A5049703242- Fungal Plant Pathogen Control
- Synthesis of Organic Compounds
- Advanced Decision-Making Techniques
- Synthesis and biological activity
- Sesquiterpenes and Asteraceae Studies
- Synthesis and Biological Evaluation
- Risk and Safety Analysis
- Evaluation Methods in Various Fields
- Bioactive Compounds and Antitumor Agents
- Plant-Microbe Interactions and Immunity
- Luminescence Properties of Advanced Materials
- Evaluation and Optimization Models
- Natural Compounds in Disease Treatment
- Pain Mechanisms and Treatments
- Plant Disease Resistance and Genetics
- Natural product bioactivities and synthesis
- Perovskite Materials and Applications
- Connexins and lens biology
- Multicomponent Synthesis of Heterocycles
- Phytochemical compounds biological activities
- Reliability and Maintenance Optimization
- Skin and Cellular Biology Research
- Aquaculture disease management and microbiota
- Axial and Atropisomeric Chirality Synthesis
- Immunotherapy and Immune Responses
Lanzhou University
2023-2024
Lanzhou University Second Hospital
2023-2024
China Railway Design Corporation (China)
2023-2024
Anhui Medical University
2004-2023
Shanghai University of Traditional Chinese Medicine
2022-2023
First Affiliated Hospital of Anhui Medical University
2004-2023
Yueyang Hospital
2022-2023
Ministry of Education of the People's Republic of China
2013-2023
Northwest A&F University
2006-2022
Daqing Oilfield General Hospital
2022
Background We explore sphingolipid-related genes (SRGs) in skin melanoma (SKCM) to develop a prognostic indicator for patient outcomes. Dysregulated lipid metabolism is linked aggressive behavior various cancers, including SKCM. However, the exact role and mechanism of sphingolipid remain partially understood. Methods integrated scRNA-seq data from patients sourced GEO database. Through utilization Seurat R package, we successfully identified distinct gene clusters associated with survival...
Neuropathic pain is a common syndrome, which seriously affects the quality of life patients. The mechanism neuropathic complex. Peripheral tissue injury can trigger peripheral sensitization; however, what really plays key role sensitization central nervous system. Central factor in perception chronic pain. refers to increased sensitivity system treatment, related change functional connection mode neural network. current study aims reveal basic molecular mechanisms sensitization, including...
The first organocatalytic enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes for the direct synthesis chiral nitroalkylated naphthoquinone derivatives was investigated. Good yields and excellent enantioselectivities (up >99% ee) could be achieved. This asymmetric provides an efficient route torward optically active functionalized naphthoquinones.
Five new sesquiterpene polyol esters were isolated from the root bark of Celastrus angulatus by bioassay-guided fractionation. Their structures determined spectral data interpretation as 1alpha,2alpha,6beta,8beta,13-pentaacetoxy-9beta-benzoyloxy-4beta-hydroxy-beta-dihydroagarofuran (1), 1alpha,2alpha,6beta-triacetoxy-8alpha-(beta-furancarbonyloxy)-9beta-benzoyloxy-13-isobutanoyloxy-4beta-hydroxy-beta-dihydroagarofuran (2),...
A synthesis of the 6-5-5 tricyclic skeleton diterpenoid aberrarone is reported. The strategically features an intermolecular Diels-Alder reaction to construct cis-hydrindane moiety and a cross coupling-isomerization-intramolecular...
Road extraction is a typical task in the semantic segmentation of remote sensing images, and one most efficient techniques for solving this recent years vision transformer technique. However, roads typically exhibit features such as uneven scales low signal-to-noise ratios, which can be understood asymmetry between road background category transverse longitudinal shape road. Existing models, due to their fixed sliding window mechanism, cannot adapt scale issue roads. Additionally,...
Six sesquiterpenoids 1–6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, B (2), four known derivatives, aculenes A–D 3–6, together with the secalonic acid D (7), were isolated from fermentation culture of fungus Aspergillus aculeatus. Their structures absolute configurations established by analyses their spectroscopic data, 1D 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) quantum chemical calculations. These metabolites...
The study reported the synthesis and antifungal activities in vitro against six phytopathogenic fungi of 17 novel N-[2-hydroxy-3,3-dimethyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butyl]benzamide derivatives. All target compounds were synthesized elucidated by means MS, high resolution (HR)-MS, IR, (1)H- (13)C-NMR analysis. results showed that almost all derivatives exhibited good each tested at concentration 50 µg/mL. Among them, 6h displayed excellent activity Alternaria alternata with median...
As a part of our continuing research on amine derivative antifungal agents, 19 novel target compounds containing 1,2,4-triazole and tertiary moieties were designed synthesized, their in vitro activities against six phytopathogenic fungi (Magnaporthe grisea, Alternaria solani, Fusarium Curvularia lunata, A. alternata, F. graminearum) assayed. All elucidated by means 1H-NMR, 13C-NMR, high resolution (HR)-MS, IR analysis. The results showed that most the derivatives exhibited obvious activity...
ABSTRACT An oligonucleotide biochip that specifically detects point mutations in the gyrA and parC genes of Neisseria gonorrhoeae was designed subsequently evaluated with 87 untreated clinical specimens. The susceptibilities N. strains were tested to determine prevalence ciprofloxacin-resistant Anhui Province, People's Republic China. Conventional DNA sequencing also performed identify confirm data. study demonstrates all easily discriminated by use biochip. Fifteen different alteration...
Abstract The power generation capacity of the wind turbine is derived from aerodynamic properties blade, which can be characterized by local flow state blade. In order to improve performance blade and furthermore efficiency turbine, top priority find abnormal area along take relevant strategies control flow. CFD-based spoiler design carried out in both root middlepiece respectively. Meanwhile, influence assembled spoilers on whole verified panel method BEM method. verification lays...
Two new insecticidal sesquiterpene polyol esters with a β-dihydroagarofuran skeleton, celangulatin A (1), B (2), and two known compounds, celangulin IV (3) V (4), were isolated from the leaves of Celastrus angulatus by bioassay-guided fractionation. Their chemical structures elucidated mainly analyses NMR MS spectral data. activities against Mythimna separate demonstrated KD50 value 68.5 215.8 μg g−1, respectively.