A5082686687- IL-33, ST2, and ILC Pathways
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
- Mechanical Circulatory Support Devices
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Immune cells in cancer
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- RNA Interference and Gene Delivery
- melanin and skin pigmentation
- Cytokine Signaling Pathways and Interactions
- Organ and Tissue Transplantation Research
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Immune Response and Inflammation
- Skin Protection and Aging
- Atherosclerosis and Cardiovascular Diseases
- Acupuncture Treatment Research Studies
- Pulmonary Hypertension Research and Treatments
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Gastrointestinal disorders and treatments
Hebei Medical University
2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2025
Guangdong Pharmaceutical University
2021-2025
Shanghai Institute of Technology
2025
Beihang University
2025
National Medical Products Administration
2022-2024
Shenzhen University
2024
Peking University
2019-2024
Nankai University
2008-2023
Wuxi People's Hospital
2020-2022
Background: Sporadic aortic aneurysm and dissection (AAD), caused by progressive smooth muscle cell (SMC) loss extracellular matrix degradation, is a highly lethal condition. Identifying mechanisms that drive degeneration crucial step in developing an effective pharmacologic treatment to prevent disease progression. Recent evidence has indicated cytosolic DNA abnormal activation of the sensing adaptor STING (stimulator interferon genes) play critical role vascular inflammation destruction....
Abstract Background Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and receiving maximal medical support, have been noted to progress irreversible fatal respiratory failure. Lung transplantation (LT) as sole therapy for end-stage pulmonary fibrosis related acute distress syndrome has considered ultimate rescue these patients. Methods From February 10 March 10, 2020, three male were urgently assessed listed...
This study was designed to establish if Curcumin (CM) alleviates Aflatoxin B₁ (AFB₁)-induced hepatotoxic effects and determine whether alteration of the expression cytochrome P450 (CYP450) isozymes is involved in regulation these chick liver. One-day-old male broilers (
To investigate whether the transfer of IL-37b gene, a newly identified inhibitor both innate and adaptive immunity, could improve therapeutic efficacy mesenchumal stromal cells (MSCs) in inflammatory bowel disease (IBD). The expression IL-37 biopsied specimens patients with active ulcerative colitis (UC) was detected using RT-PCR immunohistochemistry. Mice were treated 3% dextran sulfate sodium (DSS) for 8 days to induce colitis. Before DSS treatment, mice injected MSCs, MSC-eGFP or...
Dendritic cell (DC) function is negatively affected by tumors and tumor-derived factors, but little known about the underlying mechanisms. Here, we show that intracellular SOCS3 in DCs binds to pyruvate kinase type M2 (M2-PK), which plays a critical role ATP production through glycolysis. The interaction of with M2-PK reduced impaired DC-based immunotherapy against tumors. Thus, SOCS3, has been shown be upregulated interacts decrease production, causing DC dysfunction. These dysfunctional...
Background. Splenectomy can improve liver function and survival in patients with autoimmune hepatitis (AIH) cirrhosis. We investigated the underlying mechanism a mouse model of concanavalin A- (ConA-) induced fibrosis. Methods. used ConA to induce immune fibrosis BALB/c mice. was performed alone or administration dexamethasone (DEX). Changes blood tissues were evaluated. Results. Mice treated for 7 weeks developed advanced fibrosis, while splenectomy suppressed Although populations...
BACKGROUND: Pulmonary hypertension is a devastating vascular disorder characterized by extensive pulmonary remodeling, ultimately leading to right ventricular failure and death. Activation of PDGF (platelet-derived growth factor) signaling promotes the hyperproliferation arterial smooth muscle cells (PASMCs), thus contributing remodeling. However, molecular mechanisms that govern PASMCs induced remain largely unknown, including contribution long noncoding RNAs (lncRNAs). In this study, we...
Abstract A quantum channel is usually represented as a sum of Kraus operators. The recent study [Phys. Rev. 98, 032328 (2018)] has shown that applying perturbation to the operators in qubit Pauli channels, dynamical maps exhibit interesting properties, such non-Markovianity, singularity. This sparked our interest studying properties other channels. In this work, we special class generalized Weyl where are proportional diagonal matrices and rest vanishing. We use Choi matrix intermediate map...
Boron arsenide (BAs) has emerged as a strong contender for next-generation functional materials, boasting desirable attributes such high thermal conductivity and ambipolar mobility. However, critical yet underexplored challenge lies in understanding its heat conduction capabilities under inhomogeneous strain, which is pivotal across various devices operational conditions. Here, through modeling transport bent BAs $\mathrm{Si}$ nanoribbons, striking difference revealed. Namely, the...
As the outermost barrier of body, skin is a major target oxidative stress. In brain, estrogen has been reported synthesized locally and protects neurons from Here, we explored whether also in to protect stress aberrant local synthesis involved disorders. Enzymes receptor expression cells were examined first by quantitative real-time PCR Western blot analyses. Interestingly, enzyme was mainly localized epidermal keratinocytes receptors expressed melanocytes among 13 kinds cultured human...
The gastrointestinal tract is the most common location for primary extranodal non‑Hodgkin lymphoma (NHL) with cases less commonly found in intestine. majority of intestinal B‑cell lymphomas are exophytic, whereas enteropathy‑associated T‑cell present predominantly as thickened plaques, ulcers or strictures. Crohn's disease (CD) a chronic inflammatory intestines fissures and ulcers, which difficult clinicians to diagnose based on endoscopic observations alone. Malignant must be considered...
Suppressor of cytokine signaling 3 (SOCS3) expression in bone marrow cells (BMC) was up-regulated upon exposure to interleukin 6, lipopolysaccharide, or tumor-associated factors. But, how the SOCS3 affects differentiation BMCs is incompletely characterized. Here, we showed that promoted intently differentiate into CD8 T cells. Importantly, lung can be as one athymus tissue for CD8(+) Notch1 plays a critical role from SOCS3-transfected We conclude some pathologic conditions, such tumor and...
<b><i>Background:</i></b> Gastrointestinal tumors originating from the muscularis propria are believed to have potential progress malignant tumors. The efficacy of ‘pre-management' with elastic band or endoloop assistant ligation after initial submucosal dissection in endoscopic enucleation procedure these was investigated and evaluated. <b><i>Methods:</i></b> study included 21 patients small gastric stromal arising as determined by endoscopy...
Glycoprotein non-metastatic melanoma protein B (GPNMB) is a type I transmembrane glycoprotein that plays an important role in cancer metastasis and osteoblast differentiation. In the skin epidermis, GPNMB mainly expressed melanocytes critical melanosome formation. our previous study, was also found to be epidermal keratinocytes. addition, decreased expression observed epidermis of lesional patients with vitiligo. However, exact keratinocyte-derived its effect on vitiligo still unknown. this...
Objective: To investigate the protective effect of Polygonum multiflorum extracts (EPM) on SH-SY5Y cells treated with MPP+. Methods: were first exposed to various doses EPM, and then The cell viability was detected MTT assay, morphology observed microscope by Hoechst33258 staining, level glutathione (GSH), Malondialdehyde (MDA) activity Lactate dehydrogenase (LDH) measured UV spectrophotometer. Reactive oxygen species (ROS) mitochondrial membrane potential fluorescence microscope. expression...