A5054684867- Gut microbiota and health
- Tryptophan and brain disorders
- Diet and metabolism studies
- Pediatric health and respiratory diseases
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- GABA and Rice Research
- Bacteriophages and microbial interactions
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Ferroptosis and cancer prognosis
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Gestational Diabetes Research and Management
- Oral microbiology and periodontitis research
- Cleft Lip and Palate Research
- COVID-19 Impact on Reproduction
- Dermatology and Skin Diseases
- Pharmacological Effects of Medicinal Plants
- Inflammasome and immune disorders
UConn Health
2021-2025
Universidad Cristiana Autónoma de Nicaragua
2022-2024
Development and severity of alcohol use disorder (AUD) has been linked to variations in gut microbiota their associated metabolites both animal human studies. However, the involvement microbiome consumption individuals with AUD undergoing treatment remains unclear. To address this, stool samples (n = 32) were collected at screening (baseline) trial completion from a double-blind, placebo-controlled zonisamide AUD. Alcohol was measured baseline endpoint 16-week period. Fecal analyzed via 16 S...
Abstract Background Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. The development of novel therapeutic preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between gut microbiome microbial metabolites with behavior, but druggable targets their underlying mechanism action understudied. Results Here, using a drink-in-the-dark mouse model, we...
The powerful immune responses elicited by the mRNA vaccines targeting SARS-CoV-2 Spike protein contribute to their high efficacy. Yet, efficacy can vary greatly between individuals. For not based on mRNA, cumulative evidence suggests that differences in composition of gut microbiome, which impact vaccine immunogenicity, are some factors variations However, it is unclear if microbiome impacts novel mode immunogenicity vaccines. We conducted a prospective longitudinal cohort study individuals...
Preeclampsia (PE) is a leading cause of morbidity and mortality in pregnancy with elusive etiology. Patients PE are thought to be associated higher rate periodontal diseases (PDs) changes oral bacteria targeted PCR techniques. However, few studies have investigated the associations between microbiome dysbiosis secondarily disseminated microbes placenta simultaneously patients PE. The association detected systemic inflammation also unclear. We enrolled 54 pregnant without PD, profiled...
Development and severity of alcohol use disorder (AUD) has been linked to variations in gut microbiota their associated metabolites both animal human studies. However, the involvement microbiome consumption individuals with AUD undergoing treatment remains unclear. To address this, stool samples (n=48) were collected at screening (baseline) trial completion from a single site multi-site double-blind, placebo-controlled Zonisamide AUD. Alcohol consumption, gamma-glutamyl transferase (GGT),...
<title>Abstract</title> Background Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. Development of novel therapeutic preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between gut microbiome microbial metabolites with behavior, but druggable targets their underlying mechanism action understudied. Results Here, using a drink-in-the-dark mouse...
Asthma is associated with significant morbidity. The gut microbiome has been shown to effect asthma development and exacerbation. In this study, we tested an oral supplement containing Boswellia serrata (Indian frankincense) tree resin on allergic pulmonary inflammation microbiome. An OVA based airway model was used mice were orally gavaged 100 mg/kg of as a supplementation throughout sensitization challenge. Treated showed weight loss, lower total lung leukocytes, eosinophil Th2 cytokines,...
Abstract Multiple sclerosis (MS) is an autoimmune condition associated with dysbiosis in the bacterial element of microbiome, yet limited information exists regarding virome. In this study, we examined virome 20 relapsing-remitting MS (RRMS) patients and 22 healthy controls (HC). We extracted virus-like particles (VLP) genomic DNA through sequential filtration, followed by deep metagenomic sequencing approaches without multiple displacement amplification (MDA). found significantly lower...
Objective: Preeclampsia (PE) is a leading cause of morbidity and mortality in pregnancy. This observational study aims to determine associations between oral placental microbiome women with without preeclampsia periodontal disease (PD) evaluate systemic immune responses patients PE PD. Population: Fifty-four pregnant PD were recruited. The profiles both subgingival region placenta characterized by V4 16S rRNA gene sequencing. Systemic inflammation markers tumor necrosis factor-alpha (TNF-α),...