A5101992698- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Body Composition Measurement Techniques
- Thermal Regulation in Medicine
- Diagnosis and Treatment of Venous Diseases
- Contact Dermatitis and Allergies
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Facial Rejuvenation and Surgery Techniques
- Infection Control and Ventilation
- Skin and Cellular Biology Research
- melanin and skin pigmentation
- Food Allergy and Anaphylaxis Research
- Botulinum Toxin and Related Neurological Disorders
- Occupational exposure and asthma
- Autophagy in Disease and Therapy
- Drug-Induced Adverse Reactions
- Hair Growth and Disorders
- Retinal and Optic Conditions
- Venous Thromboembolism Diagnosis and Management
- Urticaria and Related Conditions
- Sympathectomy and Hyperhidrosis Treatments
- Dermatology and Skin Diseases
- Myofascial pain diagnosis and treatment
- Hidradenitis Suppurativa and Treatments
Peking University First Hospital
2006-2024
National Medical Products Administration
2022-2024
Peking University
2006-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Medical University of Vienna
2014-2023
Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin mucous membrane injury, which may cause acute chronic dermatitis, secondary infection aggravation of underlying diseases. This is a consensus Chinese experts on protective measures advice hand-cleaning- medical-glove-related hand protection, mask- goggles-related face UV-related eye nasal oral mucosa outer ear, hair protection. It necessary strictly follow standards wearing equipment specification...
Antimicrobial peptides (AMPs), an important part of the innate immune system, are crucial for defense against invading microorganisms. Whereas AMPs have been extensively studied in adult skin, little is known about impact developing human skin. We therefore compared expression and regulation fetal, neonatal, keratinocytes (KCs) vitro. The constitutive β-defensin-2 (HBD-2), HBD-3, S100 protein family members, cathelicidin was significantly higher KCs from fetal skin than postnatal capacity to...
This is the first well-controlled study of use botulinum toxin type A (BoNTA) for glabellar lines in China.To evaluate safety and efficacy BoNTA treatment Chinese subjects.A total 227 subjects received a single 3:1 randomization ratio (20 U):placebo were observed 120 days after injection. Effective outcome measures included investigator's rating wrinkle severity at maximum frown rest subjects' global assessment self-perception age.A significantly higher responder rate frown, ranging from...
Objective: To obtain potential skin whitening agents from traditional Chinese herbs, we tested changes of melanin content in melanocyte cell lines after treatment with extracts 90 herbs. Methods: Mouse were used. Depigmentation activity the herb first screened Mel-Ab cells, and then re-evaluated melan-a cells co-culture SP-1 cells. Melanin viability two indications for evaluation. Tyrosinase expression synthesis related enzymes treated also tested. Results: Nine proved to have depigmentation...
The aim of the present study was to evaluate efficacy and safety lignin peroxidase (LIP) as a skin-lightening agent in patients with melasma. A self-controlled clinical performed 31 women who had melasma on both sides face. This involved 8 weeks full-face product treatment. skin color measured at days 0, 7, 28 56 using chromameter forehead cheeks. Standardized digital photographic images each side face all subjects were captured by complexion analysis system. Clinical scores pigmentation...
Epidermal keratinocytes undergo cornification to form the cellular building blocks of hard skin appendages such as nails and protective layer on surface skin. Cornification requires cross-linking structural proteins removal other components mechanically rigid inert corneocytes. Autophagy has been proposed contribute this intracellular remodelling process, but its molecular targets in keratinocytes, if any, have remained elusive. Here, we deleted essential autophagy factor Atg7 K14-positive...
Two new compounds, cinnamic aldehyde cyclic d-galactitol 3′R,4′S-acetal (1) and cinnamomumolide (2), along with six known syringaresinol (3), lyoniresinol (4), 5,7,3′-trimethoxyl-( − )-epicatechin (5), 5,7-dimethoxyl-3′,4′-di-O-methylene-( ± (6), 2-methoxyl-4-hydroxy cinnamyl (7), glucosyringic acid (8), have been isolated from the dried tender stems of Cinnamomum cassia. Their structures were elucidated based on spectroscopic data. Compound 2 was as...
Abstract Background Patients are increasingly aware of the aesthetic appearance aging hands. Aims To evaluate efficacy and safety a hyaluronic acid gel for improving skin quality in aged dorsal hand. Methods This was 15‐month randomized, multi‐center, evaluator‐blinded, split‐hand, no treatment‐controlled study. Three treatments with were administered same hand adult Chinese subjects grade 2 or 3 (mild moderate aging) on Hand Grading Scale (HGS). The primary objective to difference at months...
Injection of cross-linked hyaluronic acid (CLHA) has been traditionally utilized to treat wrinkles and provide volume. Recent studies have also shown that intradermal placement CLHA provides lasting secondary effects may be a useful method for improving skin appearance physiology.The aim this study was investigate the biostimulatory potential underlying mechanisms induced by repeated microinjections small-particle (SPCLHA) rejuvenation.Eight patients with photoaged forearm underwent three...
Botulinum toxin has been widely accepted as safe and effective for the treatment of glabellar lines, previous studies have classified contraction patterns into 5 categories.To classify among a large-scale Chinese population provide reference injections in patients.Four hundred eighty-nine subjects who received botulinum lines were selected retrospective photographic analysis their patterns. Using 2 separate previously established classification systems, analyzed by panel certified...
The chin is an important component of facial harmony, and deficient chins are associated with unattractiveness. Previous studies have reported microgenia as the most common subtype deformities.To investigate prevalence severity in a Chinese population through anthropometric analysis.A total 800 Han adults from various age groups both sexes were recruited for measurements photographic analysis. Chin deficiencies sagittal vertical dimensions evaluated using G-S-P angle, retrusion distance,...
Mask-wearing behavior, common in the post-COVID-19 era, raises concerns for sensitive skin. This split-face study investigated mask-related changes skin barrier function and microbiome composition among 30 female volunteers with assessed mitigating effects of a moisturizer containing biological lipids probiotics. Skin physiological indicators (transepidermal water loss, erythema index, stratum corneum hydration, pH, temperature) masked unmasked areas were collected at baseline, after three...
Objective To investigate the effect of fusidic acid cream on inflammatory reaction caused by skin barrier damage.Methods Eight male SKH-1 hairless mice were included in this study.The back each these equally divided into six regions measuring 1 cm × 2 size,which then assigned groups:blank control group remaining untreated,barrier-impaired group,barrier-impaired and acid-treated vehicle-treated group,barrier-unimpaired group,barrierunimpaired group.Stratum corneum was removed adhesive tape...
A 61-year-old man presented with rapidly growing and itchy cutaneous nodules all over his body prominent lymphadenopathies. What is your diagnosis?
Objective To evaluate the inhibitory effect of butyl flufenamate（BT）on ultraviolet（UV）-induced acute skin phototoxic reaction, and to investigate its possible mechanisms. Methods Eight SKH-1 hairless mice were included in this study. The back each mouse was divided into six regions, which then randomly classified groups: blank group receiving no treatment, UV radiation only, BT + vehicle topically treated with ointment respectively followed by radiation, after radiation. Skin samples...