A5100381062- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Nerve injury and regeneration
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Signaling Pathways in Disease
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Mast cells and histamine
- Hip disorders and treatments
- Spinal Fractures and Fixation Techniques
- Orthopaedic implants and arthroplasty
- Proteoglycans and glycosaminoglycans research
- Cytokine Signaling Pathways and Interactions
Northwest University
2025
Dalian Medical University
2015-2024
First Affiliated Hospital of Dalian Medical University
2015-2024
Shanghai University of Medicine and Health Sciences
2023
Jiading District Central Hospital
2023
Duke Medical Center
2000-2021
Duke University Hospital
2000-2021
Zhengzhou University
2021
Huazhong University of Science and Technology
2021
Central Hospital of Wuhan
2021
CTLA-4, a negative regulator of T cell function, was found to associate with the receptor (TCR) complex ζ chain in primary cells. The association TCRζ reconstituted 293 transfectants, enhanced by p56 lck -induced tyrosine phosphorylation. Coexpression CTLA-4–associated phosphatase, SHP-2, resulted dephosphorylation bound CTLA-4 and abolished -inducible TCRζ–CTLA-4 interaction. Thus, inhibits TCR signal transduction binding inhibiting phosphorylation after activation. These findings have...
T-cell antigen receptor (TCR) engagement activates multiple protein tyrosine kinases (PTKs), including the Src family member, Lck, and Syk-related PTK, ZAP-70.Studies in ZAP-70-deficient humans have demonstrated that ZAP-70 plays crucial roles activation development.However, progress toward a detailed understanding of regulation function during TCR signaling has been hampered by lack suitable model for biochemical genetic analyses.In this report, we describe isolation phenotypic...
Long non-coding RNAs (lncRNAs) are involved in various biological processes and diseases including osteosarcoma. RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is overly expressed But the function mechanism it works on osteosarcoma proliferation metastasis mediated by Rho associated coiled-coil containing protein kinase (ROCK1) 2 (ROCK2) remain unclear. In present study, an elevated MALAT1 was found tissues cell lines, correlated with a poor prognosis patients. The...
Long non‐coding RNA (lnc ) have been the focus of increasing attention due to role they play in many diseases, including osteosarcoma. The function taurine upregulated gene 1 ( TUG 1) and its mechanism osteosarcoma remain unclear. In our research, we found that was elevated correlated with a poor prognosis patients. addition, following functional experiment showed decreased could remarkably inhibit cell migration invasion, indicating functioned as an oncogene Moreover, revealed...
Mechanical cues exert considerable influence on the fates of stem cells and terminally differentiated chondrocytes. The elucidation interactions between cell fate mechanical in nuclear mechanotransduction will provide new clues to modulate tissue homeostasis regeneration. In this study, we used an integrated microfluidic perfusion device simultaneously generate multiple-parameter fluid shear stresses investigate role flow stimuli regulation Yes-associated protein (YAP) expression mesenchymal...
In the past decade, mesenchymal stem cells (MSCs) have been widely used for treatment of osteoarthritis (OA), and extracellular vesicles (EVs) may play a major role in efficacy this treatment. Hypoxia can change cargo biological functions MSC-derived EVs (MSC-EVs). The aim present study was to determine whether effects hypoxia-preconditioned MSC-EVs on OA cartilage repair are superior normoxia-preconditioned MSC-EVs. By using vitro vivo models, we verified that improved chondrocyte...
Human osteosarcoma usually presented a high tendency to metastatic spread and caused poor outcomes, however, the underlying mechanism was still largely unknown. In present study, using series of in vitro experiments an animal model, we investigated roles HOX antisense intergenic RNA (HOTAIR) during proliferation invasion osteosarcoma. According with our results, HOTAIR commonly overexpressed osteosarcoma, which significantly correlated advanced tumor stage, highly histological grade...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Mar 2003Maspin Functions as Tumor Suppressor by Increasing Cell Adhesion to Extracellular Matrix in Prostate Cells SHAJI ABRAHAM, WEIGUO ZHANG, NORMAN GREENBERG, and MING ZHANG ABRAHAMSHAJI ABRAHAM , ZHANGWEIGUO GREENBERGNORMAN GREENBERG ZHANGMING View All Author Informationhttps://doi.org/10.1097/01.ju.0000040245.70349.37AboutFull TextPDF ToolsAdd favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked...
Currently, Posterior Short Segment Pedicle Screw Fixation is a popular procedure for treating unstable thoracolumbar/lumbar burst fracture. But progressive kyphosis and high rate of hardware failure because lack the anterior column support remains concern. The efficacy different methods debatable each technique has its advantages disadvantages. A consecutive series 20 patients with isolated fractures were treated by posterior short segment pedicle screw fixation transforaminal interbody...
In native fibrocartilage, mechanotransduction allows the cells to perceive physical microenvironment not only through topographical cues from extracellular matrix, but also mechanical cues, such as interstitial flow. To create a that simultaneously integrates nanotopography and flow stimulus, we developed biomimetic microfluidic device embedded with aligned nanofibers contain microchambers of different angles, which enabled direction form angles fibers. Using this device, investigated...
Breast cancer is the most commonly diagnosed among females, and chemoresistance constitutes a major clinical obstacle to treatment of this disease. MicroRNAs (miRNAs) are related human development, progression drug resistance. To identify breast chemoresistance-associated miRNAs, miRNA microarray dataset GSE71142, including five chemoresistant tissues chemosensitive tissues, was downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed miRNAs (DE-miRNAs) were obtained...
Cross-linking of the FcεRI activates phosphatidyl inositol 3 kinase (PI3K) and mitogen-activated protein pathways. Previous studies demonstrate that Ras guanyl nucleotide-releasing (RasGRP)1 is essential in T cell receptor–mediated Ras-Erk activation. Here, we report RasGRP1 plays an important role FcεRI-mediated PI3K activation mast function. RasGRP1-deficient mice failed to mount anaphylactic allergic reactions. RasGRP1−/− cells had markedly reduced degranulation cytokine production....
Coordinated gene transcription in plastid and nucleus is essential for the photosynthetic apparatus assembly during chloroplast biogenesis. Despite identification of several factors regulating nuclear-encoded genes,no factor has been discovered. Here we report that BAI1 ("albino" Chinese), a nucleus-plastid dual-targeted C2H2-type zinc finger Arabidopsis, positively regulates orchestrates nuclear genes. The knockout leads to blockage formation, albino seedling, lethality. In plastid, newly...