A5100379410- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Microplastics and Plastic Pollution
- Antimicrobial agents and applications
- Circular RNAs in diseases
- RNA modifications and cancer
- Marine Biology and Environmental Chemistry
- Glioma Diagnosis and Treatment
- Tea Polyphenols and Effects
- Neonatal and fetal brain pathology
- Optical Imaging and Spectroscopy Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Natural product bioactivities and synthesis
- Brain Tumor Detection and Classification
- RNA Research and Splicing
- Ginseng Biological Effects and Applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Tannin, Tannase and Anticancer Activities
- MicroRNA in disease regulation
- Cancer-related gene regulation
- TGF-β signaling in diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Phytochemical Studies and Bioactivities
- bioluminescence and chemiluminescence research
Guangdong University of Foreign Studies
2024-2025
Sun Yat-sen University
2021-2024
PLA 306 Hospital
2013-2022
Shandong Normal University
2020
Beijing University of Chinese Medicine
2019
Guang’anmen Hospital
2019
Fuyang City People's Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Hanzhong People's Hospital
2018
Xian Central Hospital
2018
Experimental data suggest that mitochondria is involved in tumorigenesis. However, little known about the qualitative and quantitative changes of mtDNA colorectal cancer tissues. We therefore conducted possible correlations mitochondrial DNA (mtDNA) copy number (CRC) with clinical pathological findings CRC prognosis.mtDNA numbers tissue adjacent non-cancerous samples were measured using real-time polymerase chain reaction analyses from 60 patients admitted to our hospital. examined...
Abstract Long non-coding RNA (lncRNA) SNHG14 is previously found to be overexpressed in several types of cancers. However, the clinical significance and biological function non-small cell lung cancer (NSCLC) are still elusive. In present study, we that was aberrantly up-regulated NSCLC tissues from patients lines compared with their normal counterparts. Increased expression closely associated aggressive tumor progression poor outcome patients. Knockdown inhibited proliferation through...
The long noncoding RNA (LncRNA) SNHG7 (small nuclear host gene 7) is a novel LncRNA and functions as an oncogene to promote tumor proliferation inhibits apoptosis in many cancers. However, the role of osteosarcoma (OS) remains be further investigated. In this study, OS tissues corresponding relative normal (n = 30) were collected determine expression OS. results indicated that high level correlated with Enneking stage, distant metastasis, short overall survival time patients. Moreover,...
Human dihydroorotate dehydrogenase (hDHODH) is an attractive tumor target essential to de novo pyrimidine biosynthesis. Novel potent hDHODH inhibitors with low toxicity are urgently needed. Herein, we demonstrate the isolation of 25 ascochlorin (ASC) derivatives, including 13 new ones, from coral-derived fungus Acremonium sclerotigenum, and several them showed pronounced inhibitions against triple-negative breast cancer (TNBC) cell lines, MDA-MB-231/-468. Interestingly, found that required...
Osteosarcoma (OS) is the most common malignant bone tumor with a poor prognosis. Here, we show that nuclear receptor RORγ may serve as potential therapeutic target in OS. OS exhibits hyperactivated oxidative phosphorylation (OXPHOS) program, which fuels carbon source to promote progression. We found overexpressed tumors and linked OXPHOS. induces expression of PGC-1β physically interacts it activate OXPHOS program by upregulating respiratory chain component genes. Inhibition strongly...
Brain age gap, the difference between estimated brain and chronological via magnetic resonance imaging, has emerged as a pivotal biomarker in detection of abnormalities. While deep learning is accurate estimating age, absence uncertainty estimation may pose risks clinical use. Moreover, current 3D models are intricate, using 2D slices hinders comprehensive dimensional data integration. Here, we introduced Spectral-normalized Neural Gaussian Process (SNGP) accompanied by 2.5D slice approach...
Brain age gap, the difference between estimated brain and chronological via magnetic resonance imaging, has emerged as a pivotal biomarker in detection of abnormalities. While deep learning is accurate estimating age, absence uncertainty estimation may pose risks clinical use. Moreover, current 3D models are intricate, using 2D slices hinders comprehensive dimensional data integration. Here, we introduced Spectral-normalized Neural Gaussian Process (SNGP) accompanied by 2.5D slice approach...
Pseudogenes are pivotal funtional non-coding RNAs in tumorigenesis. Cumulative evidences have shown that pituitary tumor-transforming 3, pseudogene (PTTG3P), serves as an oncogene multiple human cancers. However, its expression pattern, biological function, and potential targets esophageal squamous cell carcinoma (ESCC) remain unknown. Here, by quantitative real-time polymerase chain reaction (qRT-PCR) 50 cases of ESCC, we found the PTTG3P, PTTG1 PTTG2 cancer tissues lines were significantly...
Due to the high mortality and rapid disease progression, ovarian cancer remains one of most common malignancies threatening health women. The present study was conducted explore anticancer effects underlying mechanisms poricoic acid A (PAA), main components Poria cocos, on cancer. We investigated different concentrations PAA in SKOV3 cell line. Cell viability proliferation were examined by CCK-8 assay. Cellular migration invasion assessed scratch Transwell assays, respectively. effect PPA...
Abstract Background: P-cadherin is a calcium-dependent cell–cell adhesion glycoprotein. It has been implicated in invasiveness and metastasis. However, the clinical prognostic value of overexpression patients with breast cancer (BC) remains unsettled. Methods: A systematic literature search will be performed all available databases to quantitatively review eligible studies identify relevant data, which could used detect relationship between overall survival (OS), disease-free (DFS),...
To investigate the therapeutic effect of rabeprazole and rebamipide on patient age over 60 with dual antiplatelet therapy (DAPT)–related upper gastrointestinal hemorrhage following percutaneous coronary intervention (PCI). A total 360 patients undergoing PCI were recruited for involving a combined treatment aspirin (100 mg/d) clopidogrel (75 mg/d). The enrolled divided into 4 groups: control group, + group. incidence severity any major adverse cardiac events (MACEs) observed 6 months after...
Objective To develop a simple,sensitive,and accurate method for the determination of shionone in rat plasma after administration shionone.Methods The separation was developed by HPLC on Waters shieldTM RP18 column (150mm × 3.9mm,5 μm) with mobile phase composed acetonitrile-0.05％ phosphoric acid water (98:2) at flow rate 1.0 mL/min.UV Detector set 200nm.Results linear range standard curves 0.043-1.720 μg/ml correlation coefficient 0.995.The intra-and inter-day precisions were all below...