A5101981848- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Lung Cancer Treatments and Mutations
- Retinoids in leukemia and cellular processes
- Advanced Breast Cancer Therapies
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Bone health and treatments
- Antifungal resistance and susceptibility
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Axon Guidance and Neuronal Signaling
- FOXO transcription factor regulation
- Peptidase Inhibition and Analysis
- Pharmacological Effects of Natural Compounds
- Dermatologic Treatments and Research
- Psoriasis: Treatment and Pathogenesis
Zunyi Medical University
2015-2025
China Agricultural University
2025
Zhejiang Chinese Medical University
2009-2024
Nanchang University
2019-2024
Shenyang Pharmaceutical University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2020-2023
Hunan Cancer Hospital
2018-2023
Yangzhou University
2023
Huzhou University
2023
Guangdong Academy of Medical Sciences
2023
Decline of antioxidant defense after estrogen deficiency leads to oxidative damage in bone marrow-derived mesenchymal stem cells (BMMSCs), resulting a defect formation osteoporosis. Forkhead box O1 (FoxO1) protein is crucial for defending physiological bone. But whether FoxO1 involved the during osteoporosis largely unknown. In this study, we found that accumulation was decreased BMMSCs ovariectomized mice. The decrease resulted suppression manganese superoxide dismutase (Sod2) and catalase...
Background: Arterial calcification is a major event in the progression of atherosclerosis. It reported that statins exhibit various protective effects against vascular smooth muscle cell (VSMC) inflammation and proliferation cardiovascular remodeling. Although counteract atherosclerosis, molecular mechanisms on calcium release from VSMCs have not been clearly elucidated. Methods: Calcium content was measured using enzyme-linked immunosorbent assay (ELISA). The expression proteins involved...
PurposeIn cancer patients, tumor gene mutations contribute to drug resistance and treatment failure. In patients with metastatic breast (MBC), these increase after multiline treatment, thereby decreasing efficiency. The aim of this study was evaluate mutation patterns in MBC predict disease progression.MethodA total 68 who had received were recruited. Circulating DNA (ctDNA) evaluated compared among hormone receptor (HR)/human epidermal growth factor 2 (HER2) subgroups.ResultsThe baseline...
The long non-coding RNA (lncRNA) HOX transcript antisense (HOTAIR) plays a crucial role in cancer progression, which is regulated by the interferon regulatory factor-1 (IRF1) and up-streaming Akt activation. present study evaluated chemopreventive effects of delphinidin-3-glucoside (Dp), major anthocyanin pigmented fruits vegetables, on breast carcinogenesis, investigate Akt/HOTAIR signaling pathway.Human epithelial cells MCF10A were treated with carcinogens (NNK B[a]P) or co-treated plus Dp...
Patients with HER2-positive (HER2+) metastatic breast cancer (MBC) have poor prognoses. Pyrotinib has shown promising antitumor activity in MBC to improve progression-free survival (PFS). However, findings based on real-world data analyze whether pyrotinib affects overall (OS) remain scarce.This study is an exploratory analysis of brain metastasis (BM) and the final update our preceding 168 patients HER2+ MBC. PFS, OS, tumor mutation burden (TMB), clinical benefit rate (CBR), response (ORR)...
The KAI1 gene maps to chromosome 11p11.2, is a metastasis-suppressor for human prostate cancer and also involved in the progression of pancreatic non-small cell lung cancer. Recently, we showed that introduction single copy normal, neomycin-tagged 11 into highly metastatic MDA-MB-435 breast cells suppressed metastasis. Concomitantly, levels were higher 11/MDA-MB-435 clones. purpose this study was test whether expression indicative metastasis using panel immortalized epithelial lines...
Abstract Psoriasis is a common chronic inflammatory disease of the skin characterized by epidermal hyperplasia and angiogenesis. Recently, vascular endothelial growth factor receptors (VEGFRs, including VEGFR‐1, VEGFR‐2 VEGFR‐3) were found to be expressed in normal human epidermis associated with proliferation migration keratinocytes. The purpose this study investigate expression VEGFRs on psoriatic keratinocytes roles calcium VEGF regulating VEGFR expression. Skin samples from 17 patients...
Abstract Background Pulmonary tele-rehabilitation can improve adherence to pulmonary rehabilitation. However, there are few reports on home based tele-rehabilitation. We assessed the effectiveness of under telemedicine system in patients with chronic obstructive disease (COPD). Methods This cohort study enrolled 174 COPD who received system. The follow-up time was 12 weeks. Patients were grouped according rehabilitation weeks, number times and total duration time, when these three data...
