A5100690531- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Galectins and Cancer Biology
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Macrophage Migration Inhibitory Factor
- Catalytic Processes in Materials Science
- Ga2O3 and related materials
- Esophageal and GI Pathology
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Tuberculosis Research and Epidemiology
- Ubiquitin and proteasome pathways
- ZnO doping and properties
- Nanomaterials for catalytic reactions
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Catalysis and Oxidation Reactions
- Ammonia Synthesis and Nitrogen Reduction
- Colorectal Cancer Screening and Detection
- Phagocytosis and Immune Regulation
- Advanced Nanomaterials in Catalysis
- Tendon Structure and Treatment
- Biliary and Gastrointestinal Fistulas
China Medical University
2024
General Hospital of Shenyang Military Region
2012-2024
University of Jinan
2022-2024
Liaoning Cancer Hospital & Institute
2024
Peking University
2022-2023
Shanghai Jiao Tong University
2023
Shanghai Ninth People's Hospital
2023
Command Hospital
2023
Yangzhou University
2022-2023
East China University of Science and Technology
2023
Carbon quantum dots (CQDs) offer huge potential due to their enzymatic properties as compared natural enzymes. Thus, discovery of CQDs-based nanozymes with low toxicity from resources, especially daily food, implies a promising direction for exploring treatment strategies human diseases. Here, we report biocompatible nanozyme prepared chlorogenic acid (ChA), major bioactive product coffee. We found that ChA CQDs exhibited obvious GSH oxidase-like activities and subsequently promoted cancer...
The E2F family of transcription factors play a crucial role in the development various cancers. However, members lack targetable binding pockets and are typically considered "undruggable". Unlike canonical small-molecule therapeutics, molecular glues mediate new E3 ligase-protein interactions to induce selective proteasomal degradation, which represents an attractive option overcome these limitations.Human proteome microarray was utilized identify natural product-derived glue for targeting...
Existing treatment methods encounter difficulties in effectively promoting skin wound healing, making this a serious challenge for clinical treatment. Extracellular vesicles (EVs) secreted by stem cells have been proven to contribute the regeneration and repair of tissue, but they cannot be targeted sustained, which seriously limits their current therapeutic potential. The recombinant human collagen III protein (rhCol III) has advantages good water solubility, an absence hidden viral...
Abstract Placenta accreta spectrum (PAS) is a high-risk obstetrical condition associated with significant morbidity and mortality. Current clinical screening modalities for PAS are not always conclusive. Here, we report nanostructure-embedded microchip that efficiently enriches both single clustered circulating trophoblasts (cTBs) from maternal blood detecting PAS. We discover uniquely high prevalence of cTB-clusters in subsequently optimize the device to preserve intactness these clusters....
Abstract Understanding the direct interaction of nanostructures per se with biological systems is important for biomedical applications. However, whether regulate by targeting specific cellular proteins remains largely unknown. In present work, self‐assembling nanomicelles are constructed using small‐molecule oleanolic acid (OA) as a molecular template. Unexpectedly, without modifications functional ligands, OA significantly activate proteasome function directly binding to 20S subunit alpha...
To leverage complementary mechanisms for cancer cell removal, we developed a novel engineering and therapeutic strategy co-opting phagocytic clearance antigen presentation activity into T cells. We engineered chimeric engulfment receptor (CER)-1236, which combines the extracellular domain of TIM-4, recognizing "eat me" signal phosphatidylserine, with intracellular signaling domains (TLR2/TIR, CD28, CD3ζ) to enhance both TIM-4-mediated phagocytosis cytotoxic function. CER-1236 cells...
Background Community-acquired pneumonia (CAP) is a common infectious disease throughout the world and incidence continues to grow as population ages. Aspiration an important pathogenic mechanism for in elderly management of patients with community-acquired aspiration factors major medical problem. Our study aimed assess whether moxifloxacin comparison levofloxacin plus metronidazole are effective safe treatment factors. Methods In this prospective, multicenter, open-label, randomized...
The purpose of this study is to develop a validated 3D finite element model the pelvic floor system which can offer insights into mechanics anterior vaginal wall prolapse and have ability assess biomedical device treatment methods. results should accurately mimic clinical findings due intra-abdominal pressure (IAP) soft tissues impairment conditions.A was created in Creo Parametric 2.0 based on MRI Images, included uterus, cervix, vagina, cardinal ligaments, uterosacral simplified levator...
To evaluate the long-term outcomes and safety of endoscopic transsphenoidal surgery (ETS) in recurrent residual pituitary adenomas (rrPAs), as well predictors gross total resection (GTR) intraoperative CSF leakage. Furthermore, to compare complications with non-rrPAs cohort.Clinical radiological characteristics patients rrPAs who underwent ETS were collected between 2017 2020. Data from 2019 Logistic regression analyses performed investigate factors influencing Between-group comparisons...
Cancer Cell Pyroptosis In article number 2205531, Ke-Wu Zeng and co-workers describe the natural product oleanolic acid-based self-assembling nanostructures specially bind to proteasome subunit alpha 6 (PSMA6) activate for cancer cell pyroptosis. This study opens up a new direction development anti-cancer nanomedicine from resources.
Mutations in the SCN8A gene encoding voltage-gated sodium channel α-subunit Nav1. 6 have been reported individuals with epilepsy, intellectual disability and features of autism spectrum disorder. is widely expressed central nervous system, including cerebellum. Cerebellar dysfunction has implicated We investigated conditional Scn8a knockout mice under C57BL/6J strain background that specifically lack expression cerebellar Purkinje cells (Scn8aflox/flox , L7Cre+ mice). morphology was analyzed...
This study aimed to explore the mechanism of Danzikang Knee Joint Granules in regulating differentiation mesenchymal stem cells into cartilage repair knee osteoarthritis based on TGF-β signaling pathway. For this purpose, 60 SD rats were divided four groups; control group and treated groups with low, medium, high concentrations Danzikang. The histopathology was analyzed pathway-related proteins determined. Results showed that average optical density serum Granule intervention significantly...
Compared with self-prepared LRD, a prepackaged low-residue diet (LRD) can improve patient compliance, but whether it further the quality of bowel preparation is uncertain. The study aimed to compare application formula LRD in for colonoscopy.A multicenter randomized controlled trial was conducted 15 centers. eligible subjects were randomly assigned one two groups: group and group. On day before colonoscopy, instructed consume restricted prepared by themselves, while given six bags them...