A5011607483- Cardiac electrophysiology and arrhythmias
- Drug Transport and Resistance Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Algal biology and biofuel production
- Ion channel regulation and function
- Photosynthetic Processes and Mechanisms
- Nanopore and Nanochannel Transport Studies
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Neuroscience and Neuropharmacology Research
- Electrochemical Analysis and Applications
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Fuel Cells and Related Materials
- Membrane-based Ion Separation Techniques
- Microbial metabolism and enzyme function
- Microbial Metabolic Engineering and Bioproduction
- Gut microbiota and health
- Pediatric Hepatobiliary Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Nicotinic Acetylcholine Receptors Study
- Pulmonary Hypertension Research and Treatments
- Alcohol Consumption and Health Effects
Qilu Hospital of Shandong University
2024-2025
China Aerodynamics Research and Development Center
2025
Harvard University
2018-2024
Lishui University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Northwest A&F University
2024
Boston VA Research Institute
2019-2022
Anhui Agricultural University
2021
Zhejiang University
2012-2019
Hangzhou Xixi hospital
2015-2019
Background— Hypertrophic cardiomyopathy (HCM), the most common mendelian heart disorder, remains an orphan of disease-specific pharmacological treatment because limited understanding cellular mechanisms underlying arrhythmogenicity and diastolic dysfunction. Methods Results— We assessed electromechanical profile cardiomyocytes from 26 HCM patients undergoing myectomy compared with those nonfailing nonhypertrophic surgical by performing patch-clamp intracellular Ca 2+ (Ca i ) studies....
The human gut microbiota impacts host metabolism and has been implicated in the pathophysiology of obesity metabolic syndromes. However, defining roles specific microbial activities metabolites on phenotypes proven challenging due to complexity microbiome-host ecosystem. Here, we identify strains from abundant bacterial phylum Bacteroidetes that display selective bile salt hydrolase (BSH) activity. Using isogenic wild-type BSH-deleted
Abstract Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme crosslinks collagen—Lysyl oxidase-like 2 (Loxl2)—is essential for interstitial mechanical dysfunction pathologically stressed hearts. In mice, cardiac stress activates fibroblasts to express secrete Loxl2 into interstitium, triggering fibrosis, systolic diastolic Antibody-mediated inhibition or genetic disruption greatly reduces stress-induced chamber dilatation,...
Inhibition of cardiac late sodium current (late I<sub>Na</sub>) is a strategy to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia heart failure. Current inhibitors I<sub>Na</sub> are unselective can be proarrhythmic. This study introduces GS967 (6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine), potent selective inhibitor I<sub>Na</sub>, demonstrates its effectiveness ventricular arrhythmias. The effects on rabbit...
Background— Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular redox and survival by suppressing reactive oxygen species generation inhibiting apoptosis stress kinase-1 (ASK1)–dependent apoptotic signaling. To date, the role of Trx2 system in heart failure pathogenesis has not been investigated. Methods Results— Western blot histological analysis revealed expression levels were reduced hearts from patients with dilated cardiomyopathy, concomitant increase ASK1...
Oxygen (O2) is involved in many life activities, and its vivo monitoring of vital importance. In electrochemistry with carbon fiber microelectrode (CFME) has been proven to be a suitable technique, but the surface fouling propensity poses great challenge current stability reliability. Herein we electro-grafted silica nanoporous membrane (SNM) consisting uniform, closely packed, vertically aligned nanochannels on CFME surface, which was capable protecting effectively from biofouling and,...
Thermosensation, the ability to detect environmental temperature change, is one of most ancient and crucial processes for survival all living organisms. Mammals use temperature-sensitive transient receptor potential (thermoTRP) cation channels as thermometers convert change into electrical signals that are finally received action potentials by nerve endings. In this work, we report bionic thermosensation solid-state hybrid nanochannels based on principle thermally sensitive permselective ion...
Protein kinase C (PKC) isozymes move upon activation from one intracellular site to another. PKC-binding proteins, such as receptors for activated (RACKs), play an important role in regulating the localization and diverse functions of PKC isozymes. RACK1, receptor betaIIPKC, determines functional activity betaIIPKC. However, mechanism by which RACK1 localizes betaIIPKC is not known. Here, we provide evidence that changes response activation. In Chinese hamster ovary cells transfected with...
Late Na + current ( I NaL ) and Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) are both increased in the diseased heart. Recently, CaMKII was found to phosphorylate channel 1.5 (Na v 1.5), resulting enhanced . Conversely, an increase of would be expected cause elevation intracellular activation CaMKII. However, a relationship between enhancement has yet demonstrated. We investigated whether influx via leads explored functional significance this pathway. In neonatal rat ventricular...
An ultrathin and highly porous silica isoporous membrane was employed as a nanofluidic power source to harness osmotic energy from salinity gradients.
Apple rust is a serious fungal disease affecting Malus plants worldwide. Infection with the pathogen Gymnosporangium yamadae induces accumulation of anthocyanins in to resist disease. However, mechanism anthocyanin biosynthesis regulation against apple still unclear. Here, we show that MpERF105 and MpNAC72 are key regulators via ethylene-dependent pathway M. 'Profusion' leaves under stress. Exogenous ethephon treatment promoted high expression G. yamadae-infected leaves. Overexpression...
Relapse is the most serious limitation of effective medical treatment opiate addiction. Opiate-related behaviors appear to be modulated by cannabinoid CB1 receptors (CB1) through poorly understood cross-talk mechanisms. Opiate and are coexpressed in nucleus accumbens (NAc) dorsal striatum. These regions also have highest density adenosine A2a (A2a) brain. We been investigating postsynaptic signaling mechanisms μ-opiate (MORs) primary NAc/striatal neurons. In this article, we present evidence...
Inherited human aldehyde dehydrogenase 2 (ALDH-2) deficiency reduces the risk for alcoholism. Kudzu plants and extracts have been used 1,000 years in traditional Chinese medicine to treat contains daidzin, which inhibits ALDH-2 suppresses heavy drinking rodents. Decreased due inhibition is attributed aversive properties of acetaldehyde accumulated during alcohol consumption. However, daidzin can reduce some rodents without necessarily increasing acetaldehyde. Therefore, a selective inhibitor...