A5101935326- Metal complexes synthesis and properties
- Analytical chemistry methods development
- Ferrocene Chemistry and Applications
- Electrochemical sensors and biosensors
- Bamboo properties and applications
- Molecular Sensors and Ion Detection
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Chromatography
- Immune Cell Function and Interaction
- Antibiotics Pharmacokinetics and Efficacy
- Luminescence and Fluorescent Materials
- Tryptophan and brain disorders
- Nanoparticle-Based Drug Delivery
- Crop Yield and Soil Fertility
- Graphene research and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Nanomaterials for catalytic reactions
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- Ginseng Biological Effects and Applications
- Carbon and Quantum Dots Applications
Guangzhou Medical University
2022-2025
Tianjin University
2015-2025
Sichuan Agricultural University
2024-2025
Second Affiliated Hospital of Guangzhou Medical University
2022-2025
Nanjing Medical University
2010-2024
Huaian First People’s Hospital
2012-2024
Guangdong University of Technology
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Guangzhou University
2007-2024
Beijing University of Chinese Medicine
2024
Magic bullets: A drug-loaded structure comprising a PEGylated (PEG=polyethylene glycol) gold nanoshell on silica nanorattle spheres (GSNs; see picture) combines remote-controlled photothermal therapy with chemotherapy. Tumor cells are killed higher efficacy and less toxicity than the free drug. Detailed facts of importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please...
In the present study, a novel colorimetric sensing platform was constructed for quantitative detection of acetylcholinesterase (AChE) activity and its inhibitor. Manganese dioxide (MnO2) nanosheets as an oxidase-mimicking nanomaterial could directly oxidize 3,3',5,5'-tetramethylbenzidine (TMB) into oxTMB without need horseradish peroxidase H2O2. When AChE introduced, acetylthiocholine be catalytically hydrolyzed to produce thiocholine, which easily triggers decomposition MnO2 nanosheets,...
The drug-loaded, transferrin and poly(ethylene glycol) (PEG)-functionalized gold nanoshells on silica nanorattles (pGSNs-Doc-Tf) can combine the active targeting, passive remote-controlled photothermal therapy together with chemotherapy to completely kill tumor cells via a single irradiation near-infrared laser light.
A new form of graphene-coated silica (GCS) has been prepared by mixing exfoliated graphene oxide with acid-treated and reducing it hydrazine hydrate so that coats the particles. This method is simple, convenient, robust. The GCS composite particles have characterized using optical photographs, Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET) analysis, elemental analysis. These analyses...
At present, enzyme-linked immunosorbent assay (ELISA) is considered to be the most appropriate approach in clinical biomarker detection, with good specificity, low cost, and straightforward readout. However, unsatisfactory sensitivity severely hampers its wide application diagnosis. Herein, we designed a new kind of enhanced fluorescence (FELISA) based on human alpha-thrombin (HAT) triggering "turn-on" signals. In this system, detection antibodies (Ab2) HAT were labeled gold nanoparticles...
Mesoporous silica nanoparticles grafted with light-responsive polymer on the outer surface were developed as novel nanogated ensembles, which allow encapsulation and release of drug biological molecules under light irradiation.
Magische Kügelchen: Eine wirkstoffbeladene Struktur bestehend aus einer PEGylierten (PEG=Polyethylenglycol) Gold-Nanoschale mit eingeschlossenen SiO2-Kügelchen (siehe Bild) verbindet die ferngelenkte Photothermaltherapie der Chemotherapie. Tumorzellen werden wirksamer und geringerer Giftwirkung abgetötet als dem freien Wirkstoff. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...
Merging different components into a single nanoparticle can exhibit profound impact on various biomedical applications including diagnostics, imaging, and therapy. However, retaining the unique properties of each component after integration has proven to be significant challenge. Our previous research demonstrated that gold nanoshells polystyrene spheres have potential in photohermal Here, we report facile green strategy synthesize multifunctional nanocomposite with Fe3O4 core coated as dual...
