A5086792863- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- CAR-T cell therapy research
- Renal and related cancers
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Microfluidic and Bio-sensing Technologies
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Plant Gene Expression Analysis
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Chronic Lymphocytic Leukemia Research
- Ferroptosis and cancer prognosis
Institute of Hematology & Blood Diseases Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Beijing Normal University - Hong Kong Baptist University United International College
2024
Jinan University
2016-2024
Union Hospital
2004-2024
Jilin University
2012-2024
Northwest A&F University
2023-2024
Powerchina Huadong Engineering Corporation (China)
2024
CD8 + T cell activation leads to the rapid proliferation and differentiation of effector cells (T effs ), which mediate antitumor immunity. Although aerobic glycolysis is preferentially activated in , mechanisms that regulate glucose uptake low-glucose acidic tumor microenvironment (TME) remain poorly understood. Here, we report abundance transporter GLUT10 increased during Specifically, deficiency inhibited uptake, glycolysis, efficiency tumor-infiltrating cells. Supplementation with alone...
Abstract Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been extensively investigated for their therapeutic potential in treating inflammatory disorders. However, the mechanisms underlying immunosuppressive function of MSCs are not fully understood, hindering development standardized MSC-based therapies clinical use. In this study, we profile single-cell transcriptomes isolated from adipose tissue (AD), bone marrow (BM), placental chorionic membrane (PM),...
A group of resident ER proteins have been identified that are proposed to function as molecular chaperones. The best characterized these is BiP/GRP78, an hsp70 homologue binds peptides containing hydrophobic residues in vitro and unfolded or unassembled vivo. However, evidence mammalian BiP plays a direct role protein folding remains circumstantial. In this study, we examine how interacts with particular substrate, immunoglobulin light chain (lambda LC), during its folding. Wild-type hamster...
Abstract Interleukin (IL)-27, a newly discovered IL-12 family cytokine, is composed of p28 and EBI3. In this study, CD11c-p28 f/f conditional knockout mice were generated to delete specifically in dendritic cells (DCs). We demonstrated that the absence DC-derived p28, these highly susceptible both low higher concentrations concanavalin A (ConA) (5 mg/kg or 10 mg/kg), with extremely early steady high levels interferon-γ (IFN-γ) sera. Neutralizing IFN-γ prevented ConA-induced liver damage...
Significance Enhancing the generation and function of memory T cells represents a crucial strategy to improve protective immunity against pathogens tumors. The signaling pathway via mechanistic target rapamycin (mTOR) has been implicated in regulation differentiation effector cells, but upstream regulators or downstream mechanisms remain unclear. In this study, we provide insight into basis that controls mTOR T-cell responses. deficiency tuberous sclerosis 1 (Tsc1) antigen-experienced...
Apple rust is a serious fungal disease affecting Malus plants worldwide. Infection with the pathogen Gymnosporangium yamadae induces accumulation of anthocyanins in to resist disease. However, mechanism anthocyanin biosynthesis regulation against apple still unclear. Here, we show that MpERF105 and MpNAC72 are key regulators via ethylene-dependent pathway M. 'Profusion' leaves under stress. Exogenous ethephon treatment promoted high expression G. yamadae-infected leaves. Overexpression...
It has been demonstrated that the two main subsets of peripheral γδ T cells, Vγ1 and Vγ4, have divergent functions in many diseases models. Recently, we reported Vγ4 cells played a protective role tumor immunity through eomesodermin-controlled mechanisms. However, precise roles immunity, especially whether any interaction with remain unknown. We this paper suppressed cell-mediated antitumor function both vitro vivo, suppression was cell contact independent. Using neutralizing anti-IL-4 Ab or...
Abstract Critical roles of IL-27 in autoimmune diseases and infections have been reported; however, the contribution endogenous to tumor progression remains elusive. In this study, by using IL-27p28 conditional knockout mice, we demonstrate that is critical protective immune response against methyl-cholanthrene–induced fibrosarcoma transplanted B16 melanoma, dendritic cells (DCs) are primary source. DC-derived required for shaping microenvironment inducing CXCL-10 expression myeloid-derived...
Invariant NKT (iNKT) cells recently were classified into NKT1, NKT2, and NKT17 lineages with distinct transcription factor cytokine profiles, but the mechanisms underlying such fate decisions remain elusive. In this article, we report crucial roles for mechanistic target of rapamycin (mTOR) signaling, especially mTORC2, in iNKT cell development determination cells. Loss Rictor, an obligatory component decreased thymic peripheral cells, which was associated defective survival. Strikingly,...