A5101645154- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Advanced MRI Techniques and Applications
- MicroRNA in disease regulation
- Connexins and lens biology
- Circular RNAs in diseases
- Cardiac Arrest and Resuscitation
- Anesthesia and Pain Management
- Fuel Cells and Related Materials
- Scoliosis diagnosis and treatment
- Inflammatory mediators and NSAID effects
- MRI in cancer diagnosis
- Cardiac pacing and defibrillation studies
- Ultrasound in Clinical Applications
- Eicosanoids and Hypertension Pharmacology
- Heart Rate Variability and Autonomic Control
- Congenital Heart Disease Studies
- Fungal Infections and Studies
- Infectious Diseases and Tuberculosis
- Viral Infections and Immunology Research
- Natural Compounds in Disease Treatment
- Advanced Neuroimaging Techniques and Applications
Shandong Sport University
2024
Nanjing Medical University
2020-2022
Wuxi People's Hospital
2009-2022
Guiyang Medical University
2019-2020
People's Hospital of Bishan District
2020
Linyi People's Hospital
2013-2017
Philips (China)
2015-2017
Shanghai Public Health Clinical Center
2010
Abstract Background Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and receiving maximal medical support, have been noted to progress irreversible fatal respiratory failure. Lung transplantation (LT) as sole therapy for end-stage pulmonary fibrosis related acute distress syndrome has considered ultimate rescue these patients. Methods From February 10 March 10, 2020, three male were urgently assessed listed...
Sufentanil, a potent opioid, serves as the first option for perioperative analgesia owing to its analgesic effect, long duration and stable hemodynamics, whereas side effects frequently blunt application. The intravenous (IV) injection of sufentanil during anesthesia induction has high incidence choking or bucking reaction, which is defined sufentanil-induced cough (SIC). Moreover, postoperative nausea vomiting (PONV) common stressful complication, also related usage opioid. High PONV...
The present study aimed to examine the mechanism of triptolide in treatment ankylosing spondylitis (AS) through anti‑ossification effect bone morphogenetic protein (BMP)/small mothers against decapentaplegic (Smad) pathway. Male rats were randomly divided into five groups: Normal rat group; model low dose group (10 mg/kg); middle (20 high (40 mg/kg). spinal joint capsules each collected perform primary cell culture determine levels proliferation. Western blot and reverse...
Abstract Background Hypothermic ischemia-reperfusion arrhythmia remains the main factor affecting cardiac resuscitation under cardiopulmonary bypass. Existing research shows that certain miRNAs exhibit significantly different expressions and effects in arrhythmias, however, effect of on progression hypothermic ischemic–reperfusion arrhythmias (RA) its potential mechanism remain to be further explored. Methods Sprague-Dawley (SD) rats were randomly divided into two groups ( n = 8): a normal...
To investigate the effect of sevoflurane on monophasic action potentials (MAPs) in isolated rat hearts after ischemia-reperfusion.Twenty-four healthy SD male rats, weighing 280-320 g, were randomly divided into three groups successful preparation a Langendorff heart perfusion model with stabilization period 15 min Krebs-Henseleit (K-H) fluid (n = 8): control group (group A, continuously perfused K-H for 105 min), ischemia-reperfusion B, min, and then exposed to 60 global ischemia induced by...
Background: Lactic acidosis is often seen in lung transplantation (LTx). Postoperative lactate frequently associated with poor outcome postoperative and critically ill patients. Our aim was to evaluate the predictive value of peak levels within 72 h LTx for 30-day late mortality. Methods: We evaluated patients who underwent from January 2015 September 2017. All admitted were classified according level (PL) surgery: PL <5 mmol/L (Group 1); =5–10 2), >10 3). performed logistic regression...
// Jinning Li 1, * , Caiyuan Zhang Yanfen Cui 1 Huanhuan Liu Weibo Chen 2 Guilong Wang and Dengbin Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School Medicine, 200092, China Philips Healthcare, 200233, These authors contributed equally to this work Correspondence to: Wang, email: wangdengbin@xinhuamed.com.cn Keywords: intravoxel incoherent motion, diffusion-weighted imaging, liver, repeatability, respiratory-cardiac double triggering Received: August 02,...
Extracorporeal membrane oxygenation (ECMO) is widely used for cardiopulmonary assistance during lung transplantation (LTx). However, the optimal timing ECMO removal remains controversial. This study aimed to evaluate risk factors and early prognosis of delayed withdrawal after LTx.Two hundred sixty-seven patients who underwent LTx supported by were included in this study. Based on whether or not was completely stopped operating room, divided into group (group E, 107 cases) D, 160 cases)....
To study the clinical manifestations and identify causative mutations for a Chinese family affected with X-linked Charcot-Marie-Tooth disease.Clinical, electrophysiological pathological features of were carefully analyzed by neurologists. Blood samples obtained from proband other members. Genomic DNA was extracted. Mutation analysis GJB1 gene PCR direct sequencing.The has fit inheritance, individuals have typical manifestations. A c.614A>G (p.Asn205Ser) mutation detected in all family.A is...
We established a model of hypothermic hypoxia/reoxygenation injury fibroblasts, simulated the process ischemia/reperfusion during cardiopulmonary bypass, and studied effects cardiac fibroblasts on cardiomyocyte activity, connexin 43 (Cx43), calmodulin kinase II (CaMKII) expression. Furthermore, sevoflurane-treated fibroblast culture medium Cx43 protein, CaMKII expression were observed. The results showed that damaged by could reduce beating frequency cardiomyocytes, increase mortality...
The study aimed to determine the role of inward rectifier potassium channel 2.1 protein and connexin 40 expressions in regulating duration repolarization conduction velocity right atrial myocardium rats following hypothermic ischemia-reperfusion.The Langendorff isolated rat cardiac perfusion models were divided into control (C) ischemia-reperfusion groups, with 8 group C 16 ischemia-reperfusion. Depending on incidence arrhythmia after reperfusion, further reperfusion non-atrial or subgroup....
Objective To determine the diagnostic value of cardiovascular magnetic resonance (CMR) in children with myocarditis. Methods A total 27 myocarditis were examined cardiac MRI, including 16 new-onset cases and 11 chronic cases, as well 14 non-myocarditis. Sequences included SSFP axial, two chamber, four chamber short axis, T2-weighted triple inversion recovery, T1-weighted spin echo before after gadolinium injection, recovery-gradient injection(late enhancement, LGE) axial axis....
Objective To assess the application value of high time-resolved MR angiography (TR-MRA) in postoperative follow-up study children with congenital heart diseases. Methods Seventy-three patients (median age 6 years, range 1-20 years) diseases who underwent TR-MRA scan after operation were retrospectively analyzed. Twenty-nine cases also performed conventional contrast-enhanced MRA and forty-four phase-contrast MRA. A 3D T1-weighted fast gradient-echo sequence was used for...
Objective To evaluate the value of pulse indicator continuous cardiac output (PiCCO) measurement during and after lung transplantation. Methods Eleven cases ASA class Ⅲ or Ⅳ aged from 34 to 68 years undergoing transplantation were enrolled in this randomized,double-blind trial (7 idiopathic pulmonary fibrosis patients, 3 COPD 1 case silicosis patent), CVP, Swan-Ganz, PiCCO catheter inserted all patients via subclavical vein, internal jugular vein left femoral artery respectively. The...
Objective To summarize the perioperative clinical effect of extracorporeal membrane oxygenation (ECMO) technique in bilateral lung transplantation patients with idiopathic pulmonary arterial hypertension. Methods Of 18 recipients hypertension receiving double transplantation, there were 11 cases grade Ⅲ (WHO cardiac function ratings) and 7 Ⅳ. All given ECMO after anesthetic induction, speed volume adjusted according to function. At end operation, flow rate was decreased 1 L·min-1·m-2....
Objective To investigate the electrophysiological characteristics of myocardium after hypothermic ischemia-reperfusion (I/R) in rats with different degrees arrhythmia using an vitro experiment. Methods Healthy clean-grade male Sprague-Dawley rats, aged 2-3 months, weighing 300-400 g, were used this study.The sacrificed anesthesia, and their hearts rapidly excised.Sixteen Langendorff-perfused prepared divided into 2 groups (n=8 each) by a random number table method: control group...
Objective To evaluate the effect of sevoflurane on phosphorylation connexin 43 (Cx43) at Ser368 (Cx43 Ser368) in ventricular myocardium isolated hearts diabetic rats. Methods Twenty-four clean-grade healthy adult male Sprague-Dawley rats, aged 3 months, weighing 180-220 g, were used this study.The model was established by intraperitoneally injecting streptozotocin 60 mg/kg.The rapidly excised and retrogradely perfused with K-H solution saturated 95% O2-5% CO2 37 ℃ a Langendorff...
Objective To evaluate the role of sarcolemmal ATP-sensitive potassium (sarcKATP) channel in sevoflurane-induced maintenance electrophysiological stability ventricular myocardium diabetic rats. Methods Clean-grade healthy male Sprague-Dawley rats, aged 3 months, weighing 280-320 g, which diabetes mellitus (DM) was induced by intraperitoneal streptozotocin 60 mg/kg and confirmed blood glucose ≥16.7 mmol/L, were used this study.Their hearts excised after anesthesia retrogradely perfused...
Objective To evaluate the electrophysiological changes of atrial myocardium in a rat model hypothermic ischemia-reperfusion (I/R). Methods Sixteen isolated Sprague-Dawley hearts successfully perfused Langendorff apparatus were divided into control group (group C) and I/R IR) using random number table method, with 8 heats each group.Heats IR further reperfusion-non-atrial arrhythmia subgroup R-NAA) reperfusion-atrial R-AA) depending on whether occurred after reperfusion.In C, heart was...