A5103074511- Ginger and Zingiberaceae research
- Biological and pharmacological studies of plants
- Drug-Induced Hepatotoxicity and Protection
- Berberine and alkaloids research
- Ginseng Biological Effects and Applications
- Polysaccharides and Plant Cell Walls
- Gut microbiota and health
- Plant-based Medicinal Research
- Curcumin's Biomedical Applications
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Aldose Reductase and Taurine
- Traditional Chinese Medicine Analysis
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Bioactive natural compounds
- Essential Oils and Antimicrobial Activity
- Chromatography in Natural Products
- Probiotics and Fermented Foods
- Phytochemical Studies and Bioactivities
- Adipose Tissue and Metabolism
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Chemotherapy-induced organ toxicity mitigation
- Cardiac Ischemia and Reperfusion
Fujian University of Traditional Chinese Medicine
2024-2025
Guangzhou University of Chinese Medicine
2017-2020
Centre for Drug Research and Development
2018
State Council of the People's Republic of China
2017
The effect of polysaccharides isolated from Dendrobium officinale (DOP) on acetaminophen‐ (APAP‐) induced hepatotoxicity and the underlying mechanisms involved are investigated. Male Institute Cancer Research (ICR) mice were randomly assigned to six groups: (1) control, (2) vehicle (APAP, 230 mg/kg), (3) N ‐acetylcysteine (100 (4) 50 mg/kg DOP, (5) 100 (6) 200 DOP. Alanine aminotransferase (ALT) aspartate (AST) levels in serum glutathione (GSH), malondialdehyde (MDA), catalase (CAT), total...
Curcumin (CUR), a widely used food additive, is derived mainly from<italic>Curcuma</italic>species that has been applied traditionally for treating hepatocellular carcinoma (HCC).
Polydatin protects against acetaminophen-induced hepatotoxicity in mice.
Acute liver injury is a common consequence of taking overdose acetaminophen (APAP). The aim this study was to evaluate the antioxidant activity and hepatoprotective effect mangrove plant Sonneratia apetala fruit extract (SAFE) on APAP-induced in mice. Mice were orally pretreated with SAFE (100, 200, 400 mg/kg) daily for one week. control APAP groups intragastrically administered distilled water, NAC group treated N-Acetyl-L-cysteine (NAC) before exposure. results manifested that...
Constipation is a common disorder that significant source of morbidity among people around the world ranging from 2% to 28%. Dendrobium officinale Kimura et Migo traditional herbal medicine and health food used for tonicity stomach promotion body fluid production in China. This study aimed prepare ultrafine powder (UDO) investigate its laxative effect potential mechanism mice with diphenoxylate-induced constipation. Results indicated mean diameter (d50) UDO obtained by ball milling was 6.56...
Curcumin (CUR), a promising natural-occurring dietary compound for the treatment of hepatocellular carcinoma (HCC), was closely associated with its metabolite.
Hypertension-induced cardiac disease is a common complication and significant contributor to mortality in hypertensive patients, largely due cardiomyocyte apoptosis. Although Trifolin has been identified as potential antihypertensive compound, its therapeutic role hypertension-induced injury remains uncertain.
The chemical compositions of EFH were identified using LC-ESI-MS. mice with 3% DSS-induced UC administered (200, 400, and 800 mg/kg), sulfasalazine (SASP, 200 azathioprine (AZA, 13 mg/kg) for 10 days via daily gavage. colonic inflammation was evaluated by the disease activity index (DAI), length, histological scores, levels inflammatory mediators. gut microbiota characterized 16S rRNA gene sequencing analysis.LC-ESI-MS analysis showed that rich in alkaloids flavones. results indicated...
The aim of this study was to investigate the hepatoprotective effect ultrafine powder Dendrobium officinale (UDO) against acetaminophen (APAP)-induced liver injury in mice. ICR mice were orally administered with UDO (100, 200, 400 mg/kg/day) for 14 days before intraperitoneal injection APAP. results showed that exhibited a significant dose-dependently preventive on APAP-induced hepatotoxicity. Pretreatment significantly reduced serum levels alanine transaminase and aspartate...