A5101988730- Aquatic Ecosystems and Phytoplankton Dynamics
- Air Quality and Health Impacts
- Zebrafish Biomedical Research Applications
- Environmental Toxicology and Ecotoxicology
- Marine Toxins and Detection Methods
- Biocrusts and Microbial Ecology
- Heavy Metal Exposure and Toxicity
- Climate Change and Health Impacts
- Sperm and Testicular Function
- Advanced oxidation water treatment
- Microplastics and Plastic Pollution
- Birth, Development, and Health
- Wnt/β-catenin signaling in development and cancer
- Neonatal Respiratory Health Research
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Electrochemical Analysis and Applications
- Advanced Glycation End Products research
- Nanoparticles: synthesis and applications
- Marine Invertebrate Physiology and Ecology
- Water-Energy-Food Nexus Studies
- Marine and coastal ecosystems
- Reproductive biology and impacts on aquatic species
- Diverse Aspects of Tourism Research
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
Shanxi University
2015-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2020-2024
Hubei Academy of Agricultural Sciences
2015-2024
Xuzhou Medical College
2022-2024
State Key Laboratory of Environmental Chemistry and Ecotoxicology
2024
Research Center for Eco-Environmental Sciences
2023-2024
Atrial natriuretic peptide (ANP) is a cardiac hormone essential for the regulation of blood pressure. In myocytes, ANP synthesized as precursor, pro-ANP, that converted to biologically active by an unknown membrane-associated protease. Recently, we cloned transmembrane serine protease, corin, highly expressed in heart. this study, examine effects corin on pro-ANP processing. Our results show recombinant human converts and cleavage sequence specific. findings suggest long-sought...
A novel cDNA has been identified from human heart that encodes an unusual mosaic serine protease, designated corin. Corin a predicted structure of type II transmembrane protein and contains two frizzled-like cysteine-rich motifs, seven low density lipoprotein receptor repeats, macrophage scavenger receptor-like domain, trypsin-like protease domain in the extracellular region. Northern analysis showed corin mRNA was highly expressed heart. In mice, detected by situ hybridization cardiac...
PM2.5 (particulate matter ≤ 2.5 μm) is one of the leading environmental risk factors for global burden disease. Whereas increasing evidence has linked adverse roles with cardiovascular and respiratory diseases, limited but growing emerging suggests that exposure can affect nervous system, causing neuroinflammation, synaptic dysfunction cognitive deterioration. However, molecular mechanisms underlying deficits elicited by are largely unknown. C57BL/6 mice received oropharyngeal aspiration (1...
As a global problem, fine particulate matter (PM 2.5 ) really needs local fixes. Considering the increasing epidemiological relevance to anxiety and depression but inconsistent toxicological results, most important question is clarify whether how PM causally contributes these mental disorders which components are dangerous for crucial mitigation in particular place. In present study, we chronically subjected male mice real-world exposure system throughout winter heating period coal...
Lead (Pb) and arsenic (As) are commonly occurring heavy metals in the environment produce detrimental impacts on central nervous system. Although they have both been indicated to exhibit neurotoxic properties, it is not known if joint effects, their mechanisms of action likewise unknown. In this study, zebrafish were exposed different concentrations Pb (40 μg/L, 4 mg/L), As (32 3.2 mg/L) combinations μg/L + 32 mg/L for 30 days. The histopathological analyses showed significant brain damage...
Corin is a type II transmembrane serine protease abundantly expressed in the heart. In previous study using transfected 293 cells, we showed that corin converted pro-atrial natriuretic peptide (pro-ANP) to atrial (ANP), suggesting likely pro-ANP convertase. Because other proteases such as thrombin and kallikrein had previously also been shown cleave vitro, it remained demonstrate indeed endogenous convertase cardiomyocytes. this study, examined processing murine cardiac muscle cell line,...
Abstract Bcl-w, a prosurvival member of the Bcl-2 family, is essential for spermatogenesis. However, mechanisms by which Bcl-w participates in regulation apoptosis testis are largely unknown. To explore potential role testis, expression mRNA and protein during testicular development spermatogenesis, dimerization with proapoptosis members responses to hormonal stimulation vitro apoptosis-inducing signals vivo were investigated. Both detected Sertoli cells, spermatogonia, spermatocytes, as...
Cyanobacteria-derived microcystin-leucine-arginine (MCLR), commonly characterized as a hepatotoxin, has recently been found to show neurotoxicity, but the exact mechanism is still unknown. To further our understanding of neurotoxic effects MCLR and mechanisms behind it, we used two-dimensional gel electrophoresis mass spectrometry analysis identify global protein profiles associated with MCLR-induced neurotoxicity. MCLR-treated hippocampi showed alterations in proteins involved cytoskeleton,...
Abstract Air pollution has been reported to be associated with increased risks of cognitive impairment and neurodegenerative diseases. Because NO 2 is a typical primary air pollutant an important contributor secondary aerosols, -induced neuronal functional abnormalities have attracted greater attention, but the available experimental evidence, modulating mechanisms, targeting medications remain ambiguous. In this study, we exposed C57BL/6J APP/PS1 mice dynamic inhalation found for first time...
Abstract Background As one of the environmental risk factors for human health, atmospheric fine particulate matter (PM 2.5 ) contributes to cognitive deterioration in addition respiratory and cardiovascular injuries. Recently, increasing evidence implicates that PM inhalation can affect neurological functions offspring, but sex-specific outcomes underlying biological processes are largely unknown. Objectives To observe influence prenatal exposure on performance elucidate neuronal...
The organ-specific toxicity resulting from microplastic (MP) exposure has been extensively explored, particularly concerning the gut, liver, testis, and lung. However, under natural conditions, these effects are not restricted to specific organs or tissues. Investigating whether MP presents a systemic threat an entire organism, impacting factors such as lifespan, sleep, fecundity, is essential. In this study, we investigated of dietary two different doses MPs (1-5 μm) using terrestrial model organism
Microcystin-LR (MCLR) is a commonly encountered blue–green algal hepatotoxin and known inhibitor of cellular protein phosphatase. However, little about its neurotoxicity. By using Morris water maze, histopathological biochemical analysis, we investigated MCLR-induced neurotoxicity on the hippocampus rat brain. After rats were intrahippocampally injected with MCLR (1 10 μg/L), their learning memory function was greatly impaired, suggesting neurotoxic potential MCLR. Meanwhile, obvious...