An artificial enzymatic cascade system with high activity and stability is engineered based on Fe3O4–Au@mesoporous SiO2 (MS) microspheres, which possess both intrinsic glucose oxidase (GOx)- peroxidase-mimic activities.
Abstract Interleukin (IL)-27, a newly discovered IL-12 family cytokine, is composed of p28 and EBI3. In this study, CD11c-p28 f/f conditional knockout mice were generated to delete specifically in dendritic cells (DCs). We demonstrated that the absence DC-derived p28, these highly susceptible both low higher concentrations concanavalin A (ConA) (5 mg/kg or 10 mg/kg), with extremely early steady high levels interferon-γ (IFN-γ) sera. Neutralizing IFN-γ prevented ConA-induced liver damage...
Lactobacillus is one of the bacteria strains which has been widely used in human life, valuable probiotic properties. In present study, L. reuteri FLRE5K1 was isolated from healthy mouse kidney and tested for its anti-melanoma activity cell assays animal models. The results showed that could significantly reduce incidence melanoma 70 % to 30 prolonged survival tumor-bearing mice. Despite significant effect on prevention, tumor mass remained uneliminated. alanine aminotransferase (ALT) level...
The source–sink ratio during grain filling is a critical factor that affects crop yield in wheat, and the main objective of this study was to determine relations at both canopy scale individual culm level under two nitrogen (N) levels post-jointing stage. Nine widely-used cultivars were chosen for analyzing southwestern China; three typical different plant types subjected artificial manipulation grain-filling supplement growth measurements. A field experiment conducted over consecutive...
Hypertensive nephropathy (HTN) is the second leading cause of end-stage renal disease (ESRD) and a chronic inflammatory disease. Persistent hypertension leads to lesions intrarenal arterioles arterioles, luminal stenosis, secondary ischemic parenchymal damage, glomerulosclerosis, tubular atrophy, interstitial fibrosis. Studying pathogenesis hypertensive prerequisite for diagnosis treatment. The main HTN poor long-term blood pressure control, but kidney damage often accompanied by occurrence...
A novel enzyme sensor based on CdSe quantum dots (QDs)/polycaprolactone (PCL) composite porous fibers has been prepared via a simple electrospinning method. We choose PCL, biocompatible polymer, as the host polymer for electrospun and prepare QDs sensing probes. Experiments demonstrate that are miscible chemically inert to PCL in solvent mixture containing N,N-dimethylformamide chloroform. Therefore, uniformly distributed within fibers, leading good preservation of their original...
Silica nanorattles (SNs) have proven to be promising vehicles for drug delivery. In order further enhance efficacy and minimize adverse effects, active targeted delivery tumors is necessary. this work, SNs modified with a tumor specific targeting ligand, folic acid (FA), was used as carrier of doxorubicin (DOX) (DOX–FA-SNs). Drug loading, cytotoxicity cellular uptake DOX–FA-SNs in vitro human cervical carcinoma cells (HeLa cells) were evaluated. showed higher than DOX loaded carboxyl (–COOH)...
Abstract Critical roles of IL-27 in autoimmune diseases and infections have been reported; however, the contribution endogenous to tumor progression remains elusive. In this study, by using IL-27p28 conditional knockout mice, we demonstrate that is critical protective immune response against methyl-cholanthrene–induced fibrosarcoma transplanted B16 melanoma, dendritic cells (DCs) are primary source. DC-derived required for shaping microenvironment inducing CXCL-10 expression myeloid-derived...
The effect of polysaccharides isolated from Dendrobium officinale (DOP) on acetaminophen‐ (APAP‐) induced hepatotoxicity and the underlying mechanisms involved are investigated. Male Institute Cancer Research (ICR) mice were randomly assigned to six groups: (1) control, (2) vehicle (APAP, 230 mg/kg), (3) N ‐acetylcysteine (100 (4) 50 mg/kg DOP, (5) 100 (6) 200 DOP. Alanine aminotransferase (ALT) aspartate (AST) levels in serum glutathione (GSH), malondialdehyde (MDA), catalase (CAT), total...