A5086759035- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Liver physiology and pathology
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- interferon and immune responses
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Heart Rate Variability and Autonomic Control
- DNA Repair Mechanisms
- Gallbladder and Bile Duct Disorders
Sichuan University
2016-2025
Peking University
2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
West China Hospital of Sichuan University
2015-2024
First Affiliated Hospital of Xinjiang Medical University
2023-2024
Xinjiang Medical University
2023-2024
Community Health Center
2024
State Key Laboratory of Biotherapy
2008-2023
Shanxi Medical University
2023
Purpose To determine whether posttransjugular intrahepatic portosystemic shunt (TIPS) placement anticoagulation therapy could benefit patients with cirrhosis and portal vein thrombosis (PVT) from the perspective of a change in patency status clinical outcomes. Materials Methods The study was approved by institutional review board, informed consent obtained each patient. From October 2012 to February 2014, PVT who underwent TIPS were randomly assigned or control group. All followed at 1, 3,...
The optimal treatment for gastric varices (GVs) is a topic that remains open study. This study compared the efficacy and safety of endoscopic cyanoacrylate injection balloon-occluded retrograde transvenous obliteration (BRTO) to prevent rebleeding in patients with cirrhosis GVs after primary hemostasis.Patients history bleeding from gastroesophageal type 2 or isolated 1 were randomized (n = 32) BRTO 32). Primary outcomes variceal all-cause rebleeding. Patient characteristics well balanced...
Abstract Skeletal muscle atrophy (sarcopenia) is a serious complication of liver cirrhosis, and chronic inflammation plays pivotal role in its pathologenesis. However, the detailed mechanism through which injured tissues mediate skeletal inflammatory injury remains elusive. Here, it reported that hepatocytes might secrete mtDNA‐enriched extracellular vesicles (EVs) to trigger by activating cGAS‐STING pathway. Briefly, secreted increased amounts EVs into circulation, are then engulfed...
MicroRNAs (miRNAs) have been demonstrated to modulate cellular processes in the liver. However, role of miRNAs liver fibrosis is poorly understood. Because activation hepatic stellate cells (HSCs) a pivotal event initiation and progression fibrosis, we investigate differential expression activated quiescent rat HSCs by microarray analysis find that miR-214 (miR-214-3p) significantly upregulated during HSC activation. Moreover, robust induction correlated with fibrogenesis carbon...
Abstract Colorectal carcinoma (CRC) is the one of most common cancers with considerable metastatic potential, explaining need for new drug candidates that inhibit tumor metastasis. The signal transducers and activators transcription 3 (Stat3) signaling pathway has an important role in CRC been validated as a promising anticancer target therapy. In present study, we report our findings on nifuroxazide, antidiarrheal agent identified inhibitor Stat3. Our studies showed nifuroxazide decreased...
The activation of hepatic stellate cells (HSCs) participates in liver fibrosis, and emerging evidences indicate that microRNAs (miRNAs) are abnormally expressed during HSC activation. However, the potential roles miRNAs fibrosis still remain elusive. Therefore, this study aimed to investigate role miR-199a-3p its underlying mechanism. We found expression was dramatically upregulated vitro, fibrogenesis CCl4-treated rats, increased patients with cirrhosis. By luciferase assay RT-qPCR, we...
Abstract Background Hypoxia plays an important role in vascular remodeling and directly affects smooth muscle cells (VSMC) functions. Macrophage migration inhibitory factor (MIF) is a well known proinflammatory factor, recent evidence suggests of MIF the progression atherosclerosis restenosis. However, potential link between hypoxia VSMC has not been investigated. The current study was designed to test whether could regulate expression human VSMC. effect modulating on hypoxia-induced...
Background and Aims Genetic predisposition to autoimmune hepatitis (AIH) in adults is associated with possession of human leukocyte antigen (HLA) class I ( A*01 , B*08 ) II DRB1*03 ‐04 ‐ 07 or ‐13 alleles, depending on geographic region. Juvenile liver disease (AILD) comprises AIH‐1, AIH‐2, sclerosing cholangitis (ASC), which are phenotypically different from their adult counterparts. We aimed define the relationship between HLA profile course, severity, outcome juvenile AILD. Approach...
Background Some studies have shown that transjugular intrahepatic portosystemic shunt (TIPS) placement within 72 hours of admission improves survival in patients at high risk who present with acute variceal bleeding. However, the role small-diameter covered TIPS secondary prophylaxis bleeding is still debatable. Purpose To compare efficacy 8-mm and endoscopic ligation (EVL) plus propranolol prevention rebleeding among participants advanced cirrhosis. Materials Methods Between June 2015...
Autoimmune hepatitis (AIH) is a serious liver disease characterized by immune disorders, particularly effector T-cell overactivation. This study aimed to explore the therapeutic effect and underlying mechanism of mesenchymal stem cell-derived extracellular vesicle (MSC-EV) treatment on CD4
Abstract Glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role glucose metabolism insulin secretion. Circulating concentrations of GLP‐1 GIP low can be difficult to assay rodents. These studies utilized novel intestinal lymph fistula model we have established investigate mechanism lipid‐stimulated incretin Peak following an enteral lipid stimulus (Liposyn) were significantly higher than portal...
Abstract Autoimmune hepatitis (AIH) is a necroinflammatory disease associated with interactive cell populations of the innate and adaptive immune systems. The contribution conventional dendritic cells (cDCs) to AIH underlying mechanism remain poorly understood. frequency peripheral mature cDCs increased in patients was positively correlated severity. In experimental autoimmune (EAH), hepatic accumulation observed, along an increase periphery. Sequentially, bone marrow-derived (BMDC) from EAH...
Abstract The RNA‐dependent RNA polymerase (RdRp) is a crucial element in the replication and transcription of viruses. Although RdRps lethal human coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), SARS‐CoV, Middle East (MERS‐CoV) have been extensively studied, molecular mechanism catalytic subunit NSP12, which involved pathogenesis, remains unclear. In this study, biochemical cell biological results demonstrate interactions between SARS‐CoV‐2 NSP12 seven host...
Abstract Background Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC, leading to poorer prognoses than those PBC or alone. The biomarkers associated drug response potential molecular mechanisms in this have not been fully elucidated. Methods Whole-transcriptome sequencing was employed discern differentially expressed (DE) RNAs within good responders (GR) poor (PR) among patients PBC/AIH VS. Subsequent...