A5102025058- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Drug-Induced Adverse Reactions
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Medicine and Dermatology Studies History
- Biomedical Ethics and Regulation
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- Reservoir Engineering and Simulation Methods
- Axon Guidance and Neuronal Signaling
- Connective Tissue Growth Factor Research
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Cell Adhesion Molecules Research
- Nail Diseases and Treatments
- Cancer, Lipids, and Metabolism
Air Force Medical University
2011-2025
Xijing Hospital
2009-2025
University of Colorado Anschutz Medical Campus
2020
University of Colorado Denver
2020
B 1 cells are evolutionarily conserved innate‐like that share many features with macrophages. It has also been established have a close developmental relationship However, whether able to act as professional phagocytic is not clear. In this study, we report mouse peritoneal cavity ( P er C ) demonstrate in vivo and vitro activities for S taphylococcus aureus, E scherichia coli , polystyrene fluorescent microspheres. Approximately 5% of cells, mainly b showed activity. Ingested microbes were...
Circulating exosomal miR-375-3p promotes keratinocyte apoptosis via XIAP repression in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Chronic cutaneous mucormycosis is a rare condition distinct from the acute form, characterized by prolonged, indolent course and varied clinical presentations. This study presents 5-year experience tertiary dermato-mycology clinic, identifying six cases, majority of whom were immunocompetent, with trauma history reported in four patients. The median duration symptom onset to diagnosis was 60 months. primary pathogens identified Rhizopus arrhizus, Mucor variabilis, Lichtheimia ramosa....
Impaired function of filaggrin (FLG) is a major predisposing factor for atopic dermatitis (AD). Several studies on FLG-deficient (Flg-/- ) mice have indicated an essential role FLG in the skin barrier and development AD, but none described characteristics Flg-/- with calcipotriol (CPT)-induced dermatitis, which restricts comprehensive understanding functions FLG. The present study sought to generate applied CPT produce AD-like vivo analysis functions. was establish mouse model. lesion...
Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, specific role different subsets DCs has not well defined. This study aimed to investigate contributions Langerhans (LCs), resident dermal Langerin+ (r-Langerin+ dDCs), and newly infiltrated inflammatory (i-Langerin+ dDCs) an AD mouse model induced by topical application MC903. The result showed that depletion i-Langerin+ dDCs DTR mice after multiple diphtheria toxin (DT) injection...
Abstract The conglomerate reservoir with a very low porosity and permeability is one of the most important reservoirs in Northwest China. pay zones are difficult to be identified which more than 200 meters thick, because there no any clear positive response open-hole logs. It challenging evaluate this kind tight using traditional methods. Identifying evaluating fracture fractured were objective case study. high-resolution resistivity image logs widely acquired on key wells research area....
Natural autoreactive B cells are important mediators of autoimmune diseases. Receptor editing is known to play an role in both central and peripheral cell tolerance. However, the allelic inclusion development natural not clear. Previously, we generated μ chain (TgVH3B4I) μ/κ chains (TgVH/L3B4) transgenic mice using transgene derived from 3B4 hybridoma, which produce poly-reactive autoantibodies. In this study, demonstrate that a considerable population edited their receptors (BCRs) via light...
The incidence of skin disease is high, and outpatients have high demand for doctor-patient communication. However, the education communication undergraduate student very poor almost absent dermatology. For stage graduate study dermatology, it important to learn grasp dermatology knowledge, develop fundamental skill as a dermatologist, includ-ing In view problems such short time, incomplete communication, low specialization, we developed norms students, help students majoring in realize...
Objective To compare the cellular and serum expression levels of granulysin among patients with different types drug eruption.Methods Blood samples were collected from 7 toxic epidermal necrolysis (TEN),5 acute Stevens-Johnson syndrome (SJS),8 erythema multiforme,8 exanthematic eruption,and 11 healthy controls.Flow cytometry enzyme-linked immunosorbent assay (ELISA) performed to quantify protein in peripheral blood T cells sera these subjects,respectively.Data processed by SPSS17.0...
It was accepted in the past that only these cells such as macrophage, histoleucocyte, granular cell and dendritic are phagocytes, while B lymphocyte has no ability to phagocytize, although it can generate specific immune globulin for antigen binding. However recent studies indicate of osteichthyes (trout) amphibia (xenopus laevis) phagocytize particulate antigen, first time re-vealed relatively archaic too. Numerous reveal B-1 mammalian probably phagocytize. Key words: B lymphocyte; ...
Abstract It has long been recognized that B cells lack phagocytic capabilities. Until recently, from teleost fish were shown to have potent abilities for particle antigens; however, whether mammalian are able accomplish phagocytosis is still not clear. Here we demonstrated mouse peritoneal cavity (PerC) B-1 cells, which thought be the counterpart of blood had in vivo and vitro activities Staphylococcus aureus polystyrene fluorescent microspheres. Ingestion particles by led activation...