A5100346270- Tea Polyphenols and Effects
- Alzheimer's disease research and treatments
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antifungal resistance and susceptibility
- Neuroinflammation and Neurodegeneration Mechanisms
- Endometriosis Research and Treatment
- Advanced Breast Cancer Therapies
- Pancreatic function and diabetes
- Food Quality and Safety Studies
- Tryptophan and brain disorders
- Radiomics and Machine Learning in Medical Imaging
- Antibiotic Resistance in Bacteria
- Phytochemicals and Antioxidant Activities
- Cancer-related molecular mechanisms research
- Intensive Care Unit Cognitive Disorders
- Pomegranate: compositions and health benefits
- Anesthesia and Neurotoxicity Research
- Melanoma and MAPK Pathways
- Occupational and environmental lung diseases
- Colorectal Cancer Treatments and Studies
- Nanoplatforms for cancer theranostics
- Antibiotic Use and Resistance
Peking University
2009-2025
Peking University Third Hospital
2023-2025
Sichuan University
2014-2025
State Key Laboratory of Oral Diseases
2025
Yunnan Agricultural University
2012-2024
Hunan Normal University
2019-2024
Huazhong Agricultural University
2018-2024
Huazhong University of Science and Technology
2014-2024
Hefei University of Technology
2020-2024
Tongji Hospital
2024
Oncogenic TRK fusions induce cancer cell proliferation and engage critical cancer-related downstream signaling pathways. These occur rarely, but in a diverse spectrum of tumor histologies. LOXO-101 is an orally administered inhibitor the kinase highly selective only for family receptors. Preclinical models using TRK-fusion-bearing human-derived lines demonstrate inhibition fusion oncoprotein cellular vitro, growth vivo. The 41-year-old woman with soft-tissue sarcoma metastatic to lung was...
TP53 tumor-suppressor gene mutations are among the most frequent abnormalities in cancer, affecting approximately 40% of patients. Yet, there is no accepted way to target these alterations clinic. At same time, antagonists VEGFR or its ligand best-selling oncology drugs, with multiple, expensive compounds approved. Although only a subset patients benefit from antiangiogenesis agents, relevant biomarker has been identified. Interestingly, upregulate VEGF-A and VEGFR2. We prospectively...
Alzheimer's disease (AD), also known as senile dementia, is the most common degenerative of central nervous system. Neuroinflammation currently believed to be a crucial factor in progression AD, while its exact mechanism remains unclear. In this study, we demonstrated that AD transgenic mice exhibited cognitive deficits accompanied by elevated serum and brain inflammation. Treating with natural active ingredient tetrahydroxy stilbene glucoside (TSG) from Chinese herb Polygonum multiflorum...
In this study, we employed nontargeted metabolomics and quantitative analysis to explore the variations in metabolites among white teas from different production areas with varying storage durations. A total of 83 compounds exhibited differential levels between Zhenghe Fuding tea, 89 Jinggu, 75 Jinggu tea. Concerning concentrations flavanols, dimeric catechins, amino acids decreased over time, while N-ethyl-2-pyrrolidone-substituted flavanols (EPSFs), caffeine, adenosine monophosphate (AMP),...
5 T magnetic resonance imaging (MRI)-induced patient discomfort and the associated contributing factors remain unclear. To assess frequency of during MRI examinations analyze that may lead to discomfort, understand potential challenges, improve experience with systems. Prospective study. A total 539 participants, comprising patients healthy volunteers. 5.0 T. Each participant completed a post-MRI examination tolerance questionnaire evaluating overall experience. type was analyzed separately...
ABSTRACT Background Proton density fat fraction (PDFF) and R2* are noninvasive MRI biomarkers for quantifying iron in abdominal organs. While 3.0 T is widely used clinically, 5.0 may offer improved accuracy reliability. With the increasing availability of T, assessing its feasibility utility PDFF organs needed. Purpose To determine agreement liver, pancreas, kidney, paraspinal muscle at 2 different field strengths. Study Type Prospective. Population A total 127 participants, including 60...
The study evaluated whether feeding diosmectite–ZnO composite (DS-ZnO) at 500 mg Zn/kg to early weaned pigs would alleviate the weaning-related intestinal disorders as a substitute for high concentration of ZnO (2250 Zn/kg). an age 21 ± 1 d were allotted four treatments groups follows: (1) control; (2) DS-ZnO, diet; (3) ZnO, 2250 and (4) mixture 2·0 g DS/kg from (equal amount DS in DS-ZnO treatment group). results showed that, compared with control on days 7 14 post-weaning, addition...
