A5009189155- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Salivary Gland Disorders and Functions
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Urticaria and Related Conditions
- Immune Response and Inflammation
- Gout, Hyperuricemia, Uric Acid
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Salivary Gland Tumors Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Spondyloarthritis Studies and Treatments
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
- Eosinophilic Disorders and Syndromes
- Psoriasis: Treatment and Pathogenesis
University of Science and Technology of China
2019-2024
Anhui Provincial Hospital
2012-2021
Anhui Medical University
2011-2020
Hefei University
2019
First Affiliated Hospital of Henan University of Science and Technology
2019
Dongyang People's Hospital
2008
Wenzhou Medical University
2008
Systemic lupus erythematosus is a complex and potentially fatal autoimmune disease, characterized by autoantibody production multi-organ damage. By genome-wide association study (320 patients 1,500 controls) subsequent replication altogether involving total of 3,300 Asian SLE from Hong Kong, Mainland China, Thailand, as well 4,200 ethnically geographically matched controls, genetic variants in ETS1 WDFY4 were found to be associated with (ETS1: rs1128334, P = 2.33×10−11, OR 1.29; WDFY4:...
Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore plasma levels five (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) their potential as SLE biomarkers. Compared with healthy controls, GAS5 lnc-DC were significantly decreased (P < 0.001 P = 0.002, respectively) while linc0597 overexpressed patients 0.001). When...
Abstract Aim Febuxostat, a novel non‐purine selective inhibitor of xanthine oxidase, has been identified as potential alternative to allopurinol in patients with hyperuricemia. The purpose this study was compare the urate‐lowering ( UL ) efficacy and safety daily febuxostat C hinese gout Methods Gout n = 512) serum uric acid (s UA concentrations at least 8.0 mg/dL were randomized receive 40 mg or 80 300 for 28 weeks. Prophylaxis against flares meloxicam colchicine provided during weeks 1...
Abstract Aim To assess the clinical and laboratory features of primary Sjogren's syndrome ( pSS ) in a large teaching hospital China. Methods Three hundred fifteen patients diagnosed according to American‐European Classification Criteria consecutively admitted Anhui Provincial Hospital from 1 January 1999 30 September 2012 were retrospectively selected this study. Results The median age was 46.8 ± 14.4 years (range 13–83 years) majority female (96.5%). common at initial presentations dry...
We investigated the characteristics of Chinese SLE patients by analyzing association between specific autoantibodies and clinical manifestations 2104 from registry data CSTAR cohort. Significant (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle="italic">0.05</mml:mn></mml:math>) associations were found anti-Sm antibody, anti-rRNP malar rash; anti-RNP anti-SSA pulmonary arterial hypertension (PAH); anti-SSB antibody...