A5101437109- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Analysis
- Mitochondrial Function and Pathology
- Plant-derived Lignans Synthesis and Bioactivity
- Biological Activity of Diterpenoids and Biflavonoids
- Advanced biosensing and bioanalysis techniques
- Phytochemistry and Biological Activities
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis of Organic Compounds
- Stroke Rehabilitation and Recovery
- Pharmacological Effects of Natural Compounds
- Virus-based gene therapy research
- Chromatography in Natural Products
- Bioactive Compounds and Antitumor Agents
- Statistical Methods in Clinical Trials
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Statistical Methods and Bayesian Inference
- Neurological Disorders and Treatments
- Pain Management and Treatment
- Natural Compound Pharmacology Studies
117th Hospital of People's Liberation Army
2025
Hebei Medical University
2017-2024
First Affiliated Hospital of Hebei Medical University
2019-2024
Capital Medical University
2024
Hebei North University
2017-2021
Chengdu University of Traditional Chinese Medicine
2014-2021
Beijing Radiation Center
2021
Second Military Medical University
2011-2018
Lanzhou Army General Hospital
2018
Air Force Medical University
2012-2016
Evidence suggests Ginsenoside Rd (GSRd), a biologically active extract from the medical plant Panax Ginseng, exerts antioxidant effect, decreasing reactive oxygen species (ROS) formation. Current study determined effect of GSRd on myocardial ischemia/reperfusion (MI/R) injury (a pathological condition where ROS production is significantly increased) and investigated underlying mechanisms. The current utilized an in vivo rat model MI/R vitro neonatal cardiomyocyte (NRC) simulated (SI/R)...
Oxidative stress is considered the major cause of tissue injury after cerebral ischemia. The nuclear factor erythroid 2-related 2 (Nrf2) pathway one most important defensive mechanisms against oxidative stresses and has been confirmed as a target for stroke treatment. Thus, we desired to find new Nrf2 activators test their neuronal protective activity both in vivo vitro.The herb-derived compound, Britanin, potent inducer system. Britanin can induce expression enzymes reverse oxygen-glucose...
Abstract Background Injection of naked DNA has been viewed as a safer alternative to current gene delivery systems; however, the rate clearance from circulation constant barrier in developing these methods. Naked after intravenous (i.v.) injection will be taken up by liver and depredated serum nucleases. Materials methods Our study examines mechanisms involved each compartment, blood liver, an vivo mouse model. Confocal microscopy transmission electron were employed identify type cells...
As a therapeutic target for antitumor necrosis factor (TNF)-α interventions, UbcH5c is one of the key ubiquitin-conjugating enzymes catalyzing ubiquitination during TNF-α-triggered nuclear kappa B (NF-κB) activation. In present study, three series analogues were designed and synthesized from α-santonin, their inhibitory activities screened by Western blotting NF-κB luciferase assay. Further BIAcore, in-gel fluorescence imaging, immunoprecipitation assays demonstrated that compound 6d...
Red pigment (RP) was extracted from the peels of Zanthoxylum bungeanum Maxim (PZB) by ultrasonic-assisted extraction (UAE) in this work. Box⁻Behnken design⁻response surface methodology (BBD-RSM) employed to research efficiency RP extraction. Based on optimization RSM, results showed that optimal conditions were as follows: liquid⁻solid ratio 31 mL/g, time 41 min, and temperature 27 °C, under these conditions, actual absorbance value 0.615 ± 0.13%, highly agreeing with predicted model....
Bombyx batryticatus is a known traditional Chinese medicine (TCM) utilized to treat convulsions, epilepsy, cough, asthma, headaches, and purpura in China for thousands of years. This study aimed at investigating the antiepileptic effects protein-rich extracts from (BBPs) on seizure mice exploring protective BBPs against H 2 O -induced oxidative stress PC12 cells their underlying mechanisms. Maximal electroshock-induced (MES) pentylenetetrazole- (PTZ-) induced histological analysis were...
