A5102408347- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antifungal resistance and susceptibility
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Fungal Infections and Studies
- Natural product bioactivities and synthesis
- Click Chemistry and Applications
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Sesquiterpenes and Asteraceae Studies
- Catalytic Alkyne Reactions
- Phytochemistry and Biological Activities
- Chemical synthesis and alkaloids
- Fungal Plant Pathogen Control
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Bioactive Compounds and Antitumor Agents
- Lanthanide and Transition Metal Complexes
- Marine Sponges and Natural Products
- Chemical Synthesis and Analysis
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Synthesis of Organic Compounds
- Cyclopropane Reaction Mechanisms
Shanghai Institute of Pharmaceutical Industry
2015-2025
Chinese PLA General Hospital
2023-2025
Chinese People's Liberation Army
2025
China Institute of Water Resources and Hydropower Research
2022
Nanchang University
2021
Yunnan Agricultural University
2021
Second Military Medical University
2006-2015
Heilongjiang University
2015
Harbin University
2015
Shanghai Jiao Tong University
2013-2015
Tumor-associated neutrophils (TANs) play a critical role in the progression and prognosis of triple-negative breast cancer (TNBC), with N2-type TANs known for their pro-tumor characteristics. This study introduces CT-1, derivative cryptotanshinone that effectively suppresses TNBC growth while selectively reducing proportion within tumor tissue. Notably, CT-1 induces simultaneous ferroptosis both cells, dual mechanism enhances its therapeutic efficacy. The identifies ferritin heavy chain 1...
Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction (MI) heart failure (HF). Here, we report novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively reversed infarction-induced myocardial and improved cardiac function by directly acting on cardiomyocyte to reverse hypertrophy. The effect HHQ16 was associated with strong inhibition newly discovered Egr2-affiliated transcript lnc9456 in heart. While minimally...
The aberrant activation of STAT3 is associated with the etiology and progression in a variety malignant epithelial-derived tumors, including head neck squamous cell carcinoma (HNSCC) colorectal cancer (CRC). Due to lack an enzymatic catalytic site or ligand-binding pocket, there are no small-molecule inhibitors directly targeting that have been approved for clinical translation. Emerging proteolysis chimeric (PROTAC) technology–based approach represents potential strategy overcome...
A novel approach was developed for the synthesis of 2-substituted-3-functionalized benzofurans, using an intramolecular Heck reaction which further applied in first enantioselective total Daphnodorin B.
A series of L-di-2-thenoyltartaric acid lanthanide coordination polymers, namely, {[La2L3(CH3OH)6(H2O)]·CH3OH·H2O}n (1), {[Ln2L3(CH3OH)x(H2O)6−x]·aCH3OH·bH2O}n, [Ln = Eu (2), x 2, a 0.5, b 0.25; Ln Gd (3), 3, 1, 0; Tb (4), 0], {[(Eu0.037Tb0.963)2L3(CH3OH)2(H2O)4]·CH3OH·2.75H2O}n (5), {[(Eu0.051Tb0.406La0.543)2L3(CH3OH)2(H2O)4]·0.5CH3OH·2H2O}n (6), and {[(Eu0.068Tb0.363Gd0.569)2L3(CH3OH)3(H2O)3]·CH3OH·H2O}n (7), have been synthesized using facile reactions H2L (H2L acid) with LnCl3·6H2O under...
As a therapeutic target for antitumor necrosis factor (TNF)-α interventions, UbcH5c is one of the key ubiquitin-conjugating enzymes catalyzing ubiquitination during TNF-α-triggered nuclear kappa B (NF-κB) activation. In present study, three series analogues were designed and synthesized from α-santonin, their inhibitory activities screened by Western blotting NF-κB luciferase assay. Further BIAcore, in-gel fluorescence imaging, immunoprecipitation assays demonstrated that compound 6d...
A series of five benzoyltrifluoroacetone Er(<sc>iii</sc>) complexes with various azacyclo-auxiliary ligands exhibit unique NIR luminescence and may be potential materials in optical amplifiers.
As one of the common malignant cancer types, gastric (GC) is known for late-stage diagnosis and poor prognosis. Overexpression receptor tyrosine kinase MET associated with prognosis among patients advanced stage GC. However, no inhibitor has been used GC treatment. Like other inhibitors that fit "occupancy-driven" model, current are prone to acquired resistance. The emerging proteolysis targeting chimera (PROTAC) strategy could overcome such limitations through direct degradation target...
Abstract: A series of triazole antifungal agents with piperidine side chains was designed and synthesized. The results tests against eight human pathogenic fungi in vitro showed that all the compounds exhibited moderate-to-excellent activities. Molecular docking between 8d active site Candida albicans CYP51 provided based on computational results. interacts iron heme group. difluorophenyl group is located S3 subsite its fluorine atom (2-F) can form H-bonds Gly307. chain oriented into S4...
Abstract: A series of novel derivatives phenyl-substituted berberine triazolyls has been designed and synthesized via copper-catalyzed azide-alkyne cycloaddition click chemistry in an attempt to develop antitumor agents. All the compounds were evaluated for anticancer activity against a panel three human cancer cell lines, including MCF-7 (breast), SW-1990 (pancreatic), SMMC-7721 (liver) noncancerous umbilical vein endothelial (HUVEC) lines. The results indicated that most displayed notable...