A5101917605- Lung Cancer Research Studies
- Ovarian cancer diagnosis and treatment
- Pneumonia and Respiratory Infections
- Cancer, Hypoxia, and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Endometrial and Cervical Cancer Treatments
- Cardiac Arrhythmias and Treatments
- Cytokine Signaling Pathways and Interactions
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Systemic Lupus Erythematosus Research
- Peptidase Inhibition and Analysis
- Dermatological and COVID-19 studies
- Sports injuries and prevention
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Effects of Exercise
- Parkinson's Disease and Spinal Disorders
- Neuroendocrine Tumor Research Advances
- Vasculitis and related conditions
- Growth Hormone and Insulin-like Growth Factors
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders
- Cervical Cancer and HPV Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Chongqing Cancer Hospital
2013-2022
Chongqing University
2021-2022
Wenzhou Medical University
2021-2022
First Affiliated Hospital of Wenzhou Medical University
2021-2022
Taipei Medical University-Shuang Ho Hospital
2015-2019
Mackay Memorial Hospital
2019
Chung Shan Medical University
2015
Cancer Institute (WIA)
2013
This is a phase Ib study of anlotinib plus programmed death-ligand 1 (PD-L1) inhibitor TQB2450 for platinum-resistant or -refractory ovarian cancer. Thirty-four patients are enrolled and receive treatment. The objective response rate (ORR) 47.1%, the disease control 97.1%. median duration (DOR) has not been reached, 61.3% have DOR at least 8 months. progression-free survival (PFS) 7.8 months, overall (OS) reached. PD-L1-positive group an ORR 25.0%, whereas PD-L1-negative 92.9%....
Insulin-like growth factors (IGFs) stimulate and differentiation of osteoblasts in culture, these biological functions can be modulated by their binding proteins (IGFBPs). Previous studies have shown that IGFBP-2 is the major IGFBP synthesized fetal rat osteoblast-like (ROB) cells, which also secret a minor 24-kilodalton IGFBP, presumably IGFBP-4. In this study we examined modulation abundance IGFBPs various factors. By immunoprecipitation ligand blotting, proved 24 kilodalton protein,...
The association between Parkinson's disease (PD) and stroke remains completely understood.We aimed to investigate risk post-stroke outcomes in patients with PD.The retrospective cohort study included 1303 aged ≥ 40 years new-diagnosed PD 5212 non-PD adults were selected by frequency matching age sex 2000-05. Both two groups followed up until the end of 2013. Another nested 17 678 hospitalization 2002-09 was conducted compare admission outcome without history.We collected patients'...
Objective This study examined the predictive utility of DNA methylation for cervical cancer recurrence. Methods and RNA expression data patients with were downloaded from The Cancer Genome Atlas. Differentially methylated genes (DMGs) differentially expressed screened extracted via correlation analysis. A support vector machine (SVM)-based recurrence prediction model was established using selected DMGs. Cox regression analysis receiver operating characteristic curve used self-evaluation....
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5557 Background: Combination of antiangiogenic therapy and immune checkpoint inhibitor is reported as an effective antitumor strategy. TQB2450 a humanized IgG1 monoclonal antibody against programmed death-ligand 1 (PD-L1). We aimed to assess the activity safety plus multi-target tyrosine kinase anlotinib in patients with recurrent advanced ovarian cancer. Methods: The study ClinicalTrials.gov identifier NCT04236362 open-label, multicohort, multicenter phase Ib trial evaluating efficacy...