A5101884566- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Autoimmune Bullous Skin Diseases
- Atherosclerosis and Cardiovascular Diseases
- Rheumatoid Arthritis Research and Therapies
- Dermatologic Treatments and Research
- Pulmonary Hypertension Research and Treatments
- Galectins and Cancer Biology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Urticaria and Related Conditions
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Pharmaceutical studies and practices
- Venous Thromboembolism Diagnosis and Management
- Biosimilars and Bioanalytical Methods
- Bone and Joint Diseases
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Lymphatic System and Diseases
- Stress Responses and Cortisol
- Conducting polymers and applications
- Salivary Gland Disorders and Functions
- Mast cells and histamine
First Affiliated Hospital of GuangXi Medical University
2016-2025
Guangxi Medical University
2016-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2025
Children's Hospital of Zhejiang University
2024
Soochow University
2024
Chinese Academy of Fishery Sciences
2024
Zhangjiagang First People's Hospital
2024
Nantong University
2023
Affiliated Hospital of Nantong University
2023
China University of Mining and Technology
2023
High electronic conductivity and excellent specific capacitance still remain challenge for the practical application of hydrogel electrodes. Herein, a novel polymer composite electrode, PANI/PVA/ATMP/Ag (PPA-Ag), has been successfully constructed...
Patients with systemic lupus erythematosus (SLE) suffered from an increasing risk of cardiovascular diseases. In this multi-center prospective study, we aimed to determine the association between antiphospholipid antibodies (aPLs) and future atherosclerotic disease (ASCVD) in SLE. total, 1573 SLE patients were recruited based on Chinese Treatment Research group (CSTAR) registry. aPLs profile, including anticardiolipin (aCL) IgG/IgM, anti-β2 glycoprotein I (aβ2GPI) anticoagulant (LA),...
Remimazolam is a new benzodiazepine used for procedural sedation and general anesthesia. Several studies have remimazolam bendable bronchoscopy.
Pulmonary arterial hypertension (PAH) is a life-threatening complication of systemic lupus erythematosus (SLE). However, there no algorithm to identify those at high risk. This study was undertaken develop prediction model for PAH in patients with that provides individualized risk estimates.A multicenter, longitudinal cohort from January 2003 2020. The collected data on 3,624 consecutively evaluated diagnosed as having SLE. diagnosis confirmed by right-sided heart catheterization. Cox...
Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and internal organs. Th17 cells interleukin-17 (also called IL-17A) have been found to be increased in peripheral blood patients with SSc. IL-21 potent inducer differentiation that produced activated T cells, whose relationship SSc unclear. Here, using bleomycin (BLM)-induced mouse model fibrosis, we detected frequency CD4+/IL-17+ (Th17) CD4+/IL-21+ IL-21+ blood, lungs, as well serum content IL-17A...
Objective: The aim of our study was to assess the influence HLA-B27 status on axial spondyloarthritis (axSpA) in largest cohort China. Methods: An observational, cross-sectional, and analytic axSpA patients from China database performed. Demographic clinical data were compared terms status. Univariate multivariate analyses performed identify variables related presence. Results: We enrolled 4,131 this study; those, 36,95 (89.4%) positive. In analysis, male gender ( p < 0.001), younger...
This study explored the role of IL-35 in CD4+ T lymphocyte and human skin fibroblast (HSF) activity cytokine levels systemic sclerosis.Blood biopsies were collected from 41 patients 39 healthy controls to assess lymphocytes IL-35-related factors. co-cultured with HSFs, recombinant mAb evaluate cell viability, activation HSF cells.The proportion blood Th1/Th2 was lower Th17/Treg higher than (P < 0.05). IL-17A IFN-γ, IL-10 TGF-β controls. IL-17A, forkhead box P3, TGF-β1 collagen type I (COL-1)...
Organic redox additive hydroquinone (HQ) is incorporated into PANI hydrogel electrodes for flexible high-energy-density supercapacitors.
Abstract Aim Systemic sclerosis ( SS c) is characterized by immune abnormalities, progressive fibrosis of the skin and internal organs, microvascular injury damage. Interleukin‐21 receptor IL ‐21R) expressed in epidermis from patients with c. However, information describing role ‐21 c limited. Methods We established a mouse model bleomycin BLM )‐induced fibrosis. The frequency CD 4 + T, ‐21R T Th17 cells peripheral blood, lungs ‐induced mice were detected flow cytometry; levels blood...
Abstract Background: The impact of sex on the clinical manifestations rheumatoid arthritis (RA) were diversely reported in literature. Chinese Registry rhEumatoiD arthrITis provides a platform for investigation this issue patients. Methods: Demographic and parameters collected from all enrolled patients with RA early (disease duration ≤6 months). differences data regarding disease activity, comorbidities, medications compared between men women. proportions who achieved remission low activity...
Objective Patients with systemic lupus erythematosus (SLE) have an increased risk of venous thromboembolism (VTE). We conducted this study to develop a score algorithm for VTE in patients SLE that provides individualised estimates. Methods developed clinical prediction model 4502 based on the Chinese Treatment and Research group cohort (CSTAR) from January 2009 2020 externally validated 3780 CSTAR 2022. Baseline data were obtained events recorded during follow-up. The was predict within 6...
Abstract Objective To evaluate the immune regulatory and anti‐fibrosis function of thalidomide (Thal) in systemic sclerosis (SSc), we investigated effects Thal on: (a) Th17 Treg cell production; (b) related factors expression; (c) transforming growth factor (TGF)‐β1/Smad3 pathway, using a mouse model SSc. Methods Forty female BALB/c mice were randomly divided into normal control (NC) group, SSc group (bleomycin [BLM]‐induced experimental SSc), BLM + (10 mg/kg/day) (20) (30) group. was...
Abstract Background Avascular necrosis is a common organ damage in SLE patients, which can influence patients’ life quality. Conflicting results exist risk factors of AVN patients. The aim this study was to illustrate predicting the occurrence avascular (AVN), also known as osteonecrosis, systemic lupus erythematosus (SLE) patients Chinese Treatment and Research Group (CSTAR), multi-center cohort Methods CSTAR without existing at registration were included. At least two follow-ups an...
Objective Systemic sclerosis (SSc) is a chronic systemic disease characterized by immune dysregulation and fibrosis for which there no effective treatment. Animal models are crucial advancing SSc research. Tree shrews genetically, anatomically, immunologically closer to humans than rodents. Thus, the tree shrew model provides unique opportunity translational research in SSc. Methods In this study, was constructed subcutaneous injection of different doses bleomycin (BLM) 21 days. We assessed...