A5100666762- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Antimicrobial agents and applications
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Fuel Cells and Related Materials
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Wound Healing and Treatments
- Histone Deacetylase Inhibitors Research
- Antimicrobial Peptides and Activities
- Peer-to-Peer Network Technologies
- Photodynamic Therapy Research Studies
- Synthetic Organic Chemistry Methods
- Nanoparticle-Based Drug Delivery
- Privacy-Preserving Technologies in Data
- Scientific Computing and Data Management
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Army Medical University
2020-2025
Southwest Hospital
2023-2025
University of Hong Kong
2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou University of Chinese Medicine
2025
Guangxi Medical University
2025
Jiangnan University
2024
Northwest A&F University
2024
m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process found be upregulated cancers, including CRC. Here, we investigate and underlying mechanism of development CRC.The expression was detected large clinical patient samples. To evaluate function vitro vivo, colony formation, CCK-8, cell migration invasion assays were performed. find out downstream target METTL3, GEO dataset re-mined. We analyzed...
Chemically inert, mechanically tough, cationic metallo-polyelectrolytes were conceptualized and designed as durable anion-exchange membranes (AEMs). Ring-opening metathesis polymerization (ROMP) of cobaltocenium-containing cyclooctene with triazole the only linker group, followed by backbone hydrogenation, led to a new class AEMs polyethylene-like framework alkaline-stable cobaltocenium cation for ion transport. These exhibited excellent thermal, chemical mechanical stability, well high conductivity.
Abstract We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC by performing digital scoring on the purified EVs. Earlier creates more opportunities curative therapeutic interventions. EVs are present in circulation at relatively stages disease, providing potential detection. develop an EV (i.e., Click Chips) synergistically integrating chemistry-mediated capture/release, multimarker antibody...
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Abstract Background Though circular RNAs, new non‐coding RNA classes have demonstrated that they an essential role in the initiation as well development of CRC (colorectal cancer), whereas function and mechanism hsa_circ_0001666 are less known. Methods Hsa_circ_0001666 was identified by bioinformatics analysis a circRNA microarray from GEO database, its expression both cell lines tissues analysed. A series vitro along with vivo experiments were carried out for exploring functions, including...
Abstract Cancer-associated fibroblasts (CAFs) are the most abundant stromal components in tumor microenvironment (TME) and closely involved progression. However, precise biological functions molecular mechanisms of CAFs TME have yet to be understood. Here, we demonstrate that WEE2-AS1 is highly expressed CAF-derived small extracellular vesicles (sEVs). Moreover, markedly higher plasma sEVs CRC patients than healthy subjects its high level predicts advanced pathological staging poor survival....
Abstract GPR176 belongs to the G protein‐coupled receptor superfamily, which responds external stimuli and regulates cancer progression, but its role in colorectal (CRC) remains unclear. In present study, expression analyses of are performed patients with cancer. Genetic mouse models CRC coupled Gpr176‐deficiency investigated, vivo vitro treatments conducted. A positive correlation between upregulation proliferation poor overall survival is demonstrated. confirmed activate cAMP/PKA signaling...
Abstract Harnessing cross‐species regenerative cues to direct human potential is increasingly recognized as an excellent strategy in medicine, particularly for addressing the challenges of impaired wound healing aging populations. The skin mucus Andrias davidianus plays a critical role self‐protection and tissue repair, yet fundamental factors mechanisms involved remain elusive. Here, this work presents evidence that glycosaminoglycans (GAGs) derived from secretion (SAGs) serve potent...
Bacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug-resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer-antibiotic bioconjugates on gold nanoparticles developed as an antibacterial agent fight against different strains. Thus, these nanoparticle conjugates combine various components in system display enhanced bactericidal efficacy, which...
Tumor-derived extracellular vesicles (EVs) present in bodily fluids are emerging liquid biopsy markers for non-invasive cancer diagnosis and treatment monitoring. Because the majority of EVs circulation not tumor origin, it is critical to develop new platforms capable enriching tumor-derived from blood. Herein, we introduce a biostructure-inspired NanoVilli Chip, highly efficient reproducible immunoaffinity capture blood plasma samples. Anti-EpCAM-grafted silicon nanowire arrays were...
Abstract Background Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nevertheless, biological functions circRNAs and underlying mechanisms by which they regulate colorectal (CRC) progression remain unclear. Methods A novel circRNA (circ-GALNT16) was identified microarray qRT-PCR. series vitro vivo phenotype experiments were performed to investigate circ-GALNT16 CRC. The FISH, RNA pulldown assay, RIP...
Well-preserved molecular cargo in circulating extracellular vesicles (EVs) offers an ideal material for detecting oncogenic gene alterations cancer patients, providing a noninvasive diagnostic solution detection of disease status and monitoring treatment response. Therefore, technologies that conveniently isolate EVs with sufficient efficiency are desperately needed. Here, lipid labeling click chemistry-based EV capture platform ("Click Beads"), which is message ribonucleic acid (mRNA)...
Abstract Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) has been proven to participate in the ubiquitination of multiple substrate proteins. However, underlying mechanisms UBE2J1 as a ubiquitin-conjugating participating cancer development and progression remain largely unknown. Here, we identified that is downregulated colorectal (CRC) tissues cell lines which are mediated by DNA hypermethylation its promoter, decreased associated with poor prognosis. Functionally, serving suppressor gene...
Photodynamic therapy (PDT) has long been receiving increasing attention for the minimally invasive treatment of cancer. The performance PDT depends on photophysical and biological properties photosensitizers (PSs). always-on fluorescence signal conventional PSs makes it difficult to real-time monitor phototherapeutic efficacy in process. Therefore, functional with good photodynamic effect self-reporting are highly desired. Here, two nonemissive iridium(III) solvent complexes,...
Abstract The homology‐independent targeted integration (HITI) strategy enables effective CRISPR/Cas9‐mediated knockin of therapeutic genes in nondividing cells vivo, promising general solutions for treating genetic diseases like X‐linked juvenile retinoschisis. Herein, supramolecular nanoparticle (SMNP) vectors are used codelivery two DNA plasmids—CRISPR‐Cas9 genome‐editing system and a gene, Retinoschisin 1 (RS1)—enabling clustered regularly interspaced short palindromic repeats...
Abstract Background Hypoxic tumour microenvironment (TME) is a key regulator in cancer progression. However, the communications between hypoxic cells and other components TME during colorectal (CRC) progression via extracellular vesicles (EVs) remain unclear. Methods High‐throughput sequencing was employed to detect aberrantly expressed microRNAs (miRNAs) EVs. Quantitative real‐time PCR used confirm screen preliminarily candidate miRNAs. The effects of EVs derived from hypoxia (<1% O 2 )...
Abstract Placenta accreta spectrum (PAS) is a high-risk obstetrical condition associated with significant morbidity and mortality. Current clinical screening modalities for PAS are not always conclusive. Here, we report nanostructure-embedded microchip that efficiently enriches both single clustered circulating trophoblasts (cTBs) from maternal blood detecting PAS. We discover uniquely high prevalence of cTB-clusters in subsequently optimize the device to preserve intactness these clusters....
Abstract Previous data demonstrate that JMJD2A is a cancer-associated gene and may be involved in human breast cancer by demethylation of H3K9me3. The aim this study was to investigate depressive effects on transfection with JMJD2A-sepcific siRNA cell line MDA-MB-231 proliferation, invasion migration. JMJD2A-specific chemically synthesised transfected into MDA-MB-231. Expression levels were detected quantitative real-time PCR Western blot analysis. Cells proliferation evaluated using flow...