A5100437570- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Biopolymer Synthesis and Applications
- Microplastics and Plastic Pollution
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- Bone Tissue Engineering Materials
- Carbon dioxide utilization in catalysis
- Enzyme Catalysis and Immobilization
- Polyamine Metabolism and Applications
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Enzyme Production and Characterization
- Bacteriophages and microbial interactions
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Silk-based biomaterials and applications
- Anesthesia and Neurotoxicity Research
- Additive Manufacturing and 3D Printing Technologies
- Microbial Metabolic Engineering and Bioproduction
- Diabetic Foot Ulcer Assessment and Management
- Polymer crystallization and properties
- Advanced Nanomaterials in Catalysis
- Periodontal Regeneration and Treatments
Nankai University
2016-2025
Beijing Chaoyang Emergency Medical Center
2025
State Key Laboratory of Medicinal Chemical Biology
2013-2024
Yancheng Third People's Hospital
2024
Xinxiang Medical University
2020-2023
Sichuan Normal University
2022
Hebei Chemical and Pharmaceutical College
2021
State Key Laboratory of Chemical Engineering
2021
Chinese General Hospital College of Nursing and Liberal Arts
2016
City University of Hong Kong
2010
The activated sludge process is an essential for treating domestic and industrial wastewaters in most wastewater treatment plants (WWTPs). This consists of a mixture general special microorganisms form complex enrichment population. Thus, the exploration microbial communities crucial to improve performance process. In this study, we investigated phylogenetic diversity metabolic potential full-scale WWTPs. Four 16S rRNA gene clone libraries were constructed from samples. all samples,...
Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing desiderated with the function of promoting revascularization anti-bacteria. Herein, multifunctional injectable composite hydrogel was prepared by incorporation cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG synthesized combining sol-gel method template method, which maintained spherical...
Small extracellular vesicles (sEVs) secreted by mesenchymal stem cells (MSCs) have been extensively studied in recent years. sEV contents change with the secreting cell state. When MSCs are exposed to an inflammatory environment, they release more functional growth factors, exosomes, and chemokines. Herein, stimulated alter cargos functions regulate microenvironment promote tissue regeneration. Sequencing of miRNAs shows that certain RNAs conducive function upregulated. In this study, vitro...
Extracellular vesicles (EVs) play an important role in intercellular communication, and the function of EVs mainly depends on state source cells. To determine effect diabetic microenvironment secreted by bone marrow mesenchymal stem cells (BMSCs), this work explores normal glucose (5.5 mm) cultured BMSCs derived (NG-EVs) high (30 (HG-EVs) regulating migration, proliferation osteoblastic differentiation vitro. In order to improve bioavailability EVs, constructs a sustained release system...
Genome streamlining is a feasible strategy for constructing an optimum microbial chassis synthetic biology applications. Genomic islands (GIs) are usually regarded as foreign DNA sequences, which can be obtained by horizontal gene transfer among microorganisms. A model strain Pseudomonas putida KT2440 has broad applications in biocatalysis, biotransformation and biodegradation.In this study, the identified GIs P. accounting 4.12% of total genome size were deleted to generate series...
Abstract Background Genome reduction and metabolic engineering have emerged as intensive research hotspots for constructing the promising functional chassis various microbial cell factories. Surfactin, a lipopeptide-type biosurfactant with broad spectrum antibiotic activity, has wide application prospects in anticancer therapy, biocontrol bioremediation. Bacillus amyloliquefaciens LL3, previously isolated by our lab, contains an intact srfA operon genome surfactin biosynthesis. Results In...
Existing treatment methods encounter difficulties in effectively promoting skin wound healing, making this a serious challenge for clinical treatment. Extracellular vesicles (EVs) secreted by stem cells have been proven to contribute the regeneration and repair of tissue, but they cannot be targeted sustained, which seriously limits their current therapeutic potential. The recombinant human collagen III protein (rhCol III) has advantages good water solubility, an absence hidden viral...
Chronic diabetic wounds have become a significant cause of disability worldwide. It is highly desired to develop effective therapies that can promote the rapid healing wounds. Owing outstanding hydrophilic and water-retaining properties, hydrogels could accelerate process. Extracellular vesicles (EVs) shown ability cell regeneration angiogenesis. In this study, we chose gelatin methacryloyl (GelMA) hydrogel, kind biomaterial characteristic good biocompatibility, load EVs derived from...
Diabetic skin wounds are difficult to heal quickly due insufficient angiogenesis and prolonged inflammation, which is an urgent clinical problem. To address this problem, it becomes imperative develop a dressing that can promote revascularization reduce inflammation during diabetic healing. Herein, multifunctional collagen (CTM) was constructed by loading large efficacy-potentiated exosome-mimicking nanovesicles (L-Meseomes) into porous sponge with transglutaminase (TGase). L-Meseomes were...
Abstract The cationic site of the enzyme rhodanese forms ion pairs with substrate and product anions, thiosulfate, cyanide, sulfite, thiocyanate. It also such diverse anionic species as acetate, formate, sulfate, glycinate. In rate studies, equilibrium constants their temperature dependencies were evaluated for interactions most these anions both free sulfur-substituted intermediate. ionic strength substrate, thiosulfate ion, inhibitor, sulfate determined. results this study provide a basis...
Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play roles promoting wound repair. Methods: The purpose of this research was prepare a novel thermo-sensitive hydrogel-poly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) (PP) loaded with superoxide dismutase (SOD) improve the effect for treatment. micromorphology observed by scanning...
Abstract Hydrogels have been extensively favored as drug and cell carriers for the repair of knee cartilage defects. Recruiting mesenchymal stem cells (MSCs) in situ to defect region could reduce risk contamination during delivery, which is a highly promising strategy enhance repair. Here, cell-free tissue engineering (TE) system was developed by applying an injectable chitosan/silk fibroin hydrogel. The hydrogel release first stromal cell-derived factor-1 (SDF-1) then kartogenin (KGN)...
In this article, we report a novel surface modification method for cellulose fiber that is based on supramolecular assembly. Beta-cyclodextrin (beta-CD) was first covalently grafted onto the surface. Then poly(epsilon-caprolactone) (PCL) oligomers having both ends capped with adamantane motifs (i.e., PCL-AD) were immobilized to through host-guest inclusion complexation between beta-CD and AD motif. FTIR-ATR XPS analyses confirmed successful assembly of PCL-ADs, which further supported by...
Environmentally Degradable Parameter (EdK) is of importance in the describing biodegradability environmentally biodegradable polymers (BDPs). In this study, a concept EdK was introduced. A test procedure using ISO 14852 method and detecting evolved carbon dioxide as an analytical parameter developed, calculated used indicator for ultimate materials. Starch polyethylene reference materials were defined values 100 0, respectively. Natural soil samples inoculated into bioreactors, followed by...
In this study, we developed a method for the dual functionalization of poly(ε-caprolactone) (PCL) surface by means supramolecular assembly technology. Polyethylene glycol (PEG), with resistance to protein adsorption, and TPSLEQRTVYAK (TPS) peptide, which can specifically bind endothelial progenitor cells (EPCs), were immobilized on PCL through host-guest inclusion complexation. The chemical composition as well hydrophilic/hydrophobic property functionalized was characterized X-ray...