A5101724226- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Lipid metabolism and disorders
- Microtubule and mitosis dynamics
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Renal and related cancers
- Chemokine receptors and signaling
- Aldose Reductase and Taurine
- Organoselenium and organotellurium chemistry
- Intracranial Aneurysms: Treatment and Complications
- Autophagy in Disease and Therapy
- Redox biology and oxidative stress
- Glycosylation and Glycoproteins Research
- Mechanisms of cancer metastasis
- Barrier Structure and Function Studies
Southern Medical University
1997-2025
Third Affiliated Hospital of Southern Medical University
2017-2025
Guangdong Provincial People's Hospital
2020-2025
Guangdong Academy of Medical Sciences
2020-2025
Beihua University
2024
Guangzhou University
2022-2023
Guangzhou University of Chinese Medicine
2014-2023
Key Laboratory of Guangdong Province
2022-2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2011-2022
Harbin Medical University
2012
Cancer-derived exosomes are considered a major driver of cancer-induced pre-metastatic niche formation at foreign sites, but the mechanisms remain unclear. Here, we show that miR-25-3p, metastasis-promoting miRNA colorectal cancer (CRC), can be transferred from CRC cells to endothelial via exosomes. Exosomal miR-25-3p regulates expression VEGFR2, ZO-1, occludin and Claudin5 in by targeting KLF2 KLF4, consequently promotes vascular permeability angiogenesis. In addition, exosomal dramatically...
Centromere Protein F (CENPF) associates with the centromere-kinetochore complex and influences cell proliferation metastasis in several cancers. The role of CENPF breast cancer (BC) bone remains unclear.Using ONCOMINE database, we compared expression normal tissues. Findings were confirmed 60 BC patients through immunohistochemical (IHC) staining. Microarray data from GEO Kaplan-Meier plots used analyze overall survival (OS) relapse free (RFS). Using databases, primary lesions, lung lesions...
Oxidative stress plays an important role in the pathology of ischemic stroke. Studies have confirmedthat scutellarin has antioxidant effects against injury, and we also reported that involvement Aldose reductase (AR) oxidative cerebral this study furtherly explicit whether effect on ischemia injury is related to AR gene regulation its specific mechanism.C57BL/6N mice (Wild-type, WT) knockout (AR-/-) suffered from transient middle artery occlusion (tMCAO) (1 h followed by 3 days reperfusion),...
Abstract Background The X-linked gene WTX (also called AMER1) has been reported to function as a tumour suppressor in Wilms’ tumour. In our previous study, expression was shown be significantly reduced gastric cancer (GC), but the and mechanism associated with loss had yet fully elucidated. Methods clinical significance were father analyzed GC control normal tissues, validated public databases. candidate pathway which regulated by during progression searched KEGG analysis. miRNA monitored...
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and second leading cause of cancer‑related mortality worldwide according to Global Cancer Statistics 2018. Resveratrol (RSV) a phenolic compound that possesses anticancer functions against various types cancer, including breast gastric cancer. However, mechanism underlying RSV in CRC are not completely understood. The present study aimed investigate effects cells by conducting Cell Counting Kit‑8, apoptosis, reactive...
Highlights•miR-1825 is upregulated in CRC and associated with progression•circTBC1D22A functions as an efficient miR-1825 sponge cells•ATG14 functional target of cells•circTBC1D22A regulates autophagy via miR-1825/ATG14 axisSummaryDistant metastasis the main cause death patients colorectal cancer (CRC). A better understanding mechanisms can greatly improve outcome CRC. Accumulating evidence suggests that circRNA plays pivotal roles progression metastasis, especially acting a miRNA to...
Colorectal cancer liver metastases (CRLM) are the primary cause of mortality in colorectal (CRC) patients, highlighting importance understanding underlying mechanisms. The tumor microenvironment (TME) and its interaction with cells play a crucial role CRLM progression. Notably, stability peak levels tumor-derived exosomal miRNAs facilitate intercellular communication TME. Hepatic stellate (HSCs), key mesenchymal cells, constitute about 33% liver's nonsolid cell population exhibit plasticity....
Abstract Background and Purpose Subarachnoid hemorrhage ( SAH )‐induced cerebral vasospasm early brain injury is a fatal clinical syndrome. Cerebral are associated with inflammatory response oxidative stress. Whether curcumin, which plays important roles to regulate cytokines inhibit stress, inhibits ‐induced inflammation stress largely unknown. Methods Adult male rats underwent autologous blood injection into prechiasmatic cistern induce . Curcumin (150 mg/kg) was administered at 0.5, 24 48...
