A5015988126- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Optical Coherence Tomography Applications
- COVID-19 and healthcare impacts
- Gold and Silver Nanoparticles Synthesis and Applications
- Long-Term Effects of COVID-19
- Photoacoustic and Ultrasonic Imaging
- Cell Image Analysis Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microfluidic and Bio-sensing Technologies
- Luminescence and Fluorescent Materials
- Radiation Detection and Scintillator Technologies
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Advanced Nanomaterials in Catalysis
- Venous Thromboembolism Diagnosis and Management
- Nanocluster Synthesis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Conducting polymers and applications
- Nanofabrication and Lithography Techniques
- Luminescence Properties of Advanced Materials
- Coronary Interventions and Diagnostics
- Lanthanide and Transition Metal Complexes
The University of Tokyo
2021-2025
University of Virginia
2021
Tianjin University
2021
A characteristic clinical feature of COVID-19 is the frequent incidence microvascular thrombosis. In fact, autopsy reports have shown widespread thrombotic microangiopathy characterized by extensive diffuse microthrombi within peripheral capillaries and arterioles in lungs, hearts, other organs, resulting multiorgan failure. However, underlying process COVID-19-associated thrombosis remains elusive due to lack tools statistically examine platelet aggregation (i.e., initiation microthrombus...
Abstract Raman scattering is characterized by the inherently weak inelastic of photons, influenced molecular vibrations or rotations. Recent advances have shifted from traditional electromagnetic enhancement methods to chemically enhanced scattering, offering significant advantages. However, these advancements typically depended on indirect and empirical models. This article introduces a systematic method for rational design engineering chemical scattering. involves identifying promising...
Circulating tumor cells (CTCs) are precursors to cancer metastasis. In blood circulation, they take various forms such as single CTCs, CTC clusters, and CTC-leukocyte all of which have unique characteristics in terms physiological function been a subject extensive research the last several years. Unfortunately, conventional methods limited accurately analysing highly heterogeneous nature CTCs. Here we present an effective strategy for simultaneously CTCs by virtual-freezing fluorescence...
Intelligent optical time-stretch imaging flow cytometry on a chip is developed for high-throughput, high-accuracy and label-free acute leukemia typing.
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for label-free chemical analysis. The emergence of nonmetallic materials as SERS substrates, offering signal enhancements, presents an exciting direction achieving reproducible and biocompatible SERS, challenge with traditional metallic substrates. Despite the potential, realm particularly nanoparticles, remains largely untapped. Here, we present defect-engineered coordination compounds (DECCs) based on Prussian blue analogues...
Vascular stenosis caused by atherosclerosis instigates activation and aggregation of platelets, eventually resulting in thrombus formation. Although antiplatelet drugs are commonly used to inhibit platelet aggregation, they unfortunately cannot prevent recurrent thrombotic events patients with atherosclerosis. This is partially due the limited understanding efficacy complex hemodynamic environment vascular stenosis. Conventional methods for evaluating under either fail simulate characterized...
Surface-enhanced Raman spectroscopy (SERS) has made significant progress in recent decades, primarily driven by the principles of plasmon on metal surfaces. In contrast, SERS non-metal substrates is based chemical mechanism involving charge transfer (CT) processes within irradiated molecules and resonance effect. This plasmon-free proves highly suitable for detecting biomedical samples, as it suppresses photo-thermal conversion associated with plasmon. this study, we developed using...
ABSTRACT A characteristic clinical feature of COVID-19 is the frequent incidence microvascular thrombosis. In fact, autopsy reports have shown widespread thrombotic microangiopathy characterized by extensive diffuse microthrombi within peripheral capillaries and arterioles in lungs, hearts, other organs, resulting multiorgan failure. However, underlying process COVID-19-associated thrombosis remains elusive due to lack tools statistically examine platelet aggregation (i.e., initiation...
Vascular stenosis caused by atherosclerosis can lead to platelet activation and aggregation in thrombosis. However, the efficacy of antiplatelet drugs under is not well understood due lack analytical tools. Here we demonstrate a new method combining optofluidic time-stretch quantitative phase microscopy 3D chip enable highspeed, high-resolution, label-free imaging circulating aggregates atherogenic flow conditions. Interestingly, our findings indicate that proposed high-speed on-chip...
Vascular stenosis is a pathological hallmark of atherosclerosis, but its transient process not well understood due to the lack analytical tools study it. Here we report spatiotemporally resolved observation shear-induced platelet aggregation by combining microfluidic on-chip model and optofluidic time-stretch microscopy. Our results indicate synergistic effect agonists on activation aggregation. Particularly, an agonist, thrombin receptor activator peptide 6, causes preferential enhancement...
Abstract A characteristic clinical feature of COVID-19 is the frequent occurrence thrombotic events. Furthermore, many cases multiorgan failure are in nature. Since outbreak COVID-19, D-dimer testing has been used extensively to evaluate COVID-19-associated thrombosis, but does not provide a complete view disease because it probes blood coagulation, platelet activity. Due this limitation, fails account for events which occur despite low levels, such as sudden stroke young patients and...