A5100338192- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ and Tissue Transplantation Research
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Polyomavirus and related diseases
- Lung Cancer Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Mycobacterium research and diagnosis
- Organ Donation and Transplantation
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Pleural and Pulmonary Diseases
- Respiratory viral infections research
- Pediatric Hepatobiliary Diseases and Treatments
Union Hospital
2022-2025
Huazhong University of Science and Technology
2020-2025
Wuxi People's Hospital
2016-2025
Nanjing Medical University
2016-2025
Second Affiliated Hospital of Zhejiang University
2011-2025
Southwest Jiaotong University
2023-2025
Children's Hospital of Chongqing Medical University
2012-2025
Chongqing Medical University
2015-2025
Sun Yat-sen University
2018-2025
Southern Medical University
2024-2025
Section:ChooseTop of pageAbstract <<Study DesignMethodsResultsDiscussionReferencesCITING ARTICLES
Abstract To identify microRNAs (miRNAs, miRs) with potential roles in lung fibrogenesis, we performed genome-wide profiling of miRNA expression tissues from a silica-induced mouse model pulmonary fibrosis using microarrays. Seventeen miRNAs were selected for validation via qRT-PCR based on the fold changes between silica and control group. The dysregulation five miRNAs, including miR-21, miR-455, miR-151-3p, miR-486-5p miR-3107, confirmed by qRT-PCRs also bleomycin (BLM)-induced fibrosis....
Rationale: Posttranscriptional modifications are implicated in vascular remodeling of pulmonary hypertension (PH). m6A (N6-methyladenosine) is an abundant RNA modification that involved various biological processes. Whether and effector proteins play a role PH has not been demonstrated.Objectives: To determine whether effectors contribute to the pathogenesis PH.Methods: YTHDF1 expression were measured human experimental samples. immunoprecipitation analysis sequencing employed screen...
Although numerous prognostic factors have been found for patients after lung transplantation (LTx) over the years, an accurate tool LTx recipients remains unavailable.To develop and validate a model predicting overall survival in using random forests (RSF), machine learning algorithm.This retrospective study included who underwent between January 2017 December 2020. The were randomly assigned to training test sets accordance with ratio of 7:3. Feature selection was performed variable...
Pulmonary hypertension (PH) is a devastating disease characterized by irreversible pulmonary vascular remodeling (PVR) that causes right ventricular failure and death. The early alternative activation of macrophages critical event in the development PVR PH, but underlying mechanisms remain elusive. Previously we have shown N6-methyladenosine (m6A) modifications RNA contribute to phenotypic switching artery smooth muscle cells PH. In current study, identify Ythdf2, an m6A reader, as important...
Background. Primary graft dysfunction, which is directly related to cold ischemia–reperfusion (CI/R) injury, a major obstacle in lung transplantation (LTx). Ferroptosis, novel mode of cell death elicited by iron-dependent lipid peroxidation, has been implicated ischemic events. This study aimed investigate the role ferroptosis LTx-CI/R injury and effectiveness liproxstatin-1 (Lip-1), inhibitor, alleviating injury. Methods. LTx-CI/R-induced signal pathway alterations, tissue death,...
Abstract Pulmonary fibrosis (PF) is a severe pulmonary disease with limited available therapeutic choices. Recent evidence increasingly points to abnormal lipid metabolism as critical factor in PF pathogenesis. Our latest research identifies the dysregulation of low-density lipoprotein (LDL) new risk for PF, contributing alveolar epithelial and endothelial cell damage, fibroblast activation. In this study, we first integrative summarize published literature about metabolite changes found...
Mitochondrial dysfunction is one of the hallmarks cardiovascular aging. The leakage mitochondrial DNA (mtDNA) increased in senescent cells, which are resistant to programmed cell death such as apoptosis. Due its similarity prokaryotic DNA, mtDNA could be recognized by cellular sensors and trigger innate immune responses, resulting chronic inflammatory conditions during mechanisms include cGAS-STING signaling, TLR-9 inflammasomes activation. quality controls mitophagy prevent mitochondria...
