A5100424547- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Mycobacterium research and diagnosis
- Image Processing Techniques and Applications
- Food Quality and Safety Studies
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Connexins and lens biology
- Endoplasmic Reticulum Stress and Disease
- Surface Roughness and Optical Measurements
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Heat shock proteins research
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Platelet Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
Tianjin Medical University
2020-2025
Second Hospital of Tianjin Medical University
2020-2025
Binzhou Medical University
2023-2024
Second Affiliated Hospital of Zhejiang University
2017-2024
Binzhou University
2023
Yantai University
2023
Nanchang University
2021-2023
First Affiliated Hospital of Nanchang University
2021-2023
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Accumulating evidences indicate that non-coding RNAs (ncRNAs) including long (lncRNAs) and microRNAs (miRNAs) acting as crucial regulators in osteosarcoma (OS). Previously, we reported Rho associated coiled-coil containing protein kinase 1 (ROCK1), a metastatic-related gene was negatively regulated by microRNA-335-5p (miR-335-5p) work an oncogene osteosarcoma. Whether any participate the upstream of miR-335-5p/ROCK1 axial remains unclear. Expression differentiation antagonizing non-protein...
Metastasis is a complex biological process that has been difficult to delineate in human colorectal cancer (CRC) patients. A major obstacle understanding metastatic lineages the extensive intra-tumor heterogeneity at primary and tumor sites. To address this problem, we developed highly multiplexed single-cell DNA sequencing approach trace of two CRC patients with matched liver metastases. Single-cell copy number or mutational profiling was performed, addition bulk exome targeted...
Long non-coding RNAs (lncRNAs) are involved in various biological processes and diseases including osteosarcoma. RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is overly expressed But the function mechanism it works on osteosarcoma proliferation metastasis mediated by Rho associated coiled-coil containing protein kinase (ROCK1) 2 (ROCK2) remain unclear. In present study, an elevated MALAT1 was found tissues cell lines, correlated with a poor prognosis patients. The...
Long non‐coding RNA (lnc ) have been the focus of increasing attention due to role they play in many diseases, including osteosarcoma. The function taurine upregulated gene 1 ( TUG 1) and its mechanism osteosarcoma remain unclear. In our research, we found that was elevated correlated with a poor prognosis patients. addition, following functional experiment showed decreased could remarkably inhibit cell migration invasion, indicating functioned as an oncogene Moreover, revealed...
The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recently shown to be dysregulated in several cancers. However, the mechanisms underlying role of MALAT1 breast cancer remain unclear. Herein, we showed that was aberrantly increased tissues and cells. MALAT1-siRNA inhibited cell proliferation cycle progression vitro vivo. Furthermore, acted as an endogenous potent regulator by directly binding miR-124 down-regulating expression. In...
Long non-coding RNAs (lncRNAs) play key roles in various malignant tumors, including colorectal cancer (CRC). RNA differentiation antagonizing non-protein coding (DANCR) is overexpressed CRC patients, but whether it affects proliferation and metastasis via regulation of heat shock protein 27 (HSP27) remains unclear. In the present study, we found that DANCR was highly expressed correlated with CRC. addition, demonstrated HSP27 were both targets microRNA-577 (miR-577) shared same binding...
Abstract Long non-coding RNA (lncRNA) SNHG14 is previously found to be overexpressed in several types of cancers. However, the clinical significance and biological function non-small cell lung cancer (NSCLC) are still elusive. In present study, we that was aberrantly up-regulated NSCLC tissues from patients lines compared with their normal counterparts. Increased expression closely associated aggressive tumor progression poor outcome patients. Knockdown inhibited proliferation through...
Osteoarthritis (OA) is a common and troublesome disease among the elderly, characterized by extracellular matrix (ECM) degradation. The function of long non‑coding RNA X‑inactive‑specific transcript (XIST) its working mechanism in ECM degradation remains unclear. In present study, XIST was revealed to be upregulated OA specimens articular chondrocytes (ACs) derived from tissue (AC/OA) interleukin‑1β (IL‑1β)‑treated ACs. Loss‑of‑function experiments demonstrated that downregulation suppressed...