Seven new diterpenoids lanceolatins A–G (<bold>1–7</bold>)were isolated from the branches and leaves of Cephalotaxus lanceolata, <italic>in vitro</italic> anti-inflammatory antitumor activities were evaluated.
Background/Aims: FOXC2 has been reported to play a role in tumor progression, but the correlations of with cisplatin (CDDP) resistance ovarian cancer cells are still unclear. The purpose present study is investigate roles CDDP and its possible mechanisms. Methods: Quantitative real-time PCR (qRT-PCR) was performed detect expression mRNA CDDP-resistant or sensitive tissues cell lines (SKOV3/CDDP SKOV3). Gain- loss-of-function assays were analyze effects knockdown overexpression on vitro vivo...
Background/Aims: Forkhead Box Protein C2 (FOXC2) has been reported to be overexpressed in a variety of human cancers. However, it is unclear whether FOXC2 regulates epithelial-mesenchymal transition (EMT) CDDP-resistant ovarian cancer cells. The aim this study investigate the effects on EMT and invasive characteristics cells underlying molecular mechanism. Methods: MTT, Western blot, scratch wound healing, matrigel transwell invasion, attachment detachment assays were performed detect half...
Insulin protects cardiomyocytes from myocardial ischemia/reperfusion (MI/R) injury through activating Akt. However, phosphatase PHLPP-1 (PH domain leucine-rich repeat protein phosphatase-1) dephosphorylates and inactivates The balanced competitive interaction of insulin has not been directly examined. In this study, we have identified the effect mutual inhibition signaling on cardioprotective efficiency Akt in aged heart. Young (3 months) (20 Sprague Dawley (SD) rats were subjected to MI/Rin...
<title>Abstract</title> <bold>Background</bold> This study aimed to evaluate the impact of optimized diagnostic protocols on pathogen detection rates in abscess specimens. <bold>Methods </bold>Our retrospective analyzed 1,297 specimens collected between 2018 and 2024 using an enhanced protocol combining four key methodologies: routine aerobic/anaerobic culture, Gram-stain microscopy, acid-fast bacilli staining, blood culture bottle enrichment techniques. <bold>Results</bold> The...
In this study, a novel lipid vector has been developed for targeted delivery of oligodeoxynucleotides (ODN) to tumors that overexpress folate receptor. This is based on method by Semple et al. (1), which utilizes an ionizable aminolipid (1,2-dioleoyl-3-(dimethylammonio)propane, DODAP) and ethanol-containing buffer system encapsulating large quantities polyanionic ODN in vesicles. Folate incorporated into the vesicles via distearoylphosphatidylethanolamine−poly(ethylene glycol) (DSPE−PEG)...
Abstract Targeted inhibition of protein kinase C (PKC) inhibits hepatocellular carcinoma (HCC) proliferation and metastasis. We previously reported the cytotoxicity a series synthetic phenyl-substituted polyoxygenated xanthone derivatives against human HCC. In current study, most potent natural product, isojacareubin (ISJ), was synthesized its cellular-level antihepatoma activities were evaluated. ISJ significantly inhibited cell highly selective for HCC cells in comparison to nonmalignant...
Cynandione A, an acetophenone from the roots of Cynanchum auriculatum and other species in genus attenuates neurotoxicity a variety neurotoxic agents such as l-glutamate vitro. In this study, we sought to further characterize neuroprotective effects cynandione A acetophenones C. pheochromocytoma tumor cell line PC12 investigate whether protected against ischemic injuries rats with experimentally induced cerebral ischemia. Viability assays using...
Bupivacaine induces central neurotoxicity at lower blood concentrations than cardiovascular toxicity. However, sensitivity to bupivacaine is poorly understood. The toxicity mechanism might be related glutamate-induced excitotoxicity in hippocampal cells.The intracellular free Ca concentration ([Ca]i), mitochondrial membrane potential, and reactive oxygen species generation were measured by fluorescence two-photon laser scanning microscopy fetal rat neurons astrocytes.In astrocyte/neuron...