Xin-Zhu Lin
A5051586931- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Clinical Nutrition and Gastroenterology
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Infant Development and Preterm Care
- Preterm Birth and Chorioamnionitis
- Breastfeeding Practices and Influences
- Neonatal and Maternal Infections
- Pregnancy and preeclampsia studies
- Neonatal and fetal brain pathology
- Gestational Diabetes Research and Management
- X-ray Diffraction in Crystallography
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Crystallization and Solubility Studies
- Neonatal Health and Biochemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Streptococcal Infections and Treatments
- Metabolism and Genetic Disorders
- Advanced Memory and Neural Computing
- Metabolomics and Mass Spectrometry Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hemophilia Treatment and Research
Children’s Hospital of Fudan University Xiamen Branch
2021-2025
Xiamen University
2021-2025
China Three Gorges University
2025
Yichang Central People's Hospital
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Dalian Medical University
2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Fujian Medical University
2025
<h3>Importance</h3> The Chinese Neonatal Network was established in 2018 and maintains a standardized national clinical database of very preterm or low-birth-weight infants tertiary neonatal intensive care units (NICUs) throughout China. National-level data on outcomes practices (VPIs) China are lacking. <h3>Objective</h3> To assess the NICUs among VPIs <h3>Design, Setting, Participants</h3> A cohort study conducted comprising 57 hospitals from 25 provinces All with gestational age (GA) less...
The overutilization of antibiotics in very preterm infants (VPIs) at low risk early-onset sepsis (EOS) is associated with increased mortality and morbidities. Nevertheless, the association early antibiotic exposure bronchopulmonary dysplasia (BPD) remains equivocal.
Abstract Background Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze risk factors for LO-NEC, impact LO-NEC on short-term outcomes very infants (VPIs) with focus nutrition different onset times. Method Clinical data VPIs were retrospectively...
Efficient dioxygen (O2) activation under mild and environmentally friendly conditions remains a challenging yet crucial research area in chemistry. In this study, by rationally modulating the coordination environment of Cu(I)...
The atherogenic index of plasma (AIP) can be used to reveal atherosclerosis. This study evaluated the AIP's efficacy in predicting prognosis acute kidney injury (AKI) and severity pancreatitis (AP). retrospective cohort recruited AP cases from First College Clinical Medical Science China Three Gorges University between January 2019 October 2023, including 1470 patients. AIP was computed using formula: log10 [serum triglyceride (mmol/L)/serum high-density lipoprotein cholesterol (mmol/L)]....
Abstract Background: Patients with EGFR-positive non-small cell lung cancer (NSCLC) do not respond as well to immunotherapy patients without an EGFR mutation. Nevertheless, recent studies indicate that subsequent following EGFR-TKI treatment may be effective in NSCLC. Given the critical role of tumor immune microenvironment (TIME) determining efficacy, understanding influence on TIME NSCLC remains important yet unresolved area research. Methods: Single-cell RNA sequencing (scRNA-seq) was...
Abstract Objective This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight 1500 g (VLBWI) to provide an evidence-based medicine basis for optimizing intravenous emulsion. Methods was a prospective multicenter randomized controlled study. A total 465 VPIs VLBWIs, admitted neonatal intensive care unit five tertiary hospitals China from March 1, 2021 December 31, 2021, were recruited. All subjects...
To analyse early risk factors for mortality in preterm infants treated with inhaled nitric oxide (iNO) China. A retrospective observational case-control study. 8 tertiary hospitals 5 regions of 726 iNO hypoxic respiratory failure or persistent pulmonary hypertension newborns. None. The primary outcome was survival status at discharge. (1) rate 27.1% (197/726), and which significantly reduced increasing gestational age (GA) birth weight. (2) Compared the group, death group had greater use...
The prevalence of attention deficit-hyperactivity disorder (ADHD) symptoms among individuals with cystic fibrosis (CF) is significantly elevated compared to the general population. Given that transmembrane conductance regulator (CFTR) causative gene for fibrosis, this raises possibility CFTR playing a crucial role in ADHD. In our study, three heterozygous missense variants (p.E217G, p.F316L, and p.T1220I) were detected gene, which co-segregate ADHD two consanguineous families, impacting...
The management of enteral nutrition in very preterm infants (VPIs) is still controversial, and there no consensus on the optimal time point after birth at which can be started. aim this study was to investigate effect early initiation short-term clinical outcomes VPIs.Data (n = 2514) born before 32 wk gestation were collected from 28 hospitals located seven different regions China. Based whether feeding initiated within or 24 h since birth, divided into an (EIEF) group a delayed (DIEF)...
