A5072861152- melanin and skin pigmentation
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Climate Change and Health Impacts
- Acne and Rosacea Treatments and Effects
- Thermoregulation and physiological responses
- Skin and Cellular Biology Research
- Genetic and rare skin diseases.
- Dermatological and Skeletal Disorders
- Body Composition Measurement Techniques
- Dermatology and Skin Diseases
- Thermal Regulation in Medicine
- Atherosclerosis and Cardiovascular Diseases
- Biochemical Analysis and Sensing Techniques
- Laser Applications in Dentistry and Medicine
- Contact Dermatitis and Allergies
- Cancer-related molecular mechanisms research
- Photodynamic Therapy Research Studies
- RNA regulation and disease
- Genomics, phytochemicals, and oxidative stress
- Autoimmune Bullous Skin Diseases
- Pharmacological Effects of Natural Compounds
- Food Allergy and Anaphylaxis Research
- Infection Control and Ventilation
- Retinal and Optic Conditions
Huashan Hospital
2016-2025
Fudan University
2016-2025
Zhejiang Cancer Hospital
2025
Creative Commons
2018-2023
Weatherford College
2023
Chengdu Second People's Hospital
2023
Shanghai Medical College of Fudan University
2005-2009
University of Hong Kong
2003
Jackson Memorial Hospital
1996
The pathogenesis of systemic lupus erythematosus (SLE) is multifactorial and multigenetic. apoptosis genes, fas ligand (fasL), are candidate contributory genes in human SLE, as mutations these result autoimmunity several murine models this disease. In humans, a familial autoimmune lymphoproliferative syndrome, but defects FasL have not yet been identified. study, DNA from 75 patients with SLE was screened by single-stranded conformational polymorphism analysis for potential the extracellular...
Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin mucous membrane injury, which may cause acute chronic dermatitis, secondary infection aggravation of underlying diseases. This is a consensus Chinese experts on protective measures advice hand-cleaning- medical-glove-related hand protection, mask- goggles-related face UV-related eye nasal oral mucosa outer ear, hair protection. It necessary strictly follow standards wearing equipment specification...
Abstract Autophagy is a process involving the self-digestion of components that participates in anti-oxidative stress responses and protects cells against oxidative damage. However, role autophagy melanocytes remains unclear. To investigate human epidermal melanocytes, we knocked down overexpressed ATG7, critical gene autophagy, normal melanocytes. We demonstrated ATG7-dependent could affect melanin content by regulating melanogenesis. Moreover, suppression inhibits proliferation promotes...
Abstract Objectives To analyze associations between the patterns of global DNA hypomethylation and expression methyltransferase (DNMT1, DNMT3A, DNMT3B) in patients with systemic lupus erythematosus (SLE) to obtain a deeper understanding role that epigenetic mechanism may have on SLE. Methods The methylation profile T cells from 34 SLE 23 healthy controls was assessed by specific monoclonal antibodies 5‐methylcytosine analyzed quantitatively flow cytometry. Real‐time reverse...
The present study was performed in order to define the clinical manifestations of porokeratosis, with particular emphasis on genital porokeratosis. A total 55 cases porokeratosis were retrospectively reviewed between 2000 and 2007 from Huashan Hospital (Shanghai, China). Out cases, there 22 Mibelli, 17 disseminated superficial actinic (DSAP), 15 one case linear ratio males females 39:16. Among them, 12 had a family history During five‑year follow‑up period, no malignant transformation...
It is necessary to determine whether established clinical markers of vitiligo are associated with disease progression, severity, and patient prognosis.To evaluate the utility trichrome sign, confetti-like depigmentation, Koebner phenomenon in assessing prognosis patients vitiligo.In this prospective cohort study, 425 were recruited from outpatient department Huashan Hospital, Fudan University Shanghai, China, September 1, 2016, May 13, 2019.Disease during a 12-month period. The active stage...
Acne is a common inflammatory skin disease, while cannabidiol (CBD) representative non-psychoactive phytocannabinoid which has been proved to exert universal anti-inflammatory properties. This study aimed explore the effect of CBD on acne inflammation induced by Cutibacterium acnes-derived extracellular vesicles (CEVs) in keratinocytes and reveal underlying mechanisms.Normal human epidermal (NHEKs) were stimulated CEVs presence or vehicle. Interleukin (IL)-6, IL-8, tumor necrosis factor...
ABSTRACT Background/Purpose Photobiomodulation (PBM) using light‐emitting diodes (LEDs) benefits tissue regeneration and wound healing. However, evidence regarding the efficacy of LED for post‐inflammatory erythema (PIE) hyperpigmentation (PIH) is limited. The aim this study was to explore effect medical (830 nm 590 nm) in prevention treatment PIE PIH. Methods vivo PIE/PIH model simplified pigmentation reaction after acute UVB exposure. 308 light (225 or 270 mJ/cm 2 ) induced on thigh ten...
Doxorubicin (DOX) is a well-established chemotherapy drug, but its clinical application restricted due to significant tissue toxicity, of which nephrotoxicity serious adverse reaction. Low-dose radiation (LDR) exerts effects through stimulating diverse cell and molecular mechanisms, has been shown have anti-inflammatory alter immune adaptation effects. This study aims investigate how LDR protects against DOX-induced explore the underlying mechanism involved. Sixty mice were randomly divided...