A5100742748- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Berberine and alkaloids research
- Helicobacter pylori-related gastroenterology studies
- Autism Spectrum Disorder Research
- Monoclonal and Polyclonal Antibodies Research
- Video Analysis and Summarization
- Geotechnical Engineering and Analysis
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Alzheimer's disease research and treatments
- Human Motion and Animation
- Diabetes and associated disorders
- Urinary Bladder and Prostate Research
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Oral Health Pathology and Treatment
- Hepatitis C virus research
- Pelvic floor disorders treatments
- Tactile and Sensory Interactions
- Extracellular vesicles in disease
Anhui Science and Technology University
2025
Anhui University of Science and Technology
2025
Baotou Medical College
2012-2025
Inner Mongolia University of Science and Technology
2012-2025
Public Health Clinical Center of Chengdu
2025
Lanzhou University
2025
Wenzhou-Kean University
2015-2024
University of Nottingham Ningbo China
2023-2024
Longyan University
2024
Changsha Central Hospital
2021-2023
Rheumatoid arthritis patients are at higher risk of developing comorbidities. The main objective this study was to evaluate the prevalence major comorbidities in Chinese rheumatoid patients. We also aimed identify factors associated with these Baseline demographic, clinical characteristics and comorbidity data from RA enrolled Registry rhEumatoiD arthrITis (CREDIT) Nov 2016 August 2017 were presented compared those five other registries across world. Possible related three (cardiovascular...
IMPORTANCE Digital health applications have been shown to be effective in the management of chronic diseases with simple treatment targets. The potential clinical value digital rheumatoid arthritis (RA) has not well studied. OBJECTIVE To investigate whether assessing patient-reported outcomes using could result disease control for patients RA. DESIGN, SETTING, AND PARTICIPANTS This is a multicenter, open-label randomized trial 22 tertiary hospitals across China. Eligible participants were...
Current diagnosis and treatment of rheumatoid arthritis (RA) is still challenging. More than one-third patients with RA could not be accurately diagnosed because lacking biomarkers. Our recent study reported that scavenger receptor-A (SR-A) a biomarker for RA, especially anticyclic citrullinated peptide antibody (anti-CCP)–negative RA. Here, we further identified the B cell autoantigenic epitopes SR-A. By large-scale multicenter including one training three validation cohorts 1954...
This single-center retrospective study aimed to explore the 1-year mortality risk factors in 166 patients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) undergoing maintenance hemodialysis (MH) between 6 June 2017 and 2023, construct a prediction model. The were classified into survival groups based on follow-up results, training validation sets at ratio of 1:1 (53 mortalities 53 survivors set 48 58 set). Stepwise logistic regression was used model...
Accumulation of amyloid-β (Aβ) in synaptic mitochondria is associated with mitochondrial and injury. The underlying mechanisms strategies to eliminate Aβ rescue defects remain elusive. Presequence protease (PreP), a peptidasome, novel degrading enzyme. Here, we demonstrate for the first time that increased expression active human PreP cortical neurons attenuates Alzheimer disease's (AD)-like amyloid pathology dysfunction, suppresses oxidative stress. Notably, PreP-overexpressed AD mice show...
Tumor-initiating stem cells (TSCs) are critical for drug resistance and immune escape. However, the mutual regulations between TSC tumor microenvironment (TME) remain unclear. Using DNA-label retaining, single-cell RNA sequencing (scRNA-seq), other approaches, we investigated intestinal adenoma in response to chemoradiotherapy (CRT), thus identifying therapy-resistant TSCs (TrTSCs). We find bidirectional crosstalk TME using CellPhoneDB analysis. An intriguing finding is that shape into a...
The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey primary SS China. recruited 483 patients from 16 Chinese medical centers nationwide January 2009 November 2011 and assessed salivary lacrimal gland dysfunction, organ involvement, autoimmunity these patients. cohort included 456 women 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median diagnosis, 49 range, 41–56 years). Male showed a...
