A5100336920- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Circular RNAs in diseases
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy and preeclampsia studies
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Birth, Development, and Health
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Systemic Lupus Erythematosus Research
- Erythrocyte Function and Pathophysiology
- Virus-based gene therapy research
- Reproductive System and Pregnancy
- Thyroid and Parathyroid Surgery
- Diabetes and associated disorders
- Diabetes Management and Research
China Medical University
2016-2025
Beijing Tian Tan Hospital
2024-2025
Shanghai Jiao Tong University
2009-2025
Capital Medical University
2013-2025
First Hospital of China Medical University
2015-2025
Huashan Hospital
2018-2025
Fudan University
2018-2025
Dalian Medical University
2017-2025
The Barbara Ann Karmanos Cancer Institute
2018-2025
Xuzhou Medical College
2012-2025
Abstract Background Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and receiving maximal medical support, have been noted to progress irreversible fatal respiratory failure. Lung transplantation (LT) as sole therapy for end-stage pulmonary fibrosis related acute distress syndrome has considered ultimate rescue these patients. Methods From February 10 March 10, 2020, three male were urgently assessed listed...
Objective Metabolic syndrome is a common condition among middle-aged and elderly people. Recent studies have reported the association between obesity- lipid-related indices metabolic syndrome, but whether those conditions could predict still inconsistent in few longitudinal studies. In our study, we aimed to by Chinese adults. Method A national cohort study that consisted of 3,640 adults (≥45 years) was conducted. total 13 indices, including body mass index (BMI), waist circumference (WC),...
Background: As new biomarkers of coronary artery diseases (CAD) emerge via metabolomics, the underlying functional mechanisms remain to be elucidated. Functional metabolomics aims translate metabolomics-derived disease mechanisms. Methods: A cohort 2324 patients who underwent angiography from 4 independent centers was studied. combination ultra–performance liquid chromatography and quadrupole time-of-flight mass spectrometry in negative ion mode used for untargeted analysis metabolites...
Chronic infection, such as Helicobacter pylori has been associated with the development of gastric cancer (GC). Pathogen-associated molecular patterns can trigger inflammatory responses via Toll-like receptors (TLRs) in GC. Here we showed that receptor 4 (TLR4) was highly expressed GC cells and aggressiveness The binding lipopolysaccharide (LPS) to TLR4 on enhanced proliferation without affecting apoptosis. Higher level reactive oxygen species (ROS) induced after activation signaling Using...
Lung cancer, predominantly by non-small cell lung cancer (NSCLC), is the leading cause of cancer-related deaths over world. Late diagnosis one important reasons for high mortality rate in cancer. Current diagnostic approaches have disadvantages such as low accuracy, cost, invasive procedure, etc. MicroRNAs were previously proposed promising novel biomarkers screening. In this study, we evaluated predictive power four candidate miRNAs NSCLC detection. Our study involved 152 patients and 300...
Background— Postoperative atrial fibrillation is a frequent complication in cardiac surgery. The aberrant activation of signal transducer and activator transcription 3 (STAT3) contributes to the pathogenesis fibrillation. MicroRNA-21 (miR-21) promotes fibrosis. Recent studies support existence reciprocal regulation between STAT3 miR-21. Here, we test hypothesis that these 2 molecules might form feedback loop postoperative by promoting Methods Results— A sterile pericarditis model was created...
The actuator failure compensation control problem of robotic systems possessing dynamic uncertainties has been investigated in this paper. Control design against partial loss effectiveness (PLOE) and total (TLOE) the are considered described, respectively, a disturbance observer (DO) using neural networks is constructed to attenuate influence unknown disturbance. Regarding prescribed error bounds as time-varying constraints, method based on barrier Lyapunov function (BLF) used strictly...
The unintended exposure of humans and animals to isothiazolinones has led an increasing concern regarding their health hazards. Isothiazolinones were previously found disrupt reproductive endocrine homeostasis. However, the long-term toxicity underlying mechanism remain unclear. In this study, life-cycle medaka dichlorocthylisothiazolinone (DCOIT), a representative isothiazolinone, significantly stimulated gonadotropin releasing hormone receptor (GnRHR)-mediated synthesis follicle...
Thyroid parameters undergo significant dynamic changes during pregnancy. This study aimed to comprehensively analyze the impact of abnormal thyroid in each trimester on incidence common adverse obstetric outcomes. Blood samples drawn for antenatal period were determined after participants gave birth. Serum thyrotropin, free thyroxine, triiodothyronine, anti-thyroid peroxidase antibody (TPOAb), and anti-thyroglobulin (TgAb) levels tested using electrochemiluminescence immunoassays. Among all...
Abstract Purpose: To evaluate the effects of ritonavir, a potent inhibitor CYP3A4, on steady-state pharmacokinetics imatinib. Experimental Design: Imatinib were evaluated in cancer patients receiving drug for at least 2 months, after which ritonavir (600 mg) was administered daily 3 days. Samples obtained day before (day 1) and third 4). The vitro metabolism imatinib with or without effect 1-OH-midazolam formation rate, probe CYP3A4 activity, human pooled liver microsomes. Results: In 11...
Abstract Breast cancer is molecularly heterogeneous and categorized into four molecular subtypes: Luminal-A, Luminal-B, HER2-amplified Triple-negative. In this study, we aimed to apply an ensemble decision approach identify the ultrasound clinical features related subtypes. We collected from 1,000 breast patients performed immunohistochemistry on these samples. used select unique construct models. The model for Luminal-A subtype was constructed based presence of echogenic halo post-acoustic...
Background: MicroRNAs (miRNAs) are important diagnostic and prognostic markers in cancer. In the study reported here, we analyzed potential relationship between miRNA expression extrathyroidal invasion papillary thyroid carcinoma (PTC). Methods: Samples from 91 patients with PTC were collected January 2008 to April 2012 at our hospital. To detect levels of fresh frozen tissues (n = 3) non-extrathyroidal 3), array was carried out. The upregulated miRNAs two groups confirmed by using real-time...
Increasing evidence demonstrated that exogenous plant miRNAs in the diet can be absorbed and are found mammalian tissues.These influence physiological pathological progression of recipient.In this issue, Jing Li colleagues further reveal exogenous/ endogenous small non-coding RNA maternal system transfer through placenta to fetal side development health.These surprising finding demonstrate profiling very important development, which means healthy status may postnatal morbidity via...
The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role development and progression PTC through receptors (ERs). This study aimed to investigate expression patterns two main ER subtypes, α β1 (wild-type ERβ), tissue their clinical significance. Immunohistochemical staining sections was performed detect female patients with (n = 89) nodular goiter (NTG; n 30)...