A5108553656- CAR-T cell therapy research
- Electrospun Nanofibers in Biomedical Applications
- Supramolecular Self-Assembly in Materials
- Sulfur-Based Synthesis Techniques
- Advanced Photocatalysis Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Structural Health Monitoring Techniques
- Tissue Engineering and Regenerative Medicine
- Adsorption and biosorption for pollutant removal
- Polymer Surface Interaction Studies
- Non-Destructive Testing Techniques
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Nanomaterials for catalytic reactions
- Graphene and Nanomaterials Applications
- T-cell and B-cell Immunology
- Advanced Battery Materials and Technologies
- Ultrasonics and Acoustic Wave Propagation
- Advancements in Battery Materials
- Infant Development and Preterm Care
- Copper-based nanomaterials and applications
- Seismic Waves and Analysis
- Indoor and Outdoor Localization Technologies
- Structural Behavior of Reinforced Concrete
- Virus-based gene therapy research
Fujian Medical University
2018-2025
Union Hospital
2018-2025
Carnegie Mellon University
2025
Bohai University
2025
Huazhong Agricultural University
2005-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Shaanxi Normal University
2024
Fujian University of Technology
2020-2024
Huaqiao University
2019-2024
Institute of Hematology & Blood Diseases Hospital
2021-2024
Mimicking nature: The reversible formation of self-assembled nanostructures selenium-containing peptides can be controlled by redox triggers (see scheme, VC=vitamin C). As a consequence, the catalytic activity these is switchable. These results should lead to development nature-mimicking smart materials with promising properties. Self-assembly abundant in nature, ranging from relatively simple systems, such as lipid bilayers cell membranes and double-helical DNA structure, complex structures...
Abstract Size‐exclusion chromatography (SEC) is a widely adopted method for the isolation of extracellular vesicles (EVs) from complex samples. SEC can efficiently remove high‐abundant proteins, while often requires multiple fractionation operation using diversified column settings. In this study, we aim to establish simplified acquire high quality EVs. comparison all three cross‐linked Sepharose resins with sample types FBS and human serum (HS), CL‐6B CL‐4B showed superior performance in...
Abstract Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been extensively investigated for their therapeutic potential in treating inflammatory disorders. However, the mechanisms underlying immunosuppressive function of MSCs are not fully understood, hindering development standardized MSC-based therapies clinical use. In this study, we profile single-cell transcriptomes isolated from adipose tissue (AD), bone marrow (BM), placental chorionic membrane (PM),...
Vascular regeneration and patency maintenance, without anticoagulant administration, represent key developmental trends to enhance small-diameter vascular grafts (SDVG) performance. In vivo engineered autologous biotubes have emerged as SDVG candidates with pro-regenerative properties. However, mechanical failure coupled thrombus formation hinder translational prospects of SDVGs. Previously fabricated poly(ε-caprolactone) skeleton-reinforced (PBs) circumvented issues achieved regeneration,...
Background Approximately two-thirds of patients with relapsed or refractory large B-cell lymphoma (R/R LBCL) do not respond to relapse after anti-CD19 chimeric antigen receptor T (CAR T)-cell therapy, leading poor outcomes. Previous studies have suggested that intensified lymphodepletion and hematological stem cell infusion can promote adoptively transferred T-cell expansion, enhancing antitumor effects. Therefore, we conducted a phase I/II clinical trial in which CNCT19 (an CAR T-cell) was...
Lead (Pb) and arsenic (As) are commonly occurring heavy metals in the environment produce detrimental impacts on central nervous system. Although they have both been indicated to exhibit neurotoxic properties, it is not known if joint effects, their mechanisms of action likewise unknown. In this study, zebrafish were exposed different concentrations Pb (40 μg/L, 4 mg/L), As (32 3.2 mg/L) combinations μg/L + 32 mg/L for 30 days. The histopathological analyses showed significant brain damage...
To investigate the application value of multimodal hysterosalpingo-contrast sonography (HyCoSy) combined with negative hysterography in assessing tubal patency and diagnosing uterine lesions. A total 310 infertility patients were selected examined using HyCoSy to evaluate Based on doctors' experience levels, they divided into high seniority group (more than 5 years Contrast-enhanced ultrasound) low (resident doctors). Various ultrasound modes, including two-dimensional contrast-enhanced...
A β-galactosidase-responsive molecular hydrogelator of a nitric oxide (NO) donor can release NO in controllable manner to improve wound healing.
We demonstrate that a tripeptide hydrogelator, Nap-FFG, can selectively self-assemble at the surface of platelets, thus inhibiting ADP-, collagen-, thrombin- and arachidonic acid (AA)-induced human platelet aggregations with IC(50) values 0.035 (41), 0.14 (162), 0.062 (68), 0.13 mg/mL (148 μM), respectively. Other hydrogelators chemical structures Nap-FFX (X = A, K, S, or E) could not possessed less potencies to inhibit aggregations. observed higher amounts Nap-FFG by techniques LC-MS...
Here we reported on the first example of using disulfide bond as a cleavable linker to control molecular self-assembly and formation small (SM) hydrogels.
Small molecular hydrogels that can respond to external stimuli have great potentials for controlled drug release. In this study, we report on a small hydrogel of Ac-YYYY-OMe whose gel–sol phase transition could be triggered by an oxidase enzyme tyrosinase. We also synthesized three compounds with similar chemical structures Ac-YYYpY-OMe replacing tyrosine (Y) phenylalanine (F). Though they form phosphatase, the gels formed F couldn't change clear solutions The in study were characterized...
Recurrent nonsevere hypoglycemia (RH) can lead to cognitive dysfunction in patients with diabetes, although the involved mechanisms remain unclear. Here, we aimed investigate mechanism underlying RH-induced deficits a focus on mitochondrial homeostasis. To establish model that mimicked RH type 1 diabetes (T1DM) receiving insulin therapy, streptozotocin-induced mice T1DM were subjected recurrent, twice-weekly injections over 4 wk. We found disrupted fine structure, reduced number of...