The prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for loads in the diagnosis and outcome prediction infection, particularly cases primary lymphoproliferative diseases inflammatory bowel disease (IBD). Receiver operating characteristic (ROC) curves were examined determine suitable thresholds diagnosing predicting its prognosis. 108 patients...

Purpose To determine whether posttransjugular intrahepatic portosystemic shunt (TIPS) placement anticoagulation therapy could benefit patients with cirrhosis and portal vein thrombosis (PVT) from the perspective of a change in patency status clinical outcomes. Materials Methods The study was approved by institutional review board, informed consent obtained each patient. From October 2012 to February 2014, PVT who underwent TIPS were randomly assigned or control group. All followed at 1, 3,...

Epstein-Barr virus (EBV) infection is associated with clinical symptoms, treatment response, need for surgical intervention, and an enhanced likelihood of lymphoma among patients ulcerative colitis (UC). However, existing studies have primarily concentrated on the epidemiological associations between EBV UC, leaving mechanisms by which exacerbates poorly understood. Clinical specimens UC a mouse model dextran sulfate sodium-induced concurrent murine γ-herpesvirus 68 (MHV-68) were utilized to...

Sucralose is a calorie-free high-intensity artificial sweetener that widely used in thousands of foods and beverages all over the world. Although it had been initially regarded as safe inert food additive, its adverse effect on gut microbiota health has drawn more attention evidence accumulates. Studies by us others revealed sucralose exacerbated damage inflammation animal models for inflammatory bowel disease (IBD) including both ulcerative colitis Crohn's disease. Our study demonstrated...

An 83-year-old male presented to our Digestive System Department with a 5-day history of severe gastrointestinal (GI) bleeding and 14-year idiopathic thrombocytopenic purpura (ITP) low platelet levels. Colonoscopy revealed extensive telangiectasias throughout the colon, particularly in transverse ascending segments. Standard treatment proton-pump inhibitors somatostatin proved ineffective. Additionally, conventional therapies such as estrogen thalidomide were contraindicated due comorbidity...

Abstract Inflammatory bowel disease (IBD) is an incurable characterized by remission-relapse cycles throughout its course. Both Crohn's (CD) and ulcerative colitis (UC), the two main forms of IBD, exhibit tendency to develop complications substantial heterogeneity in terms frequency severity relapse, thus posing great challenges clinical management for IBD. Current treatment strategies are effective different ways induction maintenance therapies Recent advances studies genetics,...

Unconjugated bilirubin (UCB) is generally considered toxic but has gained recent prominence for its anti-inflammatory properties. However, the effects of it on interaction between intestinal flora and organisms how influences immune responses remain unresolved.To investigate role UCB in barrier function inflammation mice with dextran-sulfate-sodium-induced colitis.Acute colitis was induced by 3% (w/v) dextran sulfate sodium salt drinking water 6 d followed untreated 2 d. Concurrently, were...

Increasingly studies revealed that dysbiosis of gut microbiota plays a pivotal role in the pathogenesis ulcerative colitis (UC). Fecal transplantation (FMT) has drawn more and attention become an important therapeutic approach. This study aims to examine facts about effective components look into potential mechanisms FMT. Colitis was induced by 3% (w/v) dextran sulfate sodium (DSS) drinking water for 7 days. mice were administered oral gavage with fecal suspension, supernatant, bacteria or...

DSS-induced mouse colitis is caused by the inhibition of SIRT1, leading to β-TrCP1 degradation and Snail1 stabilization, resulting in disruption cell adhesion tight junction, accompanied integrity loss epithelial barrier increased inflammation, which can be alleviated NMN.

Abstract Background Inflammatory bowel disease is a long-standing inflammatory disorder that influences the intestinal tract. The intent of this research to explore whether relative abundance Akkermansia muciniphila related IL6/STAT3 pathway and fundamental molecular mechanisms A. on trinitrobenzene sulfonic acid (TNBS)-induced enteritis mouse model, including expression cytokines proteins in signaling pathway. Methods association between was investigated by using mucosal biopsies fecal...

Background. The purpose of this study was to evaluate the safety and efficacy transjugular intrahepatic portosystemic shunt (TIPS) placement in management portal hypertension noncirrhotic patients with cavernoma. Methods. We conducted a single institution retrospective analysis 15 cavernoma treated TIPS placement. (4 women 11 men) were evaluated via technical success placement, procedural complications, follow-up patency. Results. technically successful out (73.3%). Procedure-related...

Background Transjugular intrahepatic portosystemic shunt (TIPS) creation is an established treatment option to management the complications of portal hypertension. Recent data on long-term outcomes TIPS are scarce. Materials and methods In this single-institution retrospective study, 495 patients underwent with Fluency stent-grafts between December 2011 June 2015 were evaluated. The cumulative rates dysfunction, hepatic encephalopathy (HE), survival, variceal rebleeding determined using...

The purpose of this study is to prospectively evaluate the feasibility and efficacy real-time 3D CT image guidance during transjugular intrahepatic portosystemic shunt (TIPS) creation.Between October 2013 December 2013, a total 20 patients were enrolled in present study. Previously acquired portal venous phase datasets intraoperative registered on dedicated workstation. We accomplished semiautomatic registration for 11 (55%), we performed manual remaining nine patients. selected volume...

Sucralose is one of the most widely used artificial sweeteners, free nutrients and calories. Its approval uses correlate with many worldwide epidemiological changes in inflammatory bowel disease (IBD). Multiple animal studies by us others showed that sucralose exacerbated ileitis SAMP1/YitFc mice 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats. In this study, we further investigated effect on dextran sulfate sodium (DSS)-induced associated mechanisms. Male C57BL/6 received...

Crohn's disease (CD) is a chronic intestinal disorder characterized by refractory gastrointestinal ulcerations. Intestinal tuberculosis (ITB) one common in east Asia. The two diseases share similar clinical manifestations and endoscopic characteristics. Thus, it difficult to establish definite diagnosis of CD, CD concomitant with ITB (CD-ITB), practice. Some enterogeneous microbiotic markers have been applied differentiate ITB, but remains unknown how they work for the three groups patients....

The authors previously demonstrated that unconjugated bilirubin (UCB) may inhibit the activities of various digestive proteases, including trypsin and chymotrypsin. proteases in lower gut are important pathogenesis inflammatory bowel diseases. effects UCB on inflammation levels feces rats with colitis have not yet been revealed. present study investigated effect status chymotrypsin trinitrobenzenesulfonic acid (TNBS)‑induced colitis. data indicated treatment TNBS resulted a marked reduction...

Myocardial contractile dysfunction develops following trauma-hemorrhagic shock (T/HS). We have previously shown that, in a rat fixed pressure model of T/HS (mean arterial 30–35 mmHg for 90 min), mesenteric lymph duct ligation before prevented T/HS-induced myocardial depression. To determine whether directly alters contractility, we examined the functional effects physiologically relevant concentrations collected from rats undergoing trauma-sham (T/SS) or on both isolated cardiac myocytes and...