR-200b has emerged as target to cure lung disease; however, function reducing inflammatory responses not been reported. In this study, we found that was downregulated lungs COPD model mice, its expression correlated with responses. We hypothesised may be a potential novel therapy for treating COPD. performed...
Long non-coding RNAs (lncRNAs) have been indicated to play critical roles in gastric cancer (GC) tumorigenesis and progression. However, their GC remain be further elucidated.RT-qPCR fluorescence situ hybridzation (FISH) were conducted detect the expression of lncRNA NEAT1 tissues cell lines. Gene Set Enrichment Analysis (GSEA) was performed screen out potential phenotypes pathways that may participate in. NEAT1-silenced AGS MGC803 cells constructed a series functional experiments...
Dysregulated epithelial-mesenchymal transition (EMT) is involved in cervical cancer metastasis and associated with histone acetylation. However, the underlying molecular mechanisms of acetylation EMT are still elusive.We systematically investigated expression patterns genes their correlations pathway cancer. The CSRP2BP among tissues cell lines was detected using Western blotting immunohistochemistry analyses. effects on proliferation tumorigenicity were examined by growth curve, EdU assay,...
<title>Abstract</title> Gastric cancer (GC) is a highly malignant tumor, and oxaliplatin widely used in its chemotherapy. However, drug resistance limits clinical effectiveness. This study aimed to identify potential therapeutic strategies overcome GC. RNA sequencing was conducted compare oxaliplatin-resistant GC cells with their parental counterparts. Using the Limma package, we identified an immunosuppressive microenvironment six key transcription factors associated resistance, ATOH8...
Currently, no objective indicators are available to predict the optimal timing for laryngeal mask insertion. Anesthesia depth monitoring devices such as Bispectral Index (BIS) not widely applicable day-surgery patients due their high cost. Previous literature has reported a correlation between perfusion index (PI) and anesthesia depth. Thus, aim of this study is verify whether PI can serve an indicator predicting This trial was conducted at specialized pediatric hospital, with final...
Radiomics refers to the utilization of automated or semi-automated techniques extract and analyze numerous quantitative features from medical images, such as computerized tomography (CT) magnetic resonance imaging (MRI) scans. This study aims develop a deep learning radiomics (DLR)-based approach for predicting programmed death-ligand 1 (PD-L1) expression in patients with non-small cell lung cancer (NSCLC). Data 352 NSCLC known PD-L1 were collected, which 48.29% (170/352) tested positive...
Small extracellular vesicles (sEVs) are important mediators of cell-to-cell communication involved in the successful establishment a pregnancy. Human decidual stromal cells play key role regulating trophoblast invasion. Nevertheless, regulatory functions cells-derived sEVs human still unclear. In this study, primary were isolated, and immortalized endometrial cell line (HESCs) decidualized into (HDSCs) using hormonal cocktail containing medroxy progesterone 17-acetate (MPA), estrogen cAMP...
SET and MYND domain-containing protein 1 (Smyd1) is a striated muscle-specific histone methyltransferase. Our previous work demonstrated that deletion of Smyd1 in either cardiomyocytes or the outflow tract (OFT) resulted embryonic lethality at E9.5, with cardiac structural defects such as truncation OFT right ventricle impaired expansion proliferation second heart field (SHF). The phenotype was accompanied by downregulation ISL LIM Homeobox (Isl1) upregulation atrial natriuretic factor...
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance epithelial growth factor receptor (EGFR) Kirsten rat sarcoma viral oncogene (KRAS) mutations prognosis PPMA. A total 29 patients with PPMA from among 1,469 surgically resected were enrolled. All tumours expressed CK7 5 cases exhibited co-expression CK20. 8 EGFR, 14 P53 2 CEA....
Acylglycerol kinase (AGK) had been shown to contribute cancer progression and unfavorable clinical outcomes of patients. Our study aimed investigate the expression pattern significance AGK in patients with early-stage cervical squamous cell (CSCC). The protein messenger RNA (mRNA) was analyzed six lines four paired CSCC specimens normal tissues (NCT), using Western blotting real-time PCR (RT-PCR). And we investigated paraffin-embedded from 140 30 cases NCT by immunohistochemistry (IHC)....
Abstract Early‐onset preeclampsia (PE) is a pregnancy complication that can lead to severe adverse maternal and fetal outcomes. However, the mechanisms underlying development of early‐onset PE are not fully understood. Ribosomal protein L39 (RPL39) member S39E family ribosomal proteins plays an important role in stem cell self‐renewal, cancer metastasis, chemoresistance. In this study, we aimed explore potential function RPL39 placental trophoblast cells. We analyzed expression normal...
Metastatic microsatellite-stable (MSS) colorectal cancer rarely responds to immune checkpoint inhibitors (ICI). Metabolism heterogeneity in the tumor microenvironment (TME) presents obstacles antitumor response. Combining transcriptome (The Cancer Genome Atlas MSS cancer, n = 383) and digital pathology (n 96) analysis, we demonstrated a stroma metabolism-immune excluded subtype with poor prognosis which could be attributed interaction between chondroitin-6-sulfate (C-6-S) metabolites M2...