A5102875063- Endometrial and Cervical Cancer Treatments
- Esophageal and GI Pathology
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Mitochondrial Function and Pathology
- Cervical Cancer and HPV Research
- Neonatal and fetal brain pathology
- Dysphagia Assessment and Management
- Functional Brain Connectivity Studies
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Anesthesia and Neurotoxicity Research
- Lung Cancer Research Studies
- Immune cells in cancer
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Tryptophan and brain disorders
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Stress Responses and Cortisol
- Medical Research and Treatments
Wuhan University
2013-2025
First Affiliated Hospital of Soochow University
2025
Sun Yat-sen University
2015-2025
Sun Yat-sen University Cancer Center
2013-2025
The First Affiliated Hospital, Sun Yat-sen University
2017-2025
Zhongshan Hospital
2025
Fudan University
2025
Soochow University
2025
University of Electronic Science and Technology of China
2025
Renmin Hospital of Wuhan University
2023-2025
Camrelizumab is an antibody against programmed death protein 1. We assessed the activity and safety of camrelizumab plus apatinib, a tyrosine kinase inhibitor vascular endothelial growth factor receptor-2, in patients with advanced cervical cancer.
// Yosuke Konno 1,* , Peixin Dong 2,* Ying Xiong 3,* Fumihiko Suzuki 4,* Jiabin Lu 5 Muyan Cai Hidemichi Watari 1 Takashi Mitamura Masayoshi Hosaka Sharon J. B. Hanley 2 Masataka Kudo and Noriaki Sakuragi 1,2 Department of Gynecology, Hokkaido University, Sapporo, Japan Women's Health Educational System, 3 State Key Laboratory Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China 4 Obstetrics Tohoku Sendai, Pathology, * These authors contributed equally to...
Breast carcinoma is the most common female cancer with considerable metastatic potential. Discovery of new therapeutic approaches for treatment breast still needed. Here, we reported our finding niclosamide, an FDA approved anthelmintic drug. The potency niclosamide on was assessed in vitro and vivo. In this investigation, found that showed a dramatic growth inhibition against cell lines induced apoptosis 4T1 cells dose-dependent manner. Further, Western blot analysis demonstrated occurrence...
<b>Background and study aim:</b> Although the majority of submucosal tumors (SMTs) are benign, some do have a malignant potential. Resection SMTs would aid in establishing diagnosis may be curative. Our aim was to examine feasibility safety novel method for endoscopic resection upper gastrointestinal SMTs. <b>Patients methods:</b> In 12 patients who presented with an SMT ≤ 40 mm located esophagus or cardia, tunnel endoscopically created starting approximately 5 cm proximal lesion. After...
Diabetic neuropathy (DN) is a prevalent and painful complication of diabetes; however, the mechanisms underlying its pathogenesis remain unclear, effective clinical treatments are lacking. This study aims to explore role peroxisomes in Schwann cells DN. The abundance sciatic nerves mice or was analyzed using laser confocal super-resolution imaging western blotting. RFP-GFP-SKL (Ser-Lys-Leu) probe utilized assess pexophagy (peroxisomes autophagy) levels. To evaluate palmitoylation PEX11B,...
This research focused on investigating the relationship between Node Reporting and Data System (Node-RADS) categories, determined via preoperative CT, outcomes of progression-free survival (PFS) cancer-specific (CSS) in individuals diagnosed with papillary renal cell carcinoma (pRCC). A retrospective multicenter study initially enrolled 454 patients, 218 eligible for analysis following partial nephrectomy or radical resection pRCC. Prognostic factors related to PFS CSS pRCC patients were...
Abstract Colorectal carcinoma (CRC) is the one of most common cancers with considerable metastatic potential, explaining need for new drug candidates that inhibit tumor metastasis. The signal transducers and activators transcription 3 (Stat3) signaling pathway has an important role in CRC been validated as a promising anticancer target therapy. In present study, we report our findings on nifuroxazide, antidiarrheal agent identified inhibitor Stat3. Our studies showed nifuroxazide decreased...
Intrinsic signal optical imaging with red illumination (ISOI) is used extensively to provide high spatial resolution maps of stimulus-evoked hemodynamic-related signals as an indirect means map evoked neuronal activity. This generally described beginning undershoot or “dip” in that faster, more transient, and weaker compared the subsequent overshoot. In contrast, detected blood oxygen level-dependent (BOLD) functional magnetic resonance (fMRI) containing after initial dip overshoot, even...
