A5100648305- Psoriasis: Treatment and Pathogenesis
- Genetic and rare skin diseases.
- Mitochondrial Function and Pathology
- Phytochemistry and Bioactivity Studies
- Evolution and Paleontology Studies
- Genetics, Aging, and Longevity in Model Organisms
- Natural product bioactivities and synthesis
- Dermatological and Skeletal Disorders
- Ginseng Biological Effects and Applications
- Skin and Cellular Biology Research
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Retinoids in leukemia and cellular processes
- Acute Lymphoblastic Leukemia research
- Rheumatoid Arthritis Research and Therapies
- RNA regulation and disease
- Phytochemistry and Bioactive Compounds
- Autoimmune and Inflammatory Disorders Research
- Skin Protection and Aging
- Phytochemistry and Biological Activities
- Dermatologic Treatments and Research
- Ginger and Zingiberaceae research
- Lung Cancer Diagnosis and Treatment
- Immune Response and Inflammation
University of Rochester
2021-2025
Huashan Hospital
2011-2024
Fudan University
2009-2024
Zhangzhou Municipal Hospital of Fujian Province
2024
Fujian Medical University
2018-2024
Fujian Institute of Subtropical Botany
2010-2024
Lanzhou University
2022-2024
Lanzhou University Second Hospital
2022-2024
Albert Einstein College of Medicine
2023
Weatherford College
2023
Porokeratosis (PK) is a heterogeneous group of keratinization disorders. No causal genes except MVK have been identified, even though the disease was linked to several genomic loci. Here, we performed massively parallel sequencing and exonic CNV screening 12 isoprenoid in 134 index PK patients (61 familial 73 sporadic) identified mutations three novel ( PMVK , MVD FDPS ) addition mevalonate pathway. Allelic expression imbalance (AEI) assays were 13 lesional tissues. At least one mutation...
Abstract At over 200 years, the maximum lifespan of bowhead whale exceeds that all other mammals. The is also second-largest animal on Earth, reaching 80,000 kg 1 . Despite its very large number cells and long lifespan, not highly cancer-prone, an incongruity termed Peto’s Paradox 2 This phenomenon has been explained by evolution additional tumor suppressor genes in larger animals, supported research elephants demonstrating expansion p53 gene 3–5 Here we show fibroblasts undergo oncogenic...
Abstract Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell migration, cancer. The naked mole-rat ( Heterocephalus glaber ) contains abundant high-molecular-mass hyaluronic its tissues, contributes this species’ cancer resistance possibly longevity. Here we report that found wide range subterranean mammalian species, but not phylogenetically related aboveground species. These species...
Hepatocellular carcinoma (HCC) is one of most common types malignant tumours. Therefore, it very important to identify powerful drugs and their antitumour mechanisms. Corilagin has a significant potential lower toxicity in normal cells vitro. The IC50 values corilagin for Chang-liver the HCC cell lines Bel7402 SMMC7721 were 131.4, 24.5 23.4 µM, respectively, methyl thiazolyl tetrazolium (MTT) assay. MHCC97-H xenografts Balb/c mice intraperitoneally injected with 30 mg/kg 5 weeks showed 47.3%...
This is the first well-controlled study of use botulinum toxin type A (BoNTA) for glabellar lines in China.To evaluate safety and efficacy BoNTA treatment Chinese subjects.A total 227 subjects received a single 3:1 randomization ratio (20 U):placebo were observed 120 days after injection. Effective outcome measures included investigator's rating wrinkle severity at maximum frown rest subjects' global assessment self-perception age.A significantly higher responder rate frown, ranging from...
Corilagin is a natural plant polyphenol tannic acid with antitumor, anti-inflammatory, and anti-oxidative properties. However, the mechanisms of its actions are largely unknown. Our group reported that corilagin could induce cell inhibition in human breast cancer line MCF-7 liver hepatocellular carcinoma lines HepG2. We report here inhibits cholangiocarcinoma (CCA) development through regulating Notch signaling pathway. found that, vitro, inhibited CCA proliferation, migration invasion,...
The present study was performed in order to define the clinical manifestations of porokeratosis, with particular emphasis on genital porokeratosis. A total 55 cases porokeratosis were retrospectively reviewed between 2000 and 2007 from Huashan Hospital (Shanghai, China). Out cases, there 22 Mibelli, 17 disseminated superficial actinic (DSAP), 15 one case linear ratio males females 39:16. Among them, 12 had a family history During five‑year follow‑up period, no malignant transformation...
Corilagin, a gallotannin, is one of the major active components many ethnopharmacological plants and exhibits antitumor, anti-inflammatory antioxidative properties. In recent years, corilagin has provoked much attention due to its antitumor activity, yet mechanisms attributed anticancer actions are largely unknown. our previous research, group reported that could inhibit proliferation hepatocellular carcinoma (HCC) cells by inducing G2/M phase arrest. present study, observation morphological...