Photoaging decreases quality of life and increases the risk skin cancer, underscoring urgent need to explore natural, high-efficacy, anti-skin photoaging (SP) active substances.In this study, a gel (CS/CSCPs/β-GP gel) was prepared using chitosan (CS) sodium β-glycerophosphate (β-GP) through crosslinking with small molecular CSCPs as carried drug. We evaluated its structural characteristics properties. The effect CS/CSCPs/β-GP on degree ultraviolet (UV)-induced aging mice investigated...
Vascular endothelial growth factor (VEGF) promotes angiogenesis and plays important roles in neovascularization development of tissues. VEGF receptors (VEGFRs) are high-affinity for originally considered specific to cells. We have previously shown that keratinocytes from human normal skin express VEGFRs. This poses the question whether these also expressed by epidermal appendages, as appendages lined with epithelial cells.To investigate expression VEGFR-2 compare including hair follicles,...
To investigate whether the apoptotic activities of 8-bromo-7-methoxychrysin (BrMC) involve reactive oxygen species (ROS) generation and c-Jun N-terminal kinase (JNK) activation in human hepatocellular carcinoma cells (HCC).HepG2, Bel-7402 L-02 cell lines were cultured vitro effects BrMC evaluated by flow cytometry (FCM) after propidium iodide (PI) staining, caspase-3 activity using enzyme-linked immunosorbent assay (ELISA), DNA agarose gel electrophoresis. ROS production was FCM...
The WD40 repeat proteins are crucial components of eukaryotic genomes and contribute to a wide array plant developmental processes environmental interactions. However, the true extent intraspecific diversity in plants is unclear. We defined nearly complete species-wide pan-WD40ome maize based on published genome sequences 26 nested association mapping (NAM) population founders. largely saturated with inclusion approximately 20 inbred lines, about 95% being present at least two architectural...
The oriental latrine fly, Chrysomya megacephala (Diptera: Calliphoridae), is a medically important synanthropic blow fly species characterized by its necrophagy and coprophagy, often observed near carrion animal feces. Notably, C. always arrives at carcass earlier than other species. To elucidate the underlying mechanisms behind host choice in megacephala, we present chromosome-scale genome assembly for this size 816.79 Mb, with contig N50 of 1.60 Mb. Hi-C data were anchored to six...
We have characterized two Drosophila POU genes designated dPOU-19 and dPOU-28. These are transcribed as 3.1- 2.2-kilobase mRNAs, respectively, which accumulate maximally during the first 12 hr of embryogenesis. The mRNAs encode 601- 475-amino acid deduced proteins; their domains most related to those human OCT1 OCT2. Both give similar nervous system expression patterns map an indistinguishable site at 33F on cytological map. Transcription is observed in cellular blastoderm. In course...
The mitochondrial DNA (mtDNA) control region is believed to play an important biological role in mtDNA replication. Large deletions this are rarely found, but when they do occur might be expected interfere with the replication of molecule, thus leading a reduction copy number. During survey for sequence variations 5,559 individuals from general Chinese population and 2,538 medical disorders, we identified 50-bp deletion (m.298_347del50) member healthy Han family belonging haplogroup B4c1b2,...
We, the Editors and Publisher of journal Artificial Cells, Nanomedicine, Biotechnology, have retracted following article:Xiaohong Yang, Yimin Yan, Yuhuan Chen, Jingwen Li & Jing Yang (2019) Involvement NORAD/miR-608/STAT3 axis in carcinostasis effects physcion 8-O-β-glucopyranoside on ovarian cancer cells. 47(1), 2855–2865, DOI: 10.1080/21691401.2019.1637884Since publication, concerns been raised about integrity data article. When approached for an explanation, authors unable to verify their...
Statement of RetractionStatement RetractionWe, the Editors and Publisher journal Cell Cycle, have retracted following article:Nan Li, Qi Gao, Wenli Zhou, Xiaoming Lv, Xiaohong Yang, Xiaoqi Liu. MicroRNA-129-5p affects immune privilege apoptosis nucleus pulposus cells via regulating FADD in intervertebral disc degeneration. Cycle. 2020;19(8):933-948. doi: 10.1080/15384101.2020.1732515.Since publication, significant concerns been raised about integrity data reported results article. When...