Abstract Colorectal carcinoma (CRC) is the one of most common cancers with considerable metastatic potential, explaining need for new drug candidates that inhibit tumor metastasis. The signal transducers and activators transcription 3 (Stat3) signaling pathway has an important role in CRC been validated as a promising anticancer target therapy. In present study, we report our findings on nifuroxazide, antidiarrheal agent identified inhibitor Stat3. Our studies showed nifuroxazide decreased...
Objective:The purpose of this study was to investigate the effects and pharmacological mechanisms icariin, which is main component in traditional Chinese herb Epimedium, on β-amyloid (Aβ) production an amyloid precursor protein (APP) transgenic (Tg) mouse model Alzheimer's disease (AD).Methods: APPV717I Tg mice were randomly divided into a group icariin-treated (30 100 μmol/kg per day) groups.Learning-memory abilities determined by Morris water maze object recognition tests.Aβ contents...
Parkinson's disease (PD) is the second most common neurodegenerative disease. Eigallocatechin-3-gallate (EGCG), major polyphenol in green tea, known to exert a beneficial effect on PD patients. Although some mechanisms were suggested underlie this intervention, it remains unknown if EGCG-mediated protection was achieved by remodeling gut microbiota. In present study, 0.1 mM or 0.5 EGCG administered Drosophila melanogaster with PINK1 (PTEN induced putative kinase 1) mutations, prototype...
Probiotics have been widely used in maintaining intestinal health and one of their benefits is to enhance host antioxidant capacity. However, the involved molecular mechanisms require further investigated. Autophagy a self-protection process response diverse stresses. We hypothesized that probiotics could modulate autophagy alleviate oxidative stress. Sprague-Dawley (SD) rats were orally administered Bacillus SC06 or SC08 daily for 24 days thereafter received an intraperitoneal injection...
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in serine synthesis pathway humans. It converts glycolysis-derived 3-phosphoglycerate 3-phosphopyruvate a co-factor-dependent oxidation reaction. Herein, we report discovery of BI-4916, prodrug co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor BI-4924, which has shown high selectivity against majority other targets. Starting with fragment-based screening, subsequent hit...
Abstract Background Microbial fermentation significantly affects the flavor and efficacy of tea. It is generally believed that fermented tea more effective in lowering lipids, while unfermented can effectively inhibit inflammation. However, there not sufficient evidence to support this claim. To systematically compare hypolipidemic, anti‐inflammatory, anti‐atherosclerotic effects before after microbial fermentation, hyperlipidemic rats inflammatory injury cells were treated with Monascus...
One of the most significant current discussions on Pu-erh tea (ripe tea) is unique aroma aging, but key aroma-presenting substance for aging unclear. This paper explores relationship between and drying method after fermentation. Head space solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) odor activity value (OAV) analyzed samples with different methods temperatures. The results showed that 4-methoxystyrene, 1,2-dihydro-1,1,6-trimethyl-naphthalene, (-)-camphor,...
Serum response factor (SRF) is a ubiquitously expressed transcription that regulates cell-specific functions such as muscle development and breast cancer metastasis. The myocardin-related factors (MRTFs), which are transcriptional coactivators mediating of SRF, also expressed. How MRTFs SRF drive still not fully understood. Here we show LIM domain only 7 (LMO7) regulator plays an important role in cell migration. LMO7 activates by relieving actin-mediated inhibition manner requires,...
Abstract Th17 and regulatory T cells, involved in the pathogenesis of several autoimmune diseases, are new lineages CD4+ helper cells. However, role their imbalance human leukocyte antigen B27-associated acute anterior uveitis has not been elucidated. In our study, percentages Treg molecular markers related factors peripheral blood patients healthy controls were measured by flow cytometry, real-time RT-PCR ELISA. We observed a remarkable increase CD4+IL-17+ cells compared to controls. The...
Abstract Japanese encephalitis (JE) caused by virus (JEV) poses a serious threat to the world’s public health yet without cure. Certain JEV-infected neural cells express subset of previously identified intrinsic antiviral interferon stimulated genes (ISGs), indicating brain retain autonomous immunity. However, whether this happens in composited remains unclear. Human pluripotent stem cell (hPSC)-derived organoids can model disorders human endemic pathogens such as Zika virus, which may...