It is necessary to determine whether psoriasis responds methotrexate in the same manner patients with and without psoriatic arthritis.To evaluate effectiveness safety of treating arthritis.In this prospective, single-arm, interventional study, a total 235 psoriasis, 107 arthritis 128 who were receiving therapy from April 1, 2015, December 31, 2017, recruited outpatient department hospital at large Chinese university. There no significant demographic or clinical differences between subgroups...
Abstract Background Naked mole-rats ( Heterocephalus glaber , NMRs) and blind Spalax galili BMRs) are representative subterranean rodents that have evolved many extraordinary traits, including hypoxia tolerance, longevity, cancer resistance. Although multiple candidate loci responsible for these traits been uncovered by genomic studies, of them limited to functional changes amino acid sequence little is known about the contributions other genetic events. To address this issue, we focused on...
SIRT6 is a protein deacylase, deacetylase, and mono-ADP-ribosylase (mADPr) regulating biological pathways important for longevity including DNA repair silencing of LINE1 retrotransposons. knockout mice die by 30 days age, whereas overexpression increases lifespan in male mice. Finding safe pharmacological activators would have clinical benefits. Fucoidan, polysaccharide purified from brown seaweed, has been identified as an activator deacetylation activity. Here, we show that fucoidan also...
Several bat species live >20-40 years, suggesting that they possess efficient anti-aging and anti-cancer defenses. Here we investigate the requirements for malignant transformation in primary fibroblasts from four Myotis lucifugus, Eptesicus fuscus, Eonycteris spelaea, Artibeus jamaicensis - spanning evolutionary tree including longest-lived genera. We show do not undergo replicative senescence, express active telomerase, attenuated SIPs with dampened secretory phenotype. Unexpectedly,...
Background Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic disorder of keratinization, characterized by multiple keratotic lesions surrounded a slightly raised border. Thus far, although two loci for DSAP have been identified, and the genetic basis pathogenesis this not elucidated. Objectives To determine locus identify candidate gene(s) disease. Methods Genome-wide scan linkage analysis were performed in six-generation Chinese family with...
The intestinal metabolite of ginseng saponin, compound K (CK), has various chemopreventive and chemotherapeutic activities, including anti-tumor activity. However, the functional mechanisms through which CK attenuates metastatic growth in hepatocellular carcinoma (HCC) remain unclear. Here, using multiple IN VITRO VIVO models, we reported that strongly attenuated colony formation, adhesion, invasion HCC cells dramatically inhibited spontaneous VIVO. At molecular level, immunofluorescence...
Phyllanthus niruri L., a well-known medicinal plant, has been used as folk antitumor remedy in the worldwide scale. However, components P. have not reported. In order to verify of and plants which high content these components, we isolated with bioguided fraction isolation, by different chromatographic methods from ethyl acetate niruri. , identified them brevifolincarboxylate corilagin 1 H-NMR, 13 C-NMR, 2D-NMR, mass spectrometric analyses. Cell cytotoxicity assays showed that broad-spectrum...
The evolutionary outcomes of high elevation adaptation have been extensively described. However, whether widely distributed endemic animals adopt uniform mechanisms during to different elevational environments remains unknown, especially with respect extreme environments. To explore this, we analysed the phenotypic and genomic data seven populations plateau zokor (Myospalax baileyi) along elevations ranging from 2,700 4,300 m. Based on whole-genome sequencing demographic reconstruction...
Abstract Background Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear. Objective To investigate of MTX on lipid profiles and difference between psoriasis without arthritis (PsO) psoriatic (PsA). Methods In this prospective study, we recruited 288 patients (136 PsA 152 PsO) who completed 12 weeks treatment. Total cholesterol (TC), triglycerides (TG), lipoprotein A [LP(a)], high-density (HDL-C), low-density (LDL), apolipoprotein A1...
Abstract Background Noninvasive energy‐based device (NI‐EBD) aesthetic procedures has recently gained widespread usage for treating various skin conditions, enhancing texture and performing rejuvenation‐related procedures. However, practically all NI‐EBD result in variable degrees of damage to the barrier, inducing pathological physiological processes such as oxidative stress inflammation, only a small percentage individuals possess innate ability restore it. Objective To introduce concept...
20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol (IH-901), a novel intestinal bacterial metabolite of ginseng protopanaxadiol saponins, is reported to induce apoptosis in variety cancer cells. We purified the compound and measured its vitro anti-tumor activity. IH-901 inhibited cell growth human hepatocellular carcinoma SMMC7721 cells dose- time-dependent manner. also found that induced apoptotic death concurrent with cycle arrest G0-G1 phase At molecular level, we show upregulates...