A5019056704- Pediatric Hepatobiliary Diseases and Treatments
- Semiconductor materials and devices
- Congenital Anomalies and Fetal Surgery
- Gallbladder and Bile Duct Disorders
- Systemic Sclerosis and Related Diseases
- Congenital gastrointestinal and neural anomalies
- Intestinal Malrotation and Obstruction Disorders
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Plasma Diagnostics and Applications
- Pancreatic and Hepatic Oncology Research
- High Altitude and Hypoxia
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Spaceflight effects on biology
- GaN-based semiconductor devices and materials
- Photonic and Optical Devices
- Tracheal and airway disorders
- Ion-surface interactions and analysis
- Metal and Thin Film Mechanics
- Silicon Nanostructures and Photoluminescence
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Genetic Associations and Epidemiology
Beijing Children’s Hospital
2023-2025
Capital Medical University
2023-2025
Center for Children
2024
Fudan University
1988-2024
State Key Laboratory of Genetic Engineering
2019-2023
State Grid Corporation of China (China)
2018
Wenzhou Medical University
2015-2016
Hohai University
2012
Shenyang Agricultural University
2010
Huashan Hospital
2005
Respiratory chain complexes are organized into large supercomplexes among which supercomplex In + IIIn IVn is the only one that can directly transfer electrons from NADH to oxygen. Recently, it was reported formation of in mice largely depends on their genetic background. However, this study, we showed composition well conserved various mouse and human cell lines. Strikingly, found a minimal IIIn, termed “lowest supercomplex” (LSC) study because its migration at lowest position close complex...
Cholangitis following the Kasai procedure contributes to a poor prognosis in biliary atresia (BA). We report case of pediatric patient with BA who developed recurrent cholangitis after undergoing and was subsequently found carry mitochondrial DNA (mtDNA) 3243 A>G mutation. This involves 7-month-old female infant who, at 2 months age, exhibited symptoms including jaundice, stool discoloration, dark urine, prompting diagnosis hyperbilirubinemia. Hepatobiliary dynamic imaging suggested BA,...
ABSTRACT Importance Early diagnosis of biliary atresia (BA) is important for advancing the Kasai operation time and improving BA prognosis. Objective To develop machine learning (ML) models neonatal using clinical characteristics serological data. Methods Neonates presenting with pathological jaundice between January 1, 2013, December 31, 2023 were enrolled. Five ML models—logistic regression (LR), random forest (RF), support vector classifier (SVC), multilayer perceptron (MLP), extreme...
The aim of this study was to evaluate the contribution mitochondrial DNA (mtDNA) mutations in oxidative phosphorylation (OXPHOS) deficiency. complete genomes 41 families with OXPHOS deficiency were screened for mutations. Mitochondrial functional analysis then performed primary and cybrid cells containing candidate identified during screening. A novel NADH dehydrogenase 5 (ND5) m.12955A > G mutation a patient exercise intolerance developmental delay. biochemical revealed deficiencies...
Background and aimsGallstone disease (cholelithiasis) is a cholesterol-related metabolic disorders with strong familial predisposition. Mitochondrial DNA (mtDNA) variants accumulated during human evolution are associated some related to modified mitochondrial function. The mechanistic links between mtDNA gallstone formation need further exploration.MethodsIn this study, we explored the possible associations of by comparing 104 probands 300 controls in Chinese population. We constructed...
Innate immunity significantly contributes to SSc pathogenesis. TLR8 is an important innate immune mediator that implicated in autoimmunity and fibrosis. However, the expression, mechanism of action, pathogenic role remain unclear. The aim this study was explore roles underlying mechanisms SSc.
Purpose: This study aimed to quantify the different quadrants of optic nerve head (ONH) and macular parameters their changes during exposure high altitude, assess correlation with high-altitude headache (HAH). Methods: Spectral-domain optical coherence tomography (OCT) was used in retinal structure 109 healthy subjects acute altitude (3,700 m). Self-reported symptoms HAH mountain sickness AMS were assessed using Lake Louise Score (LLS), alongside measurements physiological (oxygen saturation...
As the proportion of renewable energy installations in modern power systems increases, major weather events can easily trigger significant fluctuations new generation and electricity load, presenting system with dual challenges ensuring supply consumption. Traditional dispatch models need more coordination optimization flexible resources under risk management operations. This study focuses on provincial-level transmission systems, aiming to achieve coordinated optimized across multiple time...
Recurrent tracheoesophageal fistula (rTEF) is a rare complication following initial esophageal atresia (EA) surgical repair, posing challenges in localization the during surgery due to severe thoracic adhesions and structural ambiguity from previous operations. We introduced two new methods for rTEF patients aimed compare impact of using these techniques versus not them on outcomes patients. retrospectively analyzed clinical data cases that underwent thoracoscopic repair at our hospital...
We report high power and efficiency operation of a vertical cavity surface emitting GaAs laser in an external cavity. The maximum cw output from the fundamental TEM00 mode was 700 mW at temperature 77 K when pumped by krypton-ion with 1.8 W pump power. obtained absolute quantum (pump photons to lasing photons) 44%, differential above threshold 58%.
With the development of MEMS technology, measurement and determination many sensitive parameters have been realized, interconnection between intelligent sensor network everything has become possible in hardware.Various integrated information sensing technologies also made great progress based on this.So, we can construct an system multi-sensor apply it to various fields, thus making kinds applications.This paper discusses studies application fusion fire warning firefighting system.
Mitochondrial DNA (mtDNA) haplogroups have been associated with functional impairments (i.e., decreased gait speed and grip strength, frailty), which are risk factors of disability. However, the association between mtDNA ADL disability is still unclear. In this study, we conducted an investigation 25 mtSNPs defining 17 major for in aging Chinese population. We found that haplogroup M7 was increased (OR = 3.18 [95% CI 1.29–7.83], P 0.012). The survival rate group (6.1%) lower than non-M7...
Stable isotope 13C-labelled phenylalanine breath test has been applied to enable the quantitative evaluation of hepatic functional reserve, but mechanism underlying changes in function not resolved. This study evaluated correlation between expression mRNA key enzymes mediating metabolism and L-[1-13C] (13C-phe) assessed by excretion 13C-CO2 rats with, without, chronic injury induced administration carbon tetrachloride (CCl4).Male Sprague-Dawley (SD) (n = 29) were given subcutaneous...
Vertical-cavity surface-emitting la- sers (VCSELs) have come a long way in the past decade, evolving from laboratory curiosity to key component fiber-optic communications local area networks (LANs). Rapid advances are reported 1.5-1.6-µm wavelength VCSELs with tunability and long-reach single-mode fiber transmission. With proven cost benefits LAN applications, poised meet rising market demands of metropolitan applications.
Abstract Metabolic disorders (MDs) are a group of medical conditions that impact the metabolism. These complex processes may have common characteristics among various diseases, thereby suggesting potential drug repurposing. Employing Mendelian Randomization (MR), we constructed causal network between 2,478 targetable drug-gene expressions (eQTLs) and 30 broadly reported metabolic disorders. Our study identified 499 target genes significantly associated with 27 (|MR coefficient| > 0.2)....
<h3>Background</h3> The Global Burden of Diseases study indicates that digestive system disorders are identified as high morbidity and burden diseases.The human proteome serves a primary source therapeutic targets for disease treatment, with its genetic association analysis (pQTL) enabling the systematic evaluation causal consequences plasma protein level variations on disorders. <h3>Methods</h3> We conducted Mendelian randomization (MR) analyses 47 using data from FinnGen cohort, followed...