To examine the risk factors for severe bronchopulmonary dysplasia (BPD) in a cohort of very preterm infants (VPIs) China, as BPD is common among VPIs and associated with high mortality rate.
The aim of this study was to investigate the effects soybean, medium-chain triacylglycerols (MCTs), olive oil, and fish oil (SMOF) on short-term clinical outcomes, physical growth, extrauterine growth retardation (EUGR) in very preterm infants.
Objectives To investigate the risk profile of preterm birth (PTB) in 2018 China. Method A prospective multicentre case–control study was conducted 15 hospitals located seven provinces throughout three geographical areas (the Eastern, South‐Central and North‐Western regions) total 3147 (<37 +0 weeks) term (37 to 41 +6 live‐birth mothers were included. Designed questionnaires used maternal fetal information. We calculated multivariable logistic regression population attributable (PAR)....
Background Circadian rhythms impact metabolism and the therapeutic effects of drugs. The purpose this study was to determine association between PER CRY polymorphisms caffeine citrate treatment response in infants with apnea prematurity. Methods A total 221 preterm gestational age &lt;34 weeks were included (160 group 61 non-response group). propensity score matching method used perform a 1:1 for all premature infants, general characteristics clinical outcomes two groups compared....
Infants with rule-out infections are responsible for the majority of empirical antibiotics treatment (EAT) in neonatal intensive care units (NICUs), particularly very preterm infants (VPIs). Antibiotic overuse has been linked to adverse outcomes. There is a paucity data on association between EAT and clinical outcomes (containing nutritional outcomes) VPIs without infection-related morbidities.Clinical admitted 28 hospitals 20 provinces China from September 2019 December 2020 were collected....
Abstract Background To analyze the real-world growth pattern of very premature infants (VPI) with small for gestational age (SGA) after birth by using ΔZ value weight at discharge. Methods The clinical data were collected from 28 hospitals in China September 2019 to December 2020. They divided into EUGR(Extrauterine Growth Restriction) and non-EUGR group according criterion discharge < –1.28. Results This study included 133 eligible VPI SGA. Following value, incidence EUGR was 36.84%...
Objective: To describe the clinical presentation and novel mutation in coxsackie adenovirus receptor-like membrane protein (CLMP) gene a Chinese family with congenital short bowel syndrome (CSBS). Methods: We collected data from inherited CSBS, performed whole exon sequencing of children their parents. The pathogenic sites candidate genes were targeted, detected deletions verified by quantitative PCR. Results: Two siblings this presented bilious vomiting, diagnosed CSBS on laparotomy....
To investigate the protective effect of high-proportion breast milk feeding (>50%) on intraventricular hemorrhage (IVH) in very preterm infants (VPIs).This was a retrospective secondary analysis prospective multi-center study, which included 604 VPIs from six hospitals eastern China between September 2019 and December 2020. The were divided into two groups according to whether IVH occurred. High-proportion defined as accounting for 51-100% total amount both within 7 days throughout...
The prevalence of preterm birth has been rising, and there is a paucity nationwide data on the perinatal characteristics neonatal outcomes twin deliveries very infants (VPIs) in China. This study compared singletons twins admitted to intensive care units (NICUs) China.The population comprised all born before 32 weeks Chinese Neonatal Network (CHNN) between January 2019 December 2019. Three-level population-average generalized estimating equation (GEE)/alternating logistic regression (ALR)...
Adequate supply of long-chain polyunsaturated fatty acids (LCPUFAs) is great importance for neonates, especially preterm infants. In particular, n-3 LCPUFAs and n-6 play a key role in brain development, immune regulation, disease prevention. Lack may lead to neurodevelopmental impairment, affect the development neonatal system, result diseases. This article reviews related research advances physiological function its effect on so as provide reference clinical application.
Paired-like homeobox (PHOX)2B is considered to be the causative gene of congenital central hypoventilation syndrome (CCHS), a dominant genetic disorder that results in abnormal respiratory control with resulting during sleep. In this study, we report novel c.676_677insG (p.Ala226fs) mutation patient severe CCHS, and evaluated function mutation. The reduced translation mutant PHOX2B protein impaired its ability activate PHOX2A promoter, due haploinsufficiency effect. was able interact...
Background Hyperglycemia in pregnancy (HGP) has generally been considered a risk factor associated with adverse outcomes offspring, but its impact on the short-term of very preterm infants remains unclear. Methods A secondary analysis was performed based clinical data collected prospectively from 28 hospitals seven regions China September 2019 to December 2020. According maternal HGP, all were divided into HGP group or non-HGP group. propensity score matching used adjust for confounding...