A5102808838- melanin and skin pigmentation
- Mitochondrial Function and Pathology
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- RNA and protein synthesis mechanisms
- ATP Synthase and ATPases Research
- Wound Healing and Treatments
- RNA regulation and disease
- Vasculitis and related conditions
- Electrospun Nanofibers in Biomedical Applications
- T-cell and B-cell Immunology
- Enzyme Production and Characterization
- Genomics and Phylogenetic Studies
- Metabolism and Genetic Disorders
- Atherosclerosis and Cardiovascular Diseases
- Hair Growth and Disorders
- Hydrogels: synthesis, properties, applications
- Urticaria and Related Conditions
- Cytomegalovirus and herpesvirus research
- Molecular Biology Techniques and Applications
- Enzyme Catalysis and Immobilization
- Heparin-Induced Thrombocytopenia and Thrombosis
- Dermatology and Skin Diseases
- Pressure Ulcer Prevention and Management
- Advanced Proteomics Techniques and Applications
Anhui Medical University
2008-2024
Second Hospital of Anhui Medical University
2019-2024
Anhui University
2011
Desorption electrospray ionization (DESI) mass spectrometry imaging (MSI) can simultaneously record the 2D distribution of polar biomolecules in tissue slices at ambient conditions. However, sensitivity DESI-MSI for nonpolar compounds is restricted by low efficiency and strong ion suppression. In this study, a compact postphotoionization assembly combined with DESI (DESI/PI) was developed molecules sections switching off/on portable krypton lamp. Compared DESI, higher signal intensities...
Gentamicin as a physical crosslinker endowed the supramolecular poly(TA) hydrogel with better self-healing, strong adhesion, and persistent antibacterial properties.
Laser-based high-resolution mass spectrometry imaging at ambient conditions has promising applications in life science. However, the ion yield during laser desorption/ablation is poor. Here, transmission atmospheric pressure desorption ionization combined with a compact postphotoionization (t-AP-LDI/PI) assembly krypton discharge lamp was developed for untargeted of various biomolecules. The spatial distributions numerous lipid classes, fatty acids, neurotransmitters, and amino acids...
Licochalcone A (LCA) was found to possess anticancer effects. This study aimed investigate the effects and mechanisms of LCA in melanoma. A375 B16 melanoma cells were stimulated with LCA, MTT assay used assess cell proliferation. Expression miR‐142‐3p, microphthalmia‐associated transcription factor (MITF, which regulates melanin production) autophagy‐related genes determined by Real‐time PCR or western blot. The apoptosis analyzed flow cytometry caspase‐3 activity. roles miR‐142‐3p Ras...
Alopecia areata (AA) is an autoimmune disorder and chronic recurrent inflammatory disease that results in non-scarring hair loss.Our aim to investigate several parameters related autoimmunity inflammation AA patients evaluate their association with this disease.This study included a total of 672 eligible 580 age- sex-matched healthy individuals who were treated at third-class hospital Hefei from January 2016 May 2020. Data for serum C-reactive protein (CRP), 25-hydroxy vitamin D (25(OH)D),...
Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disease. Clinically, no efficient assay protocols have been available. In this study, we aimed to develop an oligonucleotide biochip specialized for detection of known base substitution mutations in mitochondrial DNA causing LHON and investigate frequencies relevant variants Anhui region China. Thirty-two pairs probes matched with the potentially linked were covalently immobilized. Cy5-lablled targets amplified from blood...
Two putative α-D-galactosidases (α-GALs) belonging to glycosyl hydrolase family 27, and originating from the rather unexplored bacterial strain Pedobacter heparinus, were cloned biochemically characterized. The recombinant enzymes designated as PhAGal729 PhAGal2920 showed comparable biochemical properties: optimum pH values determined be 5.0 5.5, temperature optima lay between 30°C 37°C, respectively. Both α-GALs not dependent on presence of divalent metal ions, addition EDTA had no...
Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disease. Clinically, no efficient assay protocols have been available. In this study, we aimed to develop an oligonucleotide biochip specialized for detection of known base substitution mutations in mitochondrial DNA causing LHON and investigate frequencies relevant variants Anhui region China. Thirty-two pairs probes matched with the potentially linked were covalently immobilized. Cy5-lablled targets amplified from blood...
Background: To understand the distribution of onset time, age onset, and gender IgAV patients admitted to our hospital, analyze differences similarities between minors adults. Methods: The clinical data 2721 with including adults a tertiary hospital in Hefei fromJanuary 2009 December 2022 were collected analyzed retrospectively.Results: Among cases, 53.4% (<18 years old), 46.6% (≥18 old).The disease peak occurred aged 5-9 years, while adults, there more young people 18-30.The male-to-female...