Objectives: Atherosclerosis is an important cause of stroke and remains a challenge for prevention. Risk factors involved in atherosclerotic anterior posterior circulation strokes (ACS PCS, respectively) are different. The purpose this study to investigate differences risk between intracranial extracranial atherosclerosis (ICAS ECAS), ACS ICAS/ECAS with ACS/PCS Chinese acute ischaemic population. Methods: We analysed 551 patients who had been enrolled August 2005 July 2008. First, were...
Long non-coding RNAs (lncRNAs) have been indicated to play critical roles in gastric cancer (GC) tumorigenesis and progression. However, their GC remain be further elucidated.RT-qPCR fluorescence situ hybridzation (FISH) were conducted detect the expression of lncRNA NEAT1 tissues cell lines. Gene Set Enrichment Analysis (GSEA) was performed screen out potential phenotypes pathways that may participate in. NEAT1-silenced AGS MGC803 cells constructed a series functional experiments...
Gastric cancer (GC) is one of the most prevalent and lethal cancers worldwide. Ferroptosis a form iron-dependent regulated cell death emerging as promising strategy for therapy, whereas regulation mechanism remains unclear. WTX has been recognized potential tumor suppressor, but attempts at targeted therapy have not achieved substantial progress. Further research into structure, function, mechanisms urgently needed. Herein, we identified long isoform (WTX-L) potent ferroptosis effector in...
Vascular etiology is the second most prevalent cause of cognitive impairment globally. Endothelin-1, which produced and secreted by endothelial cells astrocytes, implicated in pathogenesis stroke. However, way changes astrocytic endothelin-1 lead to poststroke deficits following transient middle cerebral artery occlusion not well understood. Here, using mice was overexpressed, we found that selective overexpression led ischemic stroke-related dementia (1 hour ischemia; 7 days, 28 or 3 months...
Bone metastasis (BM) is the advanced complication of breast cancer, while bone marrow-derived mesenchymal stem cells (BMSCs) in microenvironment unclearly contribute to cancer metastasis. This study investigated potential roles transforming growth factor- (TGF-) α interaction between and BMSCs BM. Clinical cases with (BMBC), without (Non-BM-BC), benign fibroadenoma (Benign) were enlisted a retrospective study. TGF- was found obviously overexpressed BM lesion BMBC compared primary both...
Aim: Epilepsy is a common and serious neurological disease that causes recurrent episodes, but its molecular mechanism remains unclear. Abnormal miRNA expression associated with epilepsy, including miR-451. This research investigated the role of miR-451 in seizure detailed mechanism. Methods: The mice model was induced by kainic acid (KA) injection to right lateral cerebral ventricle. Behavioral changes were observed evaluated Racine Scale. knockout established adenovirus infection. vitro...
Tongxinluo has been widely used in China for the treatment of acute stroke and neuroprotection. However, there are few positron emission tomography (PET) studies on neuroprotective effect cerebral ischemia/reperfusion small animals. In present study, superfine powder suspension or its vehicle was administered intragastrically to rats 5 successive days before middle artery occlusion. (18)F-fluorodeoxyglucose (FDG) animal PET imaging showed that at 1 2 weeks after ischemia/reperfusion, glucose...
Distant metastasis is the primary barrier for successful treatment of patients with colorectal cancer, and thus, searching new therapeutic targets by further exploring molecular mechanisms cancer important. In this study, we investigated biological clinical significance RASSF6 in as well underlying mechanisms. We found that low expression corresponds to a poor prognosis patients, distinctly associated tumour progression. Our vitro analysis revealed suppresses proliferation DLD1 cells,...
The high expression of c-jun and neuronal nitric oxide synthase (nNOS) generally occurs in neurons following the generation various animal models central diseases. However, mechanism between them disease remains to be elucidated. Our previous studies demonstrated that c‑jun always prior nNOS motoneuron injuries suppression by siRNA decreased differentiated PC12 cells. present study aimed examine whether there was an association up downstream regulation or crosstalk neurons. Using a culture...
To investigate the expression of cell division- associated gene NUF2 in breast cancer and its clinical significance.The tissues was analyzed using Oncomine database. The relationship between prognosis Kaplan-Meier Plotter Gene set enrichment analysis (GSEA) GEO database were used to effect on enrichment. String utilized analyze proteins with NUF2. TIMER assess correlations BUB1, MAD2L1 MYC. expressions mRNA 8 pairs adjacent verified by q-PCR.Compared that normal tissue, significantly...