A5055627916- Pluripotent Stem Cells Research
- Infant Nutrition and Health
- Reproductive Biology and Fertility
- 3D Printing in Biomedical Research
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Liver physiology and pathology
- Molecular Biology Techniques and Applications
- Animal Genetics and Reproduction
- Circular RNAs in diseases
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Analytical chemistry methods development
- Drug-Induced Adverse Reactions
- Extracellular vesicles in disease
- Pharmacovigilance and Adverse Drug Reactions
- Breastfeeding Practices and Influences
- Selenium in Biological Systems
- Peptidase Inhibition and Analysis
- Renal and related cancers
- Reproductive System and Pregnancy
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Pregnancy and preeclampsia studies
First Hospital of Jilin University
2011-2025
Jilin University
2013-2025
Northeast Agricultural University
2023-2025
Ministry of Education of the People's Republic of China
2025
Shanghai Changzheng Hospital
2018-2022
United States Department of the Navy
2022
Second Hospital of Shanxi Medical University
2019-2022
Shanxi Medical University
2019-2022
Xiamen University
2022
Hebei Medical University
2022
Trial Design Oral ibuprofen has demonstrated good effects on symptomatic patent ductus arteriosus (PDA) but with many contraindications and potential side-effects. In the past two years, oral paracetamol administration to several preterm infants PDA been reported. Here, a randomized, non-blinded, parallel-controlled non-inferiority trial was designed evaluate efficacy safety profiles of those standard for closure in premature infants. Methods One hundred sixty (gestational age ≤34 weeks)...
Abstract Despite major progress in the knowledge and management of human liver injury, there are millions people suffering from chronic disease. Currently, only cure for end-stage disease is orthotopic transplantation; however, this approach severely limited by organ donation. Alternative approaches to restoring function have therefore been pursued, including use somatic stem cell populations. Although such essential developing scalable treatments, also an imperative develop predictive...
Previous studies have demonstrated that microRNAs (miRs) are involved in the carcinogenesis of colorectal cancer (CRC). To best our knowledge, function and regulatory role miR-532-5p human CRC remains unknown. The aim present study was to determine regulation CRC. Using reverse transcription-quantitative polymerase chain reaction, it upregulated, whereas runt-related transcription factor 3 (RUNX3) downregulated tissues. upregulated associated with RUNX3. Furthermore, two biomarkers were...
Long non-coding RNA (LncRNA) HOX transcript antisense (HOTAIR) and Yin Yang 1 (YY1) are reported to be involved in tumorigenesis. However, the effect molecular mechanism of HOTAIR on YY1 expression remains poorly understood. The study aimed investigate functions LncRNA medulloblastoma progression.qPCR was performed detect mRNA tissues cells, as well that miR-1 miR-206 levels. Western blot assay used test EMT-related biomarkers' protein Cell proliferation tested with CCK-8 colony formation...
The coordination of signalling pathways within the cell is vital for normal human development and post-natal tissue homeostasis. Gene expression function therefore tightly controlled at a number levels. We investigated role that post-translational modifications play during hepatocyte differentiation. In particular, we examined small ubiquitin-like modifier (SUMO) proteins in this process. used embryonic stem (hESC)-based model differentiation to follow changes protein SUMOylation. Moreover,...
In tissue engineering, cells are generally cultured in biomaterials to generate three-dimensional artificial tissues repair or replace damaged parts and re-establish normal functions of the body. Characterizing cell growth viability these bioscaffolds is challenging, currently achieved by destructive end-point biological assays. this study, we explore potential use electrical impedance tomography (EIT) as a label-free non-destructive technology assess viability. The key challenge engineering...
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria. Impaired trophoblast invasion partly modulated abnormal MAPK1/ERK2 signaling played important roles in the pathological process of preeclampsia. The objective this study to investigate miR-141-5p regulate ATF2 via effecting promote preeclampsia.The maternal placentae clinical data 30 patients with preeclampsia healthy pregnant women were collected Second Hospital Shanxi Medical University from July...
Abstract Background Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze risk factors for LO-NEC, impact LO-NEC on short-term outcomes very infants (VPIs) with focus nutrition different onset times. Method Clinical data VPIs were retrospectively...
Abstract Reproductive efficiency using somatic cell nuclear transfer (SCNT) technology remains suboptimal. Of the various efforts to improve efficiency, chromatin (CT) and clone‐clone aggregation (NTagg) have been reported produce live cloned animals. To better understand molecular mechanisms of reprogramming during SCNT assess methods on level, we performed gene expression analysis bovine blastocysts produced via standard (NT), CT, NTagg, in vitro fertilization (IVF), artificial...
The manufacturing processes for infant formula disrupt the structure of phospholipid-coated milk fat globules, thereby impacting physical stability system. In this study, either soybean phospholipids (SPs) or egg yolk (EYPs) were incorporated into system to reduce damage, and their effects on globule processed examined. findings revealed that addition improved different milk. pasteurized milk, constant samples with decreased from 0.42 0.37 compared phospholipid-free but no significant...
Clostridium butyricum (C. butyricum), a normal gut bacterium in humans, is commonly used as probiotic. We described 26-day-old premature neonate who was diagnosed with probiotic-related C. meningitis. Upon the admission, suppurative meningitis considered based on cerebrospinal fluid (CSF) biochemical test and neuroimaging examination, subsequently identified by CSF metagenomic next-generation sequencing. Given history of administrating living products before probiotics-associated high...
To investigate the incidence of extrauterine growth retardation (EUGR) and its risk factors in very preterm infants (VPIs) during hospitalization China.A prospective multicenter study was performed on medical data 2 514 VPIs who were hospitalized department neonatology 28 hospitals from 7 areas China between September 2019 December 2020. According to presence or absence EUGR based evaluation body weight at corrected gestational age 36 weeks discharge, classified two groups: group (n=1 189)...
Statement of RetractionStatement RetractionWe, the Editors and Publisher journal Cell Cycle, have retracted following article:Nan Li, Qi Gao, Wenli Zhou, Xiaoming Lv, Xiaohong Yang, Xiaoqi Liu. MicroRNA-129-5p affects immune privilege apoptosis nucleus pulposus cells via regulating FADD in intervertebral disc degeneration. Cycle. 2020;19(8):933-948. doi: 10.1080/15384101.2020.1732515.Since publication, significant concerns been raised about integrity data reported results article. When...
Abstract Pre‐implantation embryos produced by somatic cell nuclear transfer (SCNT) have varied developmental potentials. The majority of SCNT blastocysts do not develop to term, and the mechanisms inhibiting development are still largely unknown. Aggregation cloned has been attempted compensate for deficiency individual embryos. In this report, we investigated impact aggregation bovine at four‐cell stage on in vitro gene expression Cell numbers rate aggregated (NTagg) non‐aggregated (NT)...