This is a phase Ib study of anlotinib plus programmed death-ligand 1 (PD-L1) inhibitor TQB2450 for platinum-resistant or -refractory ovarian cancer. Thirty-four patients are enrolled and receive treatment. The objective response rate (ORR) 47.1%, the disease control 97.1%. median duration (DOR) has not been reached, 61.3% have DOR at least 8 months. progression-free survival (PFS) 7.8 months, overall (OS) reached. PD-L1-positive group an ORR 25.0%, whereas PD-L1-negative 92.9%....
Rhythmic intraorgan communication coordinates environmental signals and the cell-intrinsic clock to maintain organ homeostasis. Hepatocyte-specific KO of core components molecular Rev-erbα -β (Reverb-hDKO) alters cholesterol lipid metabolism in hepatocytes as well rhythmic gene expression nonparenchymal cells (NPCs) liver. Here, we report that fatty liver caused by diet-induced obesity (DIO), hepatocyte SREBP cleavage–activating protein (SCAP) was required for Reverb-hDKO–induced diurnal...
Background: AZD4547, a small-molecule inhibitor targeting the tyrosine kinase of Fibroblast Growth Factor Receptors (FGFRs), is currently under phase II clinical study for human subjects having breast cancer, while underlying mechanism remains elusive. The aim this to explore potential by which AZD4547 inhibits tumor lung metastases at level microenvironment. Methods: First, through in vitro experiments, we investigated efficacy FGFRs on 4T1 cells their proliferation, apoptosis, migration,...
Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) are beneficial to lung adenocarcinoma patients with sensitive mutations, resistance these induces a cancer stem cell (CSC) phenotype. Here, we clarify the function and molecular mechanism of shisa3 as suppressor that can reverse EGFR-TKI inhibit CSC properties. The suppresser genes involved in were identified validated by transcriptome sequencing, quantitative real-time PCR (qRT-PCR) immunohistochemistry. Biological analyses, half maximal...
Early life stress (ELS) is associated with the later development of schizophrenia. In rodent model, maternal separation (MS) may induce neuronal apoptosis and schizophrenia-like behavior. Although TRPV1 agonist capsaicin (CAP) has been reported to reduce in central nervous system, its effect MS models unclear. Twenty-four hours Wistar rat pups on postnatal day (PND9) was used as an ELS. Male rats adult stage were subjects study. CAP (1 mg/kg/day) intraperitoneal injection pretreatment...
Osteosarcoma is a very serious primary bone cancer with high death rate and dismal prognosis. Since there no permanent therapy for this condition, it necessary to develop cure. Therefore, investigation was carried out assess the impacts biological functions of hydroxysafflor yellow A (HYSA) in osteosarcoma cell lines (MG63). In investigational study, MG63 cells were utilized. Microarray experiments, quantitative polymerase chain reaction (qPCR), immunofluorescent staining, extracellular...
BACKGROUND Currently, adolescent depression is one of the most significant public health concerns, markedly influencing emotional, cognitive, and social maturation. Despite advancements in distinguish neurobiological substrates underlying depression, intricate patterns disrupted brain network connectivity adolescents warrant further exploration. AIM To elucidate neural correlates by examining using resting-state functional magnetic resonance imaging (rs-fMRI). METHODS The study cohort...
Abstract Over the past decade, digital twin brain (DTB) has emerged as a transformative science paradigm, integrating multimodal data to construct dynamic models closely simulating biological function. This approach advanced understanding of structure–function relationships, cognitive behaviors, and disease mechanisms, while supporting personalized therapies. Recent progress highlights DTB’s potential in capturing functional heterogeneity, information integration, predicting individual...
Abstract Background With obesity as a risk factor for atherosclerotic disease, recent research suggests that adipose tissue in obese animal models and humans can generate endocrine-like molecules affect arterial health later on. Previous studies showed microRNA-30e (miR-30e) level is elevated atherosclerosis solute carrier family 7 member 11 (SLC7A11), cystine/glutamate transporter, involved atherogenesis. However, whether an link between the adipose-derived miR-30e-5p SLC7A11 vascular...