A5074267272- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Bone Metabolism and Diseases
- Traditional Chinese Medicine Analysis
- Drug Transport and Resistance Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Cardiac Ischemia and Reperfusion
- Drug-Induced Hepatotoxicity and Protection
- Bone health and treatments
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Cell death mechanisms and regulation
- Ginseng Biological Effects and Applications
- Pancreatitis Pathology and Treatment
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Biological and pharmacological studies of plants
- Sirtuins and Resveratrol in Medicine
- Phosphorus and nutrient management
- Alkaloids: synthesis and pharmacology
- Computational Drug Discovery Methods
Tianjin University of Traditional Chinese Medicine
2014-2024
Southwest University
2024
Tianjin haihe hospital
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Third Affiliated Hospital of Southern Medical University
2017-2021
Cancer-derived exosomes are considered a major driver of cancer-induced pre-metastatic niche formation at foreign sites, but the mechanisms remain unclear. Here, we show that miR-25-3p, metastasis-promoting miRNA colorectal cancer (CRC), can be transferred from CRC cells to endothelial via exosomes. Exosomal miR-25-3p regulates expression VEGFR2, ZO-1, occludin and Claudin5 in by targeting KLF2 KLF4, consequently promotes vascular permeability angiogenesis. In addition, exosomal dramatically...
Centromere Protein F (CENPF) associates with the centromere-kinetochore complex and influences cell proliferation metastasis in several cancers. The role of CENPF breast cancer (BC) bone remains unclear.Using ONCOMINE database, we compared expression normal tissues. Findings were confirmed 60 BC patients through immunohistochemical (IHC) staining. Microarray data from GEO Kaplan-Meier plots used analyze overall survival (OS) relapse free (RFS). Using databases, primary lesions, lung lesions...
Abstract Gypenoside XVII (GP‐17), a tetracyclic triterpene saponin isolated from the functional food Gynostemma pentaphyllum , has been demonstrated protective effects against cerebrovascular and cardiovascular diseases on multiple disease models. In this study, we established myocardial infarction (MI) model by ligating left anterior descending coronary artery, explored whether GP‐17 prevent ischemia/reperfusion (I/R) injuries in mice. Compared with I/R group, significantly improved cardiac...
Psoralen and bakuchiol are the main active compounds found in traditional Chinese medicine Psoralea corylifolia L., have been used to treat osteoporosis. This study aims investigate anti-osteoporosis effects of these two using osteoclasts precursor differentiation bone absorption assays vitro.Primary mouse cells were induced by M-CSF (macrophage colony stimulating factor) plus RANKL (receptor activator nuclear factor kappa-B ligand) vitro. TRACP (tartrate-resistant acid phosphatase) enzyme...
Osteoporosis is a systemic skeletal disease, which characterized by destruction of bone mass and microarchitecture. With life standard improved, the treatment osteoporosis attracted more attention. The aim this study to verify osteoprotective effect psoralen isopsoralen in females males. Female male mice were divided into 7 groups study: control group (sham-operation), model (by ovariectomy or orchidectomy), positive (females given estradiol valerate; males alendronate sodium), (10 mg/kg 20...
Psoralen has potential hepatotoxicity and a certain promoting effect on the clinical liver injury of Psoralea corylifolia L (Fructus Psoraleae). This study investigated underlying mechanisms psoralen-induced in vitro. HepG2 cells were treated with psoralen for 6, 12, 24, or 48 h, an endoplasmic reticulum (ER) stress-specific inhibitor, 4-PBA, was employed to investigate mechanism ER stress unfolded protein response (UPR). Cell viability tested by MTT assay, ATP cell death LDH. The apoptosis...
Abstract F-box only protein 8 (FBX8), as a critical component of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases, has been associated with several malignancies through interacting member proteins. However, substrates FBX8 for destruction in progression colorectal carcinoma (CRC) need to be explored. Here, we show that loss accelerates chemical-induced colon tumorigenesis. directly targets GSTP1 ubiquitin-mediated proteasome degradation CRC. promotes proliferation, invasion, and metastasis CRC...
Objectives Shen Fu Injection (SF), which consisted of Red ginseng extraction injection (RG) and prepared aconite (RA), is a traditional Chinese medicine mainly used for various cardiac diseases. This study to analyse SF's effects on performance coronary circulation. And the dilating effect mechanism above three injections were also explored. Methods Mature male guinea pigs as our animal model. We employed two types perfusion methods (constant pressure constant flow) in vitro, using...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) associated with an increased risk PDAC, partly due to acinar‐to‐ductal metaplasia (ADM). Baicalein been shown exert anti‐inflammatory and anti‐tumor effects for CP or respectively. The aim our study was investigate effect baicalein, putative underlying mechanism, on inflammatory cytokines‐induced ADM rat pancreatic acinar cell line AR42J. To baicalein...
Pre-clinical safety evaluation of traditional medicines is imperative because the universality drug-induced adverse reactions. Psoralen and isopsoralen are major active molecules quality-control components a herbal medicine which popularly used in Asia, Fructus Psoraleae. The purpose this study to assess long-term effects psoralen with low levels on biochemical parameters metabolic profiles rats. Three doses (14, 28, 56 mg/kg) one dose (28 were administered rats over 12 weeks. Blood selected...
Abstract The role of the LMNA gene in development and progression hepatocellular carcinoma (HCC) associated molecular mechanism is not yet clear. Therefore, purpose this study was to evaluate relationship between HCC. expression normal tissues corresponding tumours evaluated Kaplan–Meier survival analysis performed. Next, knocked out 293T HepG2 cell lines using CRISPR/Cas9 technique. Subsequently, proliferation, migration colony formation rate two knockout were analysed. Finally, affecting...
The aim of the present study was to investigate protective effects Shenfu injection (SFI) against myocardial ischemia-reperfusion injury (MIRI) in model rats and explore its mechanism action. Sprague-Dawley (SD) were pretreated with SFI NG-nitro-L-arginine methyl ester (L-NAME) via tail vein then subjected ischemia by occlusion left anterior descending coronary artery for 30 min followed reperfusion 120 min. Left ventricular function evaluated echocardiography. Hemodynamic measured Millar...
Psoralen is the main active component of Psoralea corylifolia and used as a marker to assess its quality. The effects psoralen on animals have been well characterized. However, molecular pathway toxicity not fully understood. In this study, toxic administration (60 mg/kg) for 7 days in Sprague–Dawley rats were observed. Serum biochemistry liver histopathology further investigated. Proton nuclear magnetic resonance was applied characterize metabolic profile induced by find changed metabolites...
Abstract Background The main bioactive components of Fructus psoraleae, such as psoralen and isopsoralen, are known to be hepatotoxic. However, its underlying mechanism is elucidated. Methods To address this, SD rats were randomly divided into control group, 60 mg/kg group isopsoralen group. Blood was collected detect serum biochemical indices. RNA extracted from liver samples, then, cDNA gene expression profiles analysed. Results Psoralen administration significantly up‐regulated AST...
This study was performed to determine the optimal window of time during which properties osteoporosis are obvious and explore best region interest for microstructural evaluation in antiosteoporosis research an ovariectomized mouse model by examining changes micro-computed tomography parameters serum indices. Ovariectomized mice sham-operated were randomly divided into five groups. At end 4th, 8th, 12th, 16th, 20th weeks after ovariectomy, microstructure proximal tibia distal femur scanned...
Abstract A method for the simultaneous quantification of 13 bioactive compounds (psoralen, isopsoralen, isobavachin, bakuchalcone, neobabaisoflavone, bavachin, corylin, psoralidin, isobavachalcone, bavachinin, corylifol A, bavachalcone, and bakuchiol) by ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry has been developed validated in rat plasma. Osthol was used as an internal standard plasma samples were pretreated one‐step liquid–liquid...
The purpose of this research was to extract and separate the compounds from frankincense, then evaluate their anti-inflammatory effects. isolated compound a representative tetracyclic triterpenes glycine structure according 1H-NMR 13C-NMR spectra, which is β-elemonic acid (β-EA). We determined content six different localities frankincense; average β-EA 41.96 mg/g. toxic effects administration (400, 200, 100 mg/kg) for four weeks in Kunming (KM) mice were observed. Compared with control...