A5060423640- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Gene expression and cancer classification
- RNA modifications and cancer
- Biological Activity of Diterpenoids and Biflavonoids
- Supercapacitor Materials and Fabrication
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Bioinformatics and Genomic Networks
- Advanced battery technologies research
- Alzheimer's disease research and treatments
- Cancer Mechanisms and Therapy
- Food Drying and Modeling
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Cancer-related Molecular Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Genomics and Diagnostics
- Food composition and properties
- Circular RNAs in diseases
- Laser Applications in Dentistry and Medicine
Jackson Laboratory
2018-2025
Hefei University
2021-2025
Shanghai Jiao Tong University
2014-2024
Shanghai First People's Hospital
2014-2024
Nanjing Medical University
2022-2023
Second Affiliated Hospital of Nanjing Medical University
2023
Jiangsu Province Hospital
2022-2023
Soochow University
2018-2023
First Affiliated Hospital of Soochow University
2018-2023
Shandong University
2020-2022
Maintenance of protein homeostasis degrades with age, contributing to aging-related decline and disease. Previous studies have primarily surveyed transcriptional aging changes. To define the effects age directly at level, we perform discovery-based proteomics in 10 tissues from 20 C57BL/6J mice, representing both sexes adult late midlife ages (8 18 months). Consistent previous studies, age-related changes abundance often no corresponding change. Aging results increases immune proteins across...
How prostate cancer is initiated remains a topic of debate. In an effort to establish human model carcinogenesis, we adapted premalignant EPT2-D5 cells protein-free medium generate numerous tight spheres (D5HS) in monolayer culture. contrast cells, the newly generated D5HS efficiently formed large subcutaneous tumors and subsequent metastases vivo, showing tumorigenicity spheres. A striking production interleukin (IL)-6 mRNA protein was found cells. The essential roles IL-6 downstream STAT3...
Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated kinase (PAK), hypoxia or epithelial-mesenchymal transition (EMT) contributed the VM potential. However, details underlying these biological behaviors have not been completely elucidated.Kaplan-Meier analysis was conducted predict relationship with Inducible factor (HIF-1α), EMT related...
Introduction: Since intrinsic ocular barrier limits the intraocular penetration of therapeutic protein through eye drops, repeated intravitreal injections anti-vascular endothelial growth factor (anti-VEGF) agents are standard therapy for neovascular age-related macular degeneration (nAMD), which highly invasive and may cause particular complications, leading to poor patient compliance. Methods: Using Penetratin (Pen) as enhancer hyaluronic acid (HA) retina-targeting ligand, a dual-modified...
ABSTRACT: BACKGROUND: With DNA microarray data, selecting a compact subset of discriminative genes from thousands is critical step for accurate classification phenotypes for, e.g., disease diagnosis. Several widely used gene selection methods often select top-ranked according to their individual power in classifying samples into distinct categories, without considering correlations among genes. A limitation these that they may result sets with some redundancy and yield an unnecessary large...
Non-alcoholic fatty liver disease (NAFLD) is a prevalent associated with lipotoxicity, lipid peroxidation, oxidative stress, and inflammation. Nuciferine, an active ingredient extracted from the natural lotus leaf, has been reported to be effective for prevention treatment of NAFLD. Per-Arnt-Sim kinase (PASK) nutrient responsive protein that regulates glucose metabolism, mitochondrial respiration, gene expression. The aim present study was investigate protective effect nuciferine against...
Myocarditis has emerged as an immune-related adverse event of immune checkpoint inhibitor (ICI) cancer therapy associated with significant mortality. To ensure patients continue to safely benefit from life-saving therapy, understanding fundamental immunological phenomena underlying ICI myocarditis is essential. We recently developed the NOD-cMHCI/II-/-.DQ8 mouse model that spontaneously develops lower mortality than observed in previous HLA-DQ8 NOD strains. Our strain was rendered murine MHC...
Bacopa monnieri (L.) WETTST. is extensively used in traditional Indian medicine as a nerve tonic. The neuropharmacological properties of bacopaside I, an important component from B. monnieri, have not been studied so far. present study investigated the effects and possible mechanisms I rat model transient focal ischemia induced by middle cerebral artery occlusion (MCAO).Adult male Sprague-Dawley rats were divided into five groups: sham-operated group, three I-treated groups (3, 10 30 mg/kg)...
Hepatocellular carcinoma (HCC) is the sixth most common malignancy with limited treatment options. Hinokiflavone (HF), a natural biflavonoid, has shown to inhibit proliferation of melanoma, whereas its antitumour effect against HCC and underlying mechanisms remain elusive. Here, we aimed at evaluating in both vitro vivo. Cell counting kit 8, colony formation assay, PI/RNase staining Western blotting revealed that HF inhibited cells via G0/G1 cell cycle arrest p21/p53 up-regulation. DAPI...
Patients with hepatocellular carcinoma (HCC) are vulnerable to drug resistance. Although resistance has been taken much attention HCC therapy, little is known of regorafenib and (RR). This study aimed determine the pattern role RhoA in RR. Two regorafenib-resistant cell lines were constructed based on Huh7 Hep3B lines. In vitro vivo assays conducted expression, activity Hippo signaling pathway cancer stem (CSC) traits. The data showed that was highly expressed, hypoactivated CSC traits more...
Ras homolog family member A (RhoA) and Rho-associated coiled coil-containing protein kinases 1 2 (ROCK1 2) are key regulators of focal adhesion, actomyosin contraction cell motility. RhoA/ROCK signaling has emerged as an attractive target for the development new cancer therapeutics. Whether is involved in regulating formation tumor vasculogenic mimicry (VM) largely unknown. To confirm this hypothesis, we performed vitro experiments using hepatocellular carcinoma (HCC) lines. Firstly,...
The biological effects of different wavelengths light emitting diode (LED) tend to vary from each other. Research into use photobiomodulation for treatment skin wounds and the underlying mechanisms has been largely lacking. We explored histopathological basis therapeutic effect relation between duration exposure LED in a Japanese big-ear white rabbit skin-wound model. Skin wound model was established 16 rabbits (three per rabbit: one served as control, other two were irradiated by red blue...
Liver cancer is the fifth most commonly diagnosed malignancy, of which hepatocellular carcinoma (HCC) represents dominating histological subtype. Antiangiogenic therapy aimed at vascular endothelial growth factor (VEGF) has shown promising but deficient clinical prospects on account vasculogenic mimicry, a highly patterned channel distinguished from endothelium-dependent blood vessel, may function as supply networks occurring in aggressive tumors including HCC. In this study, we used new...
Background. Antioxidant enzyme status changes in experimental models of chronic renal disease with glomerulosclerosis. Most the studies are performed rats. We now investigate whether a mouse model more rapid development glomerulosclerosis is suitable for study radical‐associated disease.
Across the population, individuals exhibit a wide variation of susceptibility or resilience to developing Alzheimer's disease (AD). Identifying specific factors that promote would provide insight into mechanisms and nominate potential targets for therapeutic intervention. Here, we use transcriptome profiling identify gene networks present in pre-symptomatic AD mouse brain relating neuroinflammation, vasculature, extracellular matrix organization, synaptic signaling predict cognitive...
This research evaluated the effect of fermentation with Lactobacillus plantarum 11122, casei 23184, and lactis 1011 on structure, pasting, in vitro digestion properties glutinous rice starch varying TN HY genotype, respectively. The results showed that decreased weight-average molecular weight increased radius gyration. short chain was by degrading medium (B2, DP 24−35) amorphous starch, which directly led to increase branching degree rearrangement chain. LAB increases short-range ordered...