A5068686283- Genetic and rare skin diseases.
- Skin and Cellular Biology Research
- Dermatological and Skeletal Disorders
- Spondyloarthritis Studies and Treatments
- Hedgehog Signaling Pathway Studies
- Extracellular vesicles in disease
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Cancer Genomics and Diagnostics
- Emotion and Mood Recognition
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- Cleft Lip and Palate Research
- Social Robot Interaction and HRI
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Face recognition and analysis
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Trace Elements in Health
- Genomics, phytochemicals, and oxidative stress
- Gout, Hyperuricemia, Uric Acid
- Bone Metabolism and Diseases
- Microbial Fuel Cells and Bioremediation
- DNA and Biological Computing
Tianjin University of Science and Technology
2025
Chinese National Human Genome Center
2004-2024
Chinese National Human Genome Center at Shanghai
2008-2024
Shanghai Academy of Science & Technology
2019-2024
Shanghai Public Health Clinical Center
2022
Shanghai Industrial Technology Institute
2015-2021
Zhengzhou City Hospital
2020
Fudan University
2015
State Key Laboratory of Genetic Engineering
2015
First Affiliated Hospital of Henan University of Science and Technology
2012
For efficient and high-fidelity local facial attribute editing, most existing editing methods either require additional fine-tuning for different effects or tend to affect beyond the regions. Alternatively, inpainting can edit target image region while preserving external areas. However, current still suffer from generation misalignment with attributes description loss of skin details. To address these challenges, (i) a novel data utilization strategy is introduced construct datasets...
Abstract Oculopharyngodistal myopathy is a late-onset degenerative muscle disorder characterized by ptosis and weakness of the facial, pharyngeal, distal limb muscles. A recent report suggested non-coding trinucleotide repeat expansion in LRP12 to be associated with disease. Here we genetic study Chinese cohort 41 patients clinical diagnosis oculopharyngodistal (21 cases from seven families 20 sporadic cases). In large family 12 affected individuals, combined haplotype linkage analysis...
Background Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic disorder of keratinization, characterized by multiple keratotic lesions surrounded a slightly raised border. Thus far, although two loci for DSAP have been identified, and the genetic basis pathogenesis this not elucidated. Objectives To determine locus identify candidate gene(s) disease. Methods Genome-wide scan linkage analysis were performed in six-generation Chinese family with...
Common polymorphisms of microRNA gene MIR146A were reported as associated with different autoimmune diseases, include systemic lupus erythematosus, psoriatic arthritis, asthma and ankylosing spondylitis. In this study we investigated SNPs in Chinese people Three common SNPs: rs2910164, rs2431697 rs57095329 selected genotyped 611 patients 617 controls. We found no association between these spondylitis our samples.
Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic keratinization disorder, characterized by multiple keratotic lesions surrounded a slightly raised border. Thus far, although two loci for DSAP have been identified, the genetic basis and pathogenesis of this disorder not elucidated yet. In study, we performed genome-wide linkage analysis in three Chinese affected families localized gene 8.0 cM interval defined D12S330 D12S354 on chromosome 12....
Proteasome is a large protein complex, which degrades most intracellular proteins. It regulates numerous cellular processes, including the removal of misfolded or unfolded proteins, cell cycle control, and regulation apoptosis. However, function proteasome subunits in viral immunity has not been well characterized. In this study, we identified PSMB1, member β (PSMB) family, as negative regulator innate immune responses during infection. Knockdown PSMB1 enhanced RNA virus-induced cytokine...
Background and aimsGallstone disease (cholelithiasis) is a cholesterol-related metabolic disorders with strong familial predisposition. Mitochondrial DNA (mtDNA) variants accumulated during human evolution are associated some related to modified mitochondrial function. The mechanistic links between mtDNA gallstone formation need further exploration.MethodsIn this study, we explored the possible associations of by comparing 104 probands 300 controls in Chinese population. We constructed...
Porokeratosis (PK) represents a heterogeneous group of disorders keratinization and has wide variety clinical manifestations. PK may exhibit similarities with psoriasis at both molecular levels. The genetic basis pathogenesis for remain elusive.We studied the transcriptional profiles three pairwise lesional uninvolved skin biopsies from patients different subtypes using Illumina BeadArray platform.A total 37 upregulated genes were identified in our study, including wound-induced keratins,...
<i>Background:</i> Psoriasis is a cutaneous disorder of multifactorial etiology influenced by both genetic and environmental factors such as infection. <i>Methods:</i> We conducted genome analysis with 20 microsatellite markers spanning the long arm chromosome 1 in 36 Chinese families psoriasis detected evidence for linkage at 1q21 nonparametric score 1.74, p = 0.03, 1q32 one 1.84, 0.03. According to positional functional candidate principle, we further investigated...
Gallstone disease (GD) is a common of multigenetic origin; however, the major susceptibility loci for GD in human populations remain unidentified. This study aimed to identify genetic factors contributing gallstone development Chinese.A genome-wide scan was conducted 12 Han Chinese families linkage loci. The region showing highest logarithm odds score encompasses sterol 12α-hydroxylase gene (CYP8B1). Replication analysis with an independent sample 192 patients and unrelated, matched controls...
Abstract Objective To explore whether the variants in non MHC proteasome gene are associated with AS and explain role of variant disease. Material methods Case-control analysis to identify predisposition genes; dual-luciferase reporter assay, immunoblot osteoclastogenesis assays detect function positive variant. Affected individuals were diagnosed according modified New York Criteria by at least two experienced rheumatologists, rechecked another rheumatologist. Results The study included...