A5101651870- Berberine and alkaloids research
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Ginger and Zingiberaceae research
- Plant-based Medicinal Research
- Alkaloids: synthesis and pharmacology
- Gut microbiota and health
- Chromatography in Natural Products
- Inflammatory Bowel Disease
- Plant biochemistry and biosynthesis
- Skin Protection and Aging
- Flavonoids in Medical Research
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Phytochemical compounds biological activities
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Phytochemical Studies and Bioactivities
- Medicinal Plant Pharmacodynamics Research
- Papaya Research and Applications
- Traditional and Medicinal Uses of Annonaceae
- Helicobacter pylori-related gastroenterology studies
- Natural product bioactivities and synthesis
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2015-2024
Zunyi Medical University
2019
Guangzhou University of Chinese Medicine
2016-2019
Guangzhou University
2013
First Affiliated Hospital of Chinese PLA General Hospital
2013
Jinan University
2010
Xiaomi (China)
2007
Berberine (BBR) is a promising anti-diabetic isoquinoline alkaloid from Rhizoma coptidis, while its bioavailability was extremely low. Here, the existing form and pharmacokinetics of BBR were comparatively characterized in conventional antibiotic-induced pseudo germ-free (PGF) rats. Furthermore, we investigated antidiabetic effect potential mechanism intestinal oxidative metabolite oxyberberine (OBB) STZ-induced diabetic Results showed that OBB existed mainly as protein-bound blood,...
Andrographolide sodium bisulfate (ASB), a water-soluble form made from andrographolide through sulfonating reaction, is an antioxidant and anti-inflammatory drug; however, the antiphotoaging effect of ASB has still not been revealed. Oxidative stress inflammation are known to be responsible for ultraviolet (UV) irradiation induced skin damage consequently premature aging. In this study, we aimed at examining on UV-induced photoaging mice by physiological histological analysis examination...
Ulcerative colitis (UC) is a chronic relapsing disease without satisfactory treatments, in which intestinal inflammation and disrupted epithelial barrier are two main pathogeneses triggering UC. Berberrubine (BB) deemed as one of the major active metabolite berberine (BBR), naturally-occurring isoquinoline alkaloid with appreciable anti-UC effect. This study aimed to comparatively investigate therapeutic effects BB BBR on dextran sodium sulfate (DSS)-induced mouse model, explore potential...
Millettiae speciosae Champ. Leguminosae (MSC), is a well-known Chinese herb traditionally used as food material and medicine for enhancing physical strength. Our preliminary study found that the aqueous extract of this (MSE) had an anti-fatigue effect. In paper, we further separated MSE into total polysaccharides (MSP) supernatant (MSS) by alcohol precipitation, explored which fraction was active its Mice were orally administered with MSP or MSS at doses 200, 400, 800 mg/kg 20 days effect...
Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]).To improve water solubility and absolute bioavailability of BD, we developed self-nanoemulsifying drug delivery system (SNEDDS) composing MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) BD. The physicochemical properties pharmacokinetics BD-SNEDDS were...
Silymarin has been used in the treatment of a number liver diseases for long time, but its efficacy preventing triptolide induced acute hepatotoxicity not reported previously. The present study aimed to assess protective effect silymarin against (TP)-induced rats. Rats were orally administrated with (50, 100 and 200 mg/kg) 7 days received intraperitoneal TP (2 on day 8. Hepatic injuries comprehensively evaluated terms serum parameters, morphological changes, oxidative damage, inflammation...
Berberine (BBR) is an active component of Phellodendri Cortex (PC), which a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) hundreds years. Many studies reported the anti-inflammatory and nephroprotective properties BBR PC; however, therapeutic effects on HUA have not explored. This study aims to investigate efficacy mechanism treating HUA.The in treatment were predicted by network pharmacology. A mouse model established potassium oxonate hypoxanthine...
As a tropical medicinal plant, Sonneratia apetala is mainly distributed in the southeast coastal areas of China. Recently, hypouricemic effect leaves and branches (SAL) has been reported, but active compound its mechanism are unclear. Thus, this study aims to explore effective fraction SAL on uric acid formation excretion. was extracted with ethyl acetate concentrated obtain solvent-free extracts (SAL-EA). The remains (SAL-E) supernatant (SAL-S) resulting from water extraction alcohol...
The aim of this study was to investigate the anti-inflammatory property ethanol extract root and rhizome Pogostemon cablin (ERP). effect evaluated using four animal models including xylene-induced mouse ear edema, acetic acid-induced vascular permeability, carrageenan-induced pleurisy, hind paw edema. Results indicated that oral administration ERP (120, 240, 480 mg/kg) significantly attenuated decreased capillary inhibited neutrophils recruitment, reduced in a dose-dependent manner....
Inflammatory bowel disease (IBD) is a chronic immune-related mainly caused by the disequilibrium of T helper (Th) cell paradigm? Pogostone (PO) one major chemical constituents Pogostemon cablin (Blanco) Benth. The present study aims to investigate potential benefit PO against IBD in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis model. treatment enema significantly brought down activity index (DAI) TNBS-challenged rats, which was manifested ameliorated inflammatory...
Brucea javanica oil (BJO), one of the main products javanica, has been widely used in treating different kinds malignant tumors. Quassinoids are major category anticancer phytochemicals B. javanica. However, current researches on anti-cancer effect BJO mainly focused oleic acid and linoleic acid, common components dietary edible oils, essential characteristic like quassinoids potentially involved remained unexplored. In investigation, we developed an efficient HPLC method to detect brusatol,...