A5100318008- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Tissue Engineering and Regenerative Medicine
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Retinal Diseases and Treatments
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Advanced Glycation End Products research
- Mosquito-borne diseases and control
- Pluripotent Stem Cells Research
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Ocular Disorders and Treatments
- Virus-based gene therapy research
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- dental development and anomalies
- Developmental Biology and Gene Regulation
- Hedgehog Signaling Pathway Studies
- Monoclonal and Polyclonal Antibodies Research
Xiamen University
2016-2025
People's Liberation Army 401 Hospital
2025
Chinese People's Liberation Army
2022-2025
Henan Provincial People's Hospital
2025
Zhengzhou University
2025
Shanghai Mental Health Center
2025
Shanghai Jiao Tong University
2013-2025
National Neuroscience Institute
2025
Singapore General Hospital
2025
Duke-NUS Medical School
2025
Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It characterized by loss of tear film homeostasis and accompanied symptoms that may potentially result in damage to surface even vision loss. Unmodifiable risk factors for DED mainly include aging, hormonal changes, lifestyle issues such as reduced sleep duration, increased screen exposure, smoking, ethanol consumption. As its prevalence continues rise, has garnered considerable attention, prompting exploration...
Artemisinins, derived from the wormwood herb Artemisia annua, are most potent antimalarial drugs currently available. Despite extensive research, exact mode of action artemisinins has not been established. Here we use yeast, Saccharamyces cerevisiae, to probe core working mechanism this class agents. We demonstrate that artemisinin's inhibitory effect is mediated by disrupting normal function mitochondria through depolarizing their membrane potential. Moreover, in a genetic study, identify...
purpose. To determine the prevalence of Demodex in eyelashes with cylindrical dandruff (CD). methods. A modified sampling and counting method was applied to 55 clinical cases. Patients were divided group (n = 20) diffuse CD, B 12) sporadic C 23) clean lashes or greasy scales, which latter into subgroup C1 15) without lid hygiene C2 8) using daily for past year. Each patient underwent a routine complete eye examination counts Demodex. results. found all patients 32) significantly higher than...
The tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging. In addition, accumulation observed hepatocytes individuals with fibrotic liver diseases, but significance this is not known. Herein, we have mechanistically linked activation to fibrosis. Hepatocyte-specific deletion mice gene encoding Mdm2, a protein that promotes degradation, led hepatocyte synthesis connective tissue growth factor...
Interleukin-1 (IL-1) is an inflammatory cytokine that has been linked to muscle catabolism, a process regulated by muscle-specific E3 proteins of the ubiquitin-proteasome pathway. To address cellular mechanism, we tested hypothesis IL-1 induces myofibrillar protein loss acting directly on increase expression two critical proteins, atrogin1/muscle atrophy F-box (MAFbx) and RING-finger 1 (MuRF1). Experiments were conducted using mature C2C12 myotubes eliminate systemic effects avoid paracrine...
A new polymerizable imidazolium salt monomer, 1-(4-vinylbenzyl)-3-methyl-imidazolium chloride ([VBMI]Cl), has been readily synthesized by reaction of 4-vinylbenzyl with 1-methylimidazole. Novel anion exchange membranes (AEMs) based on the copolymers [VBMI]Cl and styrene have prepared characterized. Excellent thermostability is observed through thermo-gravimetric analysis (TGA) curves. Water uptake ion capacity (IEC) OH− form AEMs range from 26.1% to 61.9% 0.95 1.45 mmol g−1, respectively....
We report the rational design of coordination-driven self-assembly metal-organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination-based nano-formulations capable loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging-guided combination photo/gene therapy strategy. showed enhanced theranostic capability zinc(II)-dipicolylamine-assisted assembly ICG, as well simultaneous targeted gene delivery in an...
Purpose: Cell death in neurodegeneration occurs at the convergence of diverse metabolic pathways. In retina, a common underlying mechanism involves mitochondrial dysfunction since photoreceptor homeostasis and survival are highly susceptible to altered aerobic energy metabolism. We sought develop an assay directly measure oxygen consumption intact retina with goal identifying alterations respiration during degeneration. Methods: Circular punches freshly isolated mouse adjacent optic nerve...
Mesenchymal stem cells (MSCs) are well known having beneficial effects on intracerebral hemorrhage (ICH) in previous studies. The therapeutic mechanisms mainly to investigate proliferation, differentiation, and immunomodulation. However, few studies have used MSCs treat blood–brain barrier (BBB) leakage after ICH. influence of the BBB its related were investigated when transplanted into rat ICH model this study. Adult male Sprague–Dawley (SD) rats randomly divided sham-operated group,...