A5101459228- Advanced Thermoelectric Materials and Devices
- Circular RNAs in diseases
- Chalcogenide Semiconductor Thin Films
- RNA Research and Splicing
- Perovskite Materials and Applications
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Thermal properties of materials
- Advanced Semiconductor Detectors and Materials
- Heusler alloys: electronic and magnetic properties
- X-ray Diffraction in Crystallography
- Quantum Dots Synthesis And Properties
- Crystallization and Solubility Studies
- Thermal Expansion and Ionic Conductivity
- Advanced Battery Materials and Technologies
- 2D Materials and Applications
- Cancer Mechanisms and Therapy
- Protein Tyrosine Phosphatases
- Cancer, Hypoxia, and Metabolism
- Magnetic and transport properties of perovskites and related materials
- Phase Change Materials Research
- Thermal Radiation and Cooling Technologies
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2021-2025
Nanjing University of Science and Technology
2022-2024
Nanjing Drum Tower Hospital
2018-2021
Nanjing Normal University Taizhou College
2018
Nanjing Normal University
2018
Abstract Increasing evidence shows that the anti-tumor functions of tumor-infiltrating T lymphocytes (TILs) were inhibited significantly, but underlying mechanisms remain not fully understood. In this study, we found 14-3-3ζ expression was up-regulated in hepatocellular carcinoma (HCC) cells and TILs. TILs with high-expression (14-3-3ζ high ) exhibited impaired activation (CD69), proliferation (Ki67) compared to low Flow cytometry assay showed CD8 + cells, ones higher frequency exhausted...
Abstract Background Though circular RNAs, new non‐coding RNA classes have demonstrated that they an essential role in the initiation as well development of CRC (colorectal cancer), whereas function and mechanism hsa_circ_0001666 are less known. Methods Hsa_circ_0001666 was identified by bioinformatics analysis a circRNA microarray from GEO database, its expression both cell lines tissues analysed. A series vitro along with vivo experiments were carried out for exploring functions, including...
Abstract The untapped potential of sub‐nanometric materials (SNMs) in constructing high‐performance thermoelectrics (TE) presents a promising yet unexplored avenue. This study investigates the utilization supertetrahedral CdS clusters, representing SNMs, conjunction with state‐of‐the‐art Bi 2 Te 3 ‐based systems. cluster size‐dependent electronic structure enables selective interface scattering carriers, while its 1 nm size and phonon density states (DOS) contribute to significant...
The all-inorganic halide perovskite CsPbX3 (X = Cl, Br, or I) offers various advantages, such as tunable electronic structure and high carrier mobility. However, its potential application in thermoelectric materials remains underexplored. In this study, we propose a simple yet effective method to synthesize CsPbX3/Bi0.4Sb1.6Te3 (BST) nanocomposite by sintering uniformly mixed raw powder. intrinsic excitation of the BST system is suppressed exploiting rich phase electrical transport...
Long non-coding RNAs (lncRNAs) have been reported to play pivotal roles in multiple tumors and can act as tumor biomarkers. In this study, we explored the association of expression an lncRNA, DGCR5 with clinicopathological features prognosis HCC.Expression levels were detected by quantitative real-time PCR (qRT-PCR) clinical data was obtained, including basic information, clinicopathology cancer specific survival rate. Receiver operating characteristic (ROC) curve, Kaplan-Meier methods...
Abstract Background Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nevertheless, biological functions circRNAs and underlying mechanisms by which they regulate colorectal (CRC) progression remain unclear. Methods A novel circRNA (circ-GALNT16) was identified microarray qRT-PCR. series vitro vivo phenotype experiments were performed to investigate circ-GALNT16 CRC. The FISH, RNA pulldown assay, RIP...
Single-atom materials are widely explored in catalysis, batteries, sensors, etc. However, limited by mass production and centimeter-scale assembly, they rarely studied thermoelectrics. Herein, we demonstrate a solvothermal synthesis assisted syringe-pump method to yield Bi2S3-supported Pt single-atom (Bi2S3-Pt1) at 10 g scale. Different from Ptn clusters, Pt1 single atoms can increase carrier concentration high doping efficiency provide unique atomic environment enhance mobility, an enlarged...
Phase-junction nanocomposites, made of nanograins with the same composition but different phases, offer a platform to optimize physiochemical performance materials. Herein, we demonstrate straightforward strategy synthesize Cu2-x S phase-junction nanocomposites by retaining surface 1-dodecanethiol (DDT) ligands, in contrast traditional method that strips ligands. As result, phase junctions between conventional monoclinic (m) and an unconventional metastable tetragonal (t) are obtained. The...
Abstract Colorectal cancer (CRC) is one of the most common cancers around world and endangers human health seriously. Liver metastasis an important factor affecting long-term prognosis CRC specific mechanism CRLM (colorectal with liver metastasis) not fully understood. LZTS1 has been found dysregulated in many cancers, especially CRC. Theories suggested that hypermethylation promoter regions was responsible for abnormal expression multiple malignant tumors. Although role cell proliferation...
Size plays a crucial role in chemistry and material science. Subnanometer polyoxometalate (POM) clusters have gained attention various fields, but their use thermoelectrics is still limited. To address this issue, we propose the POM as an effective second phase to enhance thermoelectric properties of Bi0.4Sb1.6Te3. Thanks subnanometer size, improve electrical transport behavior through superposition atomic orbitals interfacial scattering effect. Furthermore, ultrasmall size strongly reduces...
Colorectal cancer (CRC) progression and metastasis involve numerous regulatory factors. Among these, cellular retinoic acid-binding protein 2 (CRABP2) has been implicated as both a tumor activator suppressor. Here, it is aimed to clarify the role of CRABP2 in CRC growth explore underlying molecular mechanisms mediating its functions. Using vitro vivo models, including colonocyte-specific conditional knockout mouse model (Crabp2ΔIEC) subcutaneous tumorigenesis assay BALB/c nude mice, shown...
Background/Aims: During the occurrence and progression of hepatocellular carcinoma (HCC), phosphotyrosine phosphatases (PTPs) are usually described as tumor suppressors or proto-oncogenes, to some degree correlated with prognosis HCC. Methods: A total 321 patients from Cancer Genome Atlas (TCGA) database 180 our validated cohort were recruited in this study. Kaplan-Meier, univariate multivariate Cox proportional hazards model used evaluate risk factors for survival. Quantitative real-time...
The Rashba effect and point defect scattering significantly enhance zT of entropy-stabilized Sn 0.8 Ge 0.2 Te Se with disorder on cationic anionic sites.
Abstract For Bi x Sb 2− Te 3 (BST) in thermoelectric field, the element ratio is easily influenced by chemical environment, deviating from stoichiometric and giving rise to various intrinsic defects. In P‐type polycrystalline BST, are primary forms of Defect engineering a crucial strategy for optimizing electrical transport performance 2 ‐based materials, but achieving synchronous improvement thermal challenging. this study, mesoporous SiO utilized successfully mitigate adverse impacts...
Abstract Mg 3 (Sb,Bi) 2 alloys offer exceptional near‐room temperature thermoelectric (TE) performance comparable to Bi Te . However, the low carrier mobility due vacancies and relatively high lattice thermal conductivity adversely affect overall TE performance. Herein, of are decoupled by modulating both phase interface grain boundaries through incorporating different sizes iron (Fe). Ferromagnetic micrometer‐sized Fe particles enhance figure merit ( ZT ) more than superparamagnetic...
Abstract Phase‐junction nanocomposites, made of nanograins with the same composition but different phases, offer a platform to optimize physiochemical performance materials. Herein, we demonstrate straightforward strategy synthesize Cu 2− x S phase‐junction nanocomposites by retaining surface 1‐dodecanethiol (DDT) ligands, in contrast traditional method that strips ligands. As result, phase junctions between conventional monoclinic (m) and an unconventional metastable tetragonal (t) are...
Background: Inflammation and apoptosis play a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Suppressor cytokine signaling 2 (SOCS2) is one classic negative regulators signaling, which has recently been described as anti-inflammatory mediators. However, SOCS2 macrophages during NASH relationship among SOCS2, inflammation, largely unknown. Herein, we aimed to study function progression.Methods: We detected expression human subjects without steatosis, with simple...