A5049321787- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Optical Coherence Tomography Applications
- Cell Image Analysis Techniques
- COVID-19 diagnosis using AI
- Drug Solubulity and Delivery Systems
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Cell Adhesion Molecules Research
- Photoacoustic and Ultrasonic Imaging
- Systemic Lupus Erythematosus Research
- Blood properties and coagulation
- Digital Imaging for Blood Diseases
- Digital Holography and Microscopy
- Retinal Imaging and Analysis
- COVID-19 and healthcare impacts
- Image Processing Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Wastewater Treatment and Nitrogen Removal
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Antimicrobial Peptides and Activities
- Flow Measurement and Analysis
The University of Tokyo
2018-2025
Beijing Shijingshan Hospital
2024
Capital Medical University
2024
Dalian Polytechnic University
2024
UConn Health
2024
Taiyuan University of Technology
2024
Shanxi University
2024
Beijing University of Chinese Medicine
2024
Nanjing University of Information Science and Technology
2022-2023
Weifang Medical University
2023
Platelets are anucleate cells in blood whose principal function is to stop bleeding by forming aggregates for hemostatic reactions. In addition their participation physiological hemostasis, platelet also involved pathological thrombosis and play an important role inflammation, atherosclerosis, cancer metastasis. The aggregation of platelets elicited various agonists, but these have long been considered indistinguishable impossible classify. Here we present intelligent method classifying them...
A characteristic clinical feature of COVID-19 is the frequent incidence microvascular thrombosis. In fact, autopsy reports have shown widespread thrombotic microangiopathy characterized by extensive diffuse microthrombi within peripheral capillaries and arterioles in lungs, hearts, other organs, resulting multiorgan failure. However, underlying process COVID-19-associated thrombosis remains elusive due to lack tools statistically examine platelet aggregation (i.e., initiation microthrombus...
Abstract Raman scattering is characterized by the inherently weak inelastic of photons, influenced molecular vibrations or rotations. Recent advances have shifted from traditional electromagnetic enhancement methods to chemically enhanced scattering, offering significant advantages. However, these advancements typically depended on indirect and empirical models. This article introduces a systematic method for rational design engineering chemical scattering. involves identifying promising...
Abstract Sepsis is a life-threatening condition caused by the extreme release of inflammatory mediators into blood in response to infection (e.g., bacterial infection, COVID-19), resulting dysfunction multiple organs. Currently, there no direct treatment for sepsis. Here we report an abiotic hydrogel nanoparticle (HNP) as potential therapeutic agent late-stage The HNP captures and neutralizes all variants histones, major mediator released during highly optimized has high capacity long-term...
Abstract Background Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. The development of novel therapeutic preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between gut microbiome microbial metabolites with behavior, but druggable targets their underlying mechanism action understudied. Results Here, using a drink-in-the-dark mouse model, we...
Intelligent optical time-stretch imaging flow cytometry on a chip is developed for high-throughput, high-accuracy and label-free acute leukemia typing.
Optofluidic time-stretch quantitative phase imaging (OTS-QPI) is a powerful tool as it enables high-throughput (>10,000 cell/s) QPI of single live cells. OTS-QPI based on decoding temporally stretched spectral interferograms that carry the spatial profiles cells flowing microfluidic chip. However, utility troubled by difficulties in retrieval from high-frequency region temporal interferograms, such phase-unwrapping errors, high instrumentation cost, and large data volume. To overcome these...
Imaging flow cytometry is a powerful tool by virtue of its capability for high-throughput cell analysis. The advent high-speed optical imaging methods on microfluidic platform has significantly improved throughput and brought many degrees freedom to instrumentation applications over the last decade, but it also poses predicament chips. Specifically, as increases, speed increases (currently reaching 10 m/s): consequently, increased hydrodynamic pressure chip deforms wall microchannel produces...
Abstract The physical mechanism of the dynamics in laser–material interaction has been an important research area. In addition to theoretical analysis, direct imaging‐based observation ultrafast dynamic processes is approach understand many fundamental issues such as inertial confinement fusion (ICF), laser accelerator construction, and advanced production. this review, principles applications three types commonly used imaging methods are introduced, including pump–probe, X‐ray diagnosis,...
Optofluidic time-stretch quantitative phase imaging (OTS-QPI) is a potent tool for biomedical applications as it enables high-throughput QPI of numerous cells large-scale single-cell analysis in label-free manner. However, there are few critical limitations that hinder OTS-QPI from being widely applied to diverse applications, such its costly instrumentation and inherent phase-unwrapping errors. Here, overcome the limitations, we present QPI-free method generates "virtual" images their...
Goal: As a multiphysics imaging approach, magnetoacoustic tomography with magnetic induction (MAT-MI) works on the physical mechanism of excitation, acoustic vibration, and transmission. Methods : Based theoretical analysis source numerical studies are conducted to simulate pathological changes tissues for single-layer cylindrical conductivity gradual-varying model estimate strengths sources inside model. Results: The results suggest that inner is generated by product curl induced electric...
Abstract There is a global concern about the safety of COVID‐19 vaccines associated with platelet function. However, their long‐term effects on overall activity remain poorly understood. Here we address this problem by image‐based single‐cell profiling and temporal monitoring circulating aggregates in blood healthy human subjects, before after they received multiple Pfizer‐BioNTech (BNT162b2) vaccine doses over time span nearly 1 year. Results show no significant or persisting aggregation...
Microvascular thrombosis is a typical symptom of COVID-19 and shows similarities to thrombosis. Using microfluidic imaging flow cytometer, we measured the blood 181 samples 101 non-COVID-19 samples, resulting in total 6.3 million bright-field images. We trained convolutional neural network distinguish single platelets, platelet aggregates, white cells performed classical image analysis for each subpopulation individually. Based on derived single-cell features population, machine learning...