Neutrophil extracellular traps (NETs) are closely related to cancer progression. NETs-related lncRNAs play crucial roles in non-small-cell lung (NSCLC) but there have been no systematic studies regarding long noncoding RNA (lncRNA) signatures forecast the prognosis of NSCLC patients. It's essential build commensurate lncRNA signatures. The expression profiles prognostic mRNAs and relevant clinical data patients were downloaded from Cancer Genome Atlas (TCGA) database. genes came results our...
Abstract Colorectal cancer (CRC) is one of the most common cancers around world and endangers human health seriously. Liver metastasis an important factor affecting long-term prognosis CRC specific mechanism CRLM (colorectal with liver metastasis) not fully understood. LZTS1 has been found dysregulated in many cancers, especially CRC. Theories suggested that hypermethylation promoter regions was responsible for abnormal expression multiple malignant tumors. Although role cell proliferation...
MicroRNAs are small non-coding RNAs that play important roles in vascular smooth muscle cell (VSMC) function. This study investigated the role of miR-379 on proliferation, invasion, and migration VSMCs explored underlying mechanisms thereof.MicroRNA, mRNA, protein levels were determined by quantitative real-time PCR western blot. The proliferative, invasive, migratory abilities measured CCK-8, wound healing assay, respectively. Luciferase reporter assay was used to confirm target...
Long noncoding RNAs (lncRNAs) are involved in numerous physiological functions. However, their mechanisms acute myocardial infarction (AMI) not well understood.We performed an RNA-seq analysis to explore the molecular mechanism of AMI by constructing a lncRNA-miRNA-mRNA axis based on ceRNA hypothesis. The target microRNA data were used design global triple network. Thereafter, functional enrichment and clustering topological analyses conducted using expression lncRNA SNHG8, SOCS3 ICAM1 was...
Background: Metastatic disease caused by prostate cancer (PCa) is the principal cause of PCa-related mortality. Long non-protein-coding RNAs may possess significant cellular functions. Plasmacytoma variant translocation 1 (PVT1), a long non-coding RNA encoded human PVT1 gene, an oncogene, which can regulate several tumor-related genes. In PCa, function and mechanism are unclear. NOP2 being pursued as prognostic marker for aggressiveness, promotes mouse fibroblast growth tumor formation....
Abstract A high-sensitivity inspection method for ultra-low-density defects in the thin films is presented by performing spatial correlation calculations on X-ray dark-field scattering. The sensitivity of defect theoretically analyzed under varying exposure times and thicknesses. simulation results demonstrate a 25 increase compared to scanning scattering contrast microscopy (SSCM). An experiment was performed at Shanghai Synchrotron Radiation Facility 56 nm particle successfully inspected...
Long noncoding RNAs (lncRNAs) are associated with various diseases including cataracts. The role of lncRNA potassium voltage‑gated channel subfamily Q member 1 opposite strand/antisense transcript (KCNQ1OT1) on lens epithelial cell (LEC) proliferation and epithelial‑mesenchymal transition (EMT) in cataracts disease remains unclear. In the present study, KCNQ1OT1 mothers against decapentaplegic homolog (SMAD)4 expression levels were upregulated human cataract posterior capsular samples...
// Cheng Xiang 1 , Mao-lin Zhang Qun-zi Zhao Qiu-ping Xie Hai-chao Yan Xing Yu Ping Wang Yong Department of Thyroid Surgery, Second Affiliated Hospital Medical College, Zhejiang University, Hangzhou, Province, China Correspondence to: Wang, email: surgwy@yeah.net Keywords: thyroid cancer, lncRNA, 131 I, PARP-1, SLC6A9-5:2 Received: September 16, 2016 Accepted: December 28, Published: January 10, 2017 ABSTRACT Recent studies have indicated that long non-coding RNAs play crucial roles in...