Abstract Endophilin A1 (EP) is a protein enriched in synaptic terminals that has been linked to Alzheimer’s disease (AD). Previous vitro studies have shown EP can bind variety of proteins, which elicit changes transmission neurotransmitters and spine formation. Additionally, we previously showed levels are elevated AD patients transgenic animal models. Here, establish the vivo consequences upregulation expression amyloid-β peptide (Aβ)-rich environments, leading both long-term potentiation...
BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy (VAT) in the treatment Helicobacter pylori (H. ) is controversial. AIM To evaluate VAT Chinese population. METHODS This prospective, multicenter, randomized, open-label, and two-stage study was conducted at 23 centers Fujian, China (May 2021-April 2022). H. -infected patients were randomized to bismuth quadruple (BQT), BQT-Vonoprazan (BQT-V), seven-day (VAT-7), ten-day (VAT-10), fourteen-day (VAT-14) groups. primary endpoint...
To estimate the annual direct and indirect costs of rheumatoid arthritis (RA) in China identify predictors for cost illness.A cross-sectional study illness from societal perspective was conducted on 829 patients with RA 21 tertiary care hospitals between July 2009 December 2010. Data demographics, clinical variables, components were collected by physician interview. Costs represented US dollars using purchasing power parity estimates. Univariate multivariate linear regression analyses...
Diabetes is considered to be a risk factor in Alzheimer's disease (AD) pathogenesis. Although recent evidence indicates that diabetes exaggerates pathologic features of AD, the underlying mechanisms are not well understood. To determine whether mitochondrial perturbation associated with contribution AD progression, we characterized mouse models streptozotocin (STZ)-induced type 1 and transgenic diabetes. Brains from mice STZ-induced revealed significant increase cyclophilin D (CypD)...
Maize is a critical crop for food, feed, and bioenergy worldwide. This study characterized the genetic diversity population structure of 212 important inbred lines collected from Southeast China breeding program using Maize6H-60K single nucleotide polymorphism (SNP) array. To investigate architecture plant height (PH) ear (EH), genome-wide association analysis (GWAS) was performed on this in 2021 2022. Cluster grouped maize into 10 distinct categories. GWAS identified significant...
Systemic lupus erythematosus (SLE) is frequently associated with a lower rate of live birth and higher incidence adverse pregnancy outcomes (APOs), can also increase the risk SLE flares. Comprehensive preconception assessment critical for improved in patients SLE. Unfortunately, no global consensus on conditions that should fulfill prior to has yet been formed. This study aimed investigate before optimize outcomes. was retrospective utilizing data from multicenter Chinese cohort. Information...
To investigate whether primary Sjögren's syndrome (pSS) patients with hyperglobulinemia have an increased risk of all-cause mortality.Patients who registered in the Chinese Rheumatism Data Centre from May 2016 to July 2021 and met 2002 American European Consensus Group criteria or College Rheumatology /European League Against classification for were included. Hyperglobulinemia was defined as any elevated serum levels immunoglobulin G (IgG), A (IgA), M (IgM). The outcome death. demographic...
This study aimed to analyze potential biomarkers for systemic sclerosis (SSc) by constructing lncRNA-miRNA-mRNA networks in circulating exosomes (cirexos). Differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) SSc cirexos were screened using high-throughput sequencing detected with real-time quantitative PCR (RT-qPCR). genes (DEGs) analyzed the DisGeNET, GeneCards, GSEA4.2.3, Gene Ontology (GO), Kyoto Encyclopedia of Genes Genomes (KEGG) databases. Receiver operating...
As of now, there are no satisfactory treatments for spinal cord injury (SCI), so new therapeutic approaches necessary to be explored. Adipose-derived mesenchymal stem cell exosomes (ADMSC-Exo), delightfully, show remarkable effects. Therefore, we try investigate the effects and mechanisms ADMSC-Exo on SCI, as well provide novel treatment SCI. cells (ADMSC) were isolated from rats then (Exo) extracted cells. The Exo identified by flow cytometry, transmission electron microscopy nanoparticle...