The mammalian target of rapamycin (mTOR) signaling pathway in pulmonary fibrosis was investigated cell and animal models. mTOR overactivation alveolar epithelial cells (AECs) achieved the conditional inducible Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1fx/+ (STT). Doxycycline caused consequently activation AECs for STT mice. Mice treated with bleomycin exhibited increased mortality compared control In wild-type C57BL/6J mice, pretreatment attenuated bleomycin-mediated fibrosis....
Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF characterized by excessive accumulation of the extracellular matrix (ECM) in alveolar parenchyma and progressive lung scarring. The pathogenesis whether ECM involved process remain unknown.To identify potential treatment target associated proteins that may be development IPF, we employed isobaric tag for relative absolute quantitation (iTRAQ) combined liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic erythematosus (SLE). However, neuropsychiatric manifestations in this have not been investigated detail. Because (NPSLE) an important complication of SLE, we the symptoms PIL mouse to evaluate its suitability NPSLE studies.PIL mice showed olfactory dysfunction accompanied by anxiety- and depression-like phenotype at month 2 or 4 after pristane injection. levels cytokines (IL-1β, IFN-α, IFN-β,...
Abstract Loss of refreshment in nucleus pulposus (NP) cellularity leads to intervertebral disc (IVD) degeneration. Nevertheless, the cellular sequence NP cell differentiation remains unclear, although an increasing body literature has identified markers progenitor cells (NPPCs). Notably, due their fragility, physical enrichment NP‐derived limited conventional transcriptomic approaches multiple studies. To overcome this limitation, a spatially resolved transcriptional atlas mouse IVD is...
The vestibular system may have a critical role in the integration of sensory information and maintenance cognitive function. A dysfunction has significant impact on quality life. Recent research provided evidence connection between functions, such as spatial memory, navigation attention. Although exact mechanisms linking to cognition remain elusive, researchers identified various pathways. Vestibular lead degeneration cortical network regions adversely affect synaptic plasticity neurogenesis...
This 3 year prospective study evaluated the sensitivity and specificity of abdominal ultrasonography color Doppler in 31 neonates with suspected malrotation or volvulus. Water instillation was used to detect duodenal dilatation, edema, malrotated bowels. Twenty patients ultrasonographic characteristics inversion superior mesenteric artery vein were later surgically proved have malrotation. Nine these 20 also had Sonographic features suggestive volvulus included dilation tapering...
BACKGROUNDLevonorgestrel (LNG), as a dedicated emergency contraception (EC) product, has been available over-the-counter in China for 10 years. Until now, only small number of deliveries after LNG–EC failure have documented.
Proliferation of vascular smooth muscle cells (VSMCs) greatly contributes to remodeling in hypertension. This study is determine the roles and mechanisms miR-135a-5p intervention attenuating VSMC proliferation spontaneously hypertensive rats (SHRs). MiR-135a-5p level was raised, while fibronectin type III domain-containing 5 (FNDC5) mRNA protein expressions were reduced VSMCs SHRs compared with those Wistar-Kyoto (WKYs). Enhanced inhibited by knockdown or inhibitor, but exacerbated mimic....
Abstract The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. induces several biosynthetic programmes primary overexpressing are highly sensitive glutamine withdrawal suggesting that MYC-induced sensitisation apoptosis may be due imbalance metabolic/energetic supply demand. Here we show elevates global transcription translation, even in the absence glutamine, revealing metabolic demand without...
T cell receptor (TCR)-engineered therapy is a promising potential treatment for solid tumors, with preliminary efficacy demonstrated in clinical trials. However, obtaining clinically effective TCR molecules remains major challenge. We have developed strategy cloning tumor-specific TCRs from long-term surviving patients who responded to immunotherapy. Here, we report the identification of (10F04), which human leukocyte antigen (HLA)-DRA/DRB1*09:01 restricted and papillomavirus type 18